Interpreting Properties of Microbicide Drug Delivery Gels:Analyzing Deployment Kinetics due to Squeezing

Prophylactic efficacy of topical microbicidal drug delivery formulations against HIV may depend upon their abilities to coat and be retained on epithelial surfaces where infection begins. Rheological and surface properties play paramount roles in governing coating. While fundamental fluid mechanical...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2007-04, Vol.96 (4), p.835-850
Hauptverfasser:	Kieweg, Sarah L., Katz, David F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - administration & dosage Anti-Infective Agents, Local - administration & dosage Biological and medical sciences Body Temperature Carrageenan - administration & dosage Cellulose - administration & dosage Drug Delivery Systems formulation vehicle Gels General pharmacology HIV Kinetics mathematical model Medical sciences microbicide nonNewtonian Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments physicochemical properties polymeric drug delivery systems Polyvinyls - administration & dosage squeezing flows Viscosity
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