Recombinant human antithrombin expressed in Chinese hamster ovary cells shows in vivo efficacy on rat DIC model similarly to plasma-derived antithrombin regardless of different N -glycosylation

Abstract Plasma-derived human antithrombin (pAT) is used for the treatments of disseminated intravascular coagulation (DIC) and hereditary antithrombin deficiencies. We expressed recombinant human antithrombin (rAT) in Chinese hamster ovary (CHO) cells. The purified rAT is composed of 55% α-isoform...

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Veröffentlicht in:	Thrombosis research 2007-01, Vol.119 (5), p.631-641
Hauptverfasser:	Hirose, Masaaki, Tsukada, Minoru, Hirayama, Fumihiro, Kubo, Yoshiji, Kajii, Masahiko, Mochizuki, Shinobu, Hamato, Nobuaki, Ohi, Hideyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - drug effects Alanine Transaminase - metabolism Animals Antithrombin Antithrombin III Deficiency - drug therapy Antithrombin III Deficiency - metabolism Antithrombins - biosynthesis Antithrombins - chemistry Antithrombins - therapeutic use Aspartate Aminotransferases - drug effects Aspartate Aminotransferases - metabolism Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cardiovascular system CHO Cells Cricetinae Cricetulus DIC Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Disseminated Intravascular Coagulation - drug therapy Disseminated Intravascular Coagulation - metabolism Fibrinogen - drug effects Fundamental and applied biological sciences. Psychology Glycosylation Hematology, Oncology and Palliative Medicine Humans Lipopolysaccharides - pharmacology Male Medical sciences N-Glycosylation Oligosaccharides - chemistry Oligosaccharides - metabolism Pharmacology. Drug treatments Protein Isoforms - biosynthesis Protein Isoforms - chemistry Protein Isoforms - therapeutic use Rats Rats, Wistar Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - therapeutic use Stereoisomerism Thromboplastin - pharmacology Time Factors Vascular wall Vertebrates: cardiovascular system β-Isoform
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