Therapeutic Potential of Atrial Natriuretic Peptide Administration on Peripheral Arterial Diseases

Peripheral arterial diseases are caused by arterial sclerosis and impaired collateral vessel formation, which are exacerbated by diabetes, often leading to leg amputation. We have reported that an activation of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway accelerated vascular...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2008-02, Vol.149 (2), p.483-491
Hauptverfasser:	Park, Kwijun, Itoh, Hiroshi, Yamahara, Kenichi, Sone, Masakatsu, Miyashita, Kazutoshi, Oyamada, Naofumi, Sawada, Naoya, Taura, Daisuke, Inuzuka, Megumi, Sonoyama, Takuhiro, Tsujimoto, Hirokazu, Fukunaga, Yasutomo, Tamura, Naohisa, Nakao, Kazuwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amputation Animals Ankle Arteriosclerosis Obliterans - drug therapy Arteriosclerosis Obliterans - physiopathology Atrial Natriuretic Factor - administration & dosage Atrial natriuretic peptide Biological and medical sciences Blood and lymphatic vessels Blood flow Blood pressure Blood Pressure - drug effects Capillary flow Cardiology. Vascular system Cardiovascular diseases Cyclic GMP Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetic Angiopathies - drug therapy Diabetic Angiopathies - physiopathology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Foot Ulcer - drug therapy Foot Ulcer - physiopathology Fundamental and applied biological sciences. Psychology Gangrene - drug therapy Gangrene - physiopathology Humans Hyperglycemia Infusions, Intravenous Ischemia Kinases Leg Male Medical sciences Mice Mice, Inbred C57BL Middle Aged Neovascularization, Physiologic - drug effects Peptides Peripheral Vascular Diseases - drug therapy Peripheral Vascular Diseases - physiopathology Protein kinase G Recovery Regional Blood Flow - drug effects Sclerosis Streptozocin Thromboangiitis Obliterans - drug therapy Thromboangiitis Obliterans - physiopathology Treatment Outcome Ulcers Vertebrates: endocrinology
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