Neonatal castration affects intrathymic kinetics of T-cell differentiation and the spleen T-cell level

To test putative interdependence in the ontogenesis of the hypothalamic–pituitary–gonadal and thymic–lymphatic axes, thymocyte differentiation and maturation was examined in neonatally castrated (Cx) adult rats. In the hypercellular thymi of Cx rats, the proportion of the least mature CD4−CD8−TCRαβ−...

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