The Myeloid Differentiation Factor 88 (MyD88) Is Required for CD4+ T Cell Effector Function in a Murine Model of Inflammatory Bowel Disease

Abnormal T cell responses to commensal bacteria are involved in the pathogenesis of inflammatory bowel disease. MyD88 is an essential signal transducer for TLRs in response to the microflora. We hypothesized that TLR signaling via MyD88 was important for effector T cell responses in the intestine. T...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-02, Vol.180 (3), p.1886-1894
Hauptverfasser:	Fukata, Masayuki, Breglio, Keith, Chen, Anli, Vamadevan, Arunan S, Goo, Tyralee, Hsu, David, Conduah, Daisy, Xu, Ruliang, Abreu, Maria T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - transplantation Homeodomain Proteins - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Interleukin-17 - metabolism Interleukin-23 - metabolism Interleukin-6 - metabolism Leukocyte Common Antigens - analysis Lymphocyte Activation Mice Mice, Mutant Strains Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - immunology Phosphorylation Receptors, Antigen, T-Cell - metabolism STAT3 Transcription Factor - metabolism T-Lymphocytes, Helper-Inducer - immunology
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