Efficient production of canine interferon-alpha in silkworm Bombyx mori by use of a BmNPV/Bac-to-Bac expression system

We exploited the silkworm Bombyx mori for the production of recombinant canine interferon-alpha (CaIFN-α). The recombinant baculovirus harboring canine interferon gene was rapidly generated by the BmNPV/Bac-to-Bac system that was recently developed. In B. mori-derived cell lines, the expression of t...

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Veröffentlicht in:	Applied microbiology and biotechnology 2008-02, Vol.78 (2), p.221-226
Hauptverfasser:	Na, Zhao, Huipeng, Yao, Lipan, Lan, Cuiping, Cao, Umashankar, M. L, Xingmeng, Lu, Xiaofeng, Wu, Bing, Wang, Weizheng, Cui, Cenis, J. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Amino acids Animals Antineoplastic drugs. Cytokines Baculoviridae - genetics Baculovirus Biological and medical sciences Biotechnological Products and Process Engineering Biotechnology BmNPV/Bac-to-Bac expression system Bombyx - genetics Bombyx - metabolism Bombyx mori Bombyx mori NPV Canine interferon-α Cell Line Cell Survival Chromatography, Affinity Cloning Dogs Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Gene expression Genetic engineering Genetic Vectors Genomes Glycosylation Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Infections Infectious diseases Interferon Interferon-alpha - biosynthesis Interferon-alpha - genetics Interferon-alpha - isolation & purification Larva - genetics Larva - metabolism Larvae Life Sciences Microbial Genetics and Genomics Microbiology Molecular Sequence Data Pathogens Peptides Production of active biomolecules Proteins Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - isolation & purification Rhabdoviridae Infections - immunology Sequence Analysis, DNA silkworms Studies Vesicular stomatitis virus Vesiculovirus - immunology Viral infections Viruses
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