Inhibition errors in borderline personality disorder with psychotic-like symptoms
The aim of this study was to examine whether patients with borderline personality disorder (BPD) have deficits in cognitive inhibition as measured with an anti-saccade eye task similar to patients with schizophrenia (Sz). Furthermore, we investigated whether these inhibition errors were more promine...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2008, Vol.32 (1), p.267-273 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Grootens, Koen P. van Luijtelaar, Gilles Buitelaar, Jan K. van der Laan, Annemieke Hummelen, Jacobus W. Verkes, Robbert J. |
| description | The aim of this study was to examine whether patients with borderline personality disorder (BPD) have deficits in cognitive inhibition as measured with an anti-saccade eye task similar to patients with schizophrenia (Sz). Furthermore, we investigated whether these inhibition errors were more prominent among BPD patients with psychotic-like symptoms than among BPD patients without these symptoms.
An anti-saccade task was administered in 32 BPD patients (among them, 20 had with psychotic-like symptoms), 21 patients with recent onset schizophrenia (Sz), and 25 healthy controls (HC). The percentage inhibition errors in the anti-saccade task were the primary outcome variable, in addition, the percentage of anticipatory errors was measured.
Sz patients showed more inhibition errors than HC and BPD (
p
<
.001 and
p
<
.05 resp.), whereas BPD patients scored in between Sz and HC. The difference with HC was significant as well (
p
<
.05). BPD patients with psychotic-like symptoms showed more inhibition errors than BPD patients without these symptoms (
p
<
.05). BPD patients showed more anticipatory errors than HC (
p
<
.001), whereas Sz patients did not (
p
<
.26).
The data demonstrate that inhibition deficits, as measured with anti-saccadic eye movement task, may be characteristic among BPD patients and in a larger extent in patients with psychotic-like symptoms. This inhibition deficit was distinct from a general predisposition to response impulsively as measured by anticipatory errors, which was found in the whole group of BPD patients. Psychotic-like symptoms may be an important target dimension for future BPD research and treatment. |
| doi_str_mv | 10.1016/j.pnpbp.2007.08.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70229957</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S027858460700303X</els_id><sourcerecordid>19513661</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-20256b43644c99e3652f5d0a3bc8fb7c7c3a5ac9db1c92cbaf7f44dc4a44cfe3</originalsourceid><addsrcrecordid>eNqFkE1r3DAQhkVoaTZpf0Gg-NLe7OrLsnTooYS2CQRCIXchjcestrblSt6G_fdRskt7a08zMM_7MjyEXDHaMMrUp12zzItfGk5p11DdUE7PyIbpTteSM_WKbCgve6ulOicXOe8opUxQ8Yacs05rI5nZkB-38zb4sIY4V5hSTLkKc-Vj6jGNYcZqwZTj7MawHqo-5JdD9RjWbbXkA2zjGqAew0-s8mFa1jjlt-T14MaM707zkjx8-_pwfVPf3X-_vf5yV4Nkeq055a3yUigpwRgUquVD21MnPOjBd9CBcK0D03sGhoN3QzdI2YN0JTCguCQfj7VLir_2mFc7hQw4jm7GuM-2o5wb03b_BZlpmVCKFVAcQUgx54SDXVKYXDpYRu2zcbuzL8bts3FLtS3GS-r9qX7vJ-z_Zk6KC_DhBLgMbhySmyHkP1zpUlpwUbjPRw6LtN8Bk80QcAbsQ0JYbR_DPx95AqapojE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19513661</pqid></control><display><type>article</type><title>Inhibition errors in borderline personality disorder with psychotic-like symptoms</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Grootens, Koen P. ; van Luijtelaar, Gilles ; Buitelaar, Jan K. ; van der Laan, Annemieke ; Hummelen, Jacobus W. ; Verkes, Robbert J.</creator><creatorcontrib>Grootens, Koen P. ; van Luijtelaar, Gilles ; Buitelaar, Jan K. ; van der Laan, Annemieke ; Hummelen, Jacobus W. ; Verkes, Robbert J.</creatorcontrib><description><![CDATA[The aim of this study was to examine whether patients with borderline personality disorder (BPD) have deficits in cognitive inhibition as measured with an anti-saccade eye task similar to patients with schizophrenia (Sz). Furthermore, we investigated whether these inhibition errors were more prominent among BPD patients with psychotic-like symptoms than among BPD patients without these symptoms.
An anti-saccade task was administered in 32 BPD patients (among them, 20 had with psychotic-like symptoms), 21 patients with recent onset schizophrenia (Sz), and 25 healthy controls (HC). The percentage inhibition errors in the anti-saccade task were the primary outcome variable, in addition, the percentage of anticipatory errors was measured.
Sz patients showed more inhibition errors than HC and BPD (
p
<
.001 and
p
<
.05 resp.), whereas BPD patients scored in between Sz and HC. The difference with HC was significant as well (
p
<
.05). BPD patients with psychotic-like symptoms showed more inhibition errors than BPD patients without these symptoms (
p
<
.05). BPD patients showed more anticipatory errors than HC (
p
<
.001), whereas Sz patients did not (
p
<
.26).
The data demonstrate that inhibition deficits, as measured with anti-saccadic eye movement task, may be characteristic among BPD patients and in a larger extent in patients with psychotic-like symptoms. This inhibition deficit was distinct from a general predisposition to response impulsively as measured by anticipatory errors, which was found in the whole group of BPD patients. Psychotic-like symptoms may be an important target dimension for future BPD research and treatment.]]></description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2007.08.020</identifier><identifier>PMID: 17889419</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; Biological and medical sciences ; Borderline personality disorder ; Borderline Personality Disorder - complications ; Electrooculography - methods ; Eye Movements - physiology ; Female ; Humans ; Impulsivity ; Inhibition ; Inhibition (Psychology) ; Male ; Medical sciences ; Neuropharmacology ; Neuropsychological Tests ; Personality disorders ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychometrics ; Psychopathology. Psychiatry ; Psychoses ; Psychosis ; Psychotic Disorders - economics ; Saccades ; Schizophrenia ; Schizophrenia - physiopathology</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2008, Vol.32 (1), p.267-273</ispartof><rights>2007 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-20256b43644c99e3652f5d0a3bc8fb7c7c3a5ac9db1c92cbaf7f44dc4a44cfe3</citedby><cites>FETCH-LOGICAL-c418t-20256b43644c99e3652f5d0a3bc8fb7c7c3a5ac9db1c92cbaf7f44dc4a44cfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S027858460700303X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20068323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17889419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grootens, Koen P.</creatorcontrib><creatorcontrib>van Luijtelaar, Gilles</creatorcontrib><creatorcontrib>Buitelaar, Jan K.</creatorcontrib><creatorcontrib>van der Laan, Annemieke</creatorcontrib><creatorcontrib>Hummelen, Jacobus W.</creatorcontrib><creatorcontrib>Verkes, Robbert J.</creatorcontrib><title>Inhibition errors in borderline personality disorder with psychotic-like symptoms</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description><![CDATA[The aim of this study was to examine whether patients with borderline personality disorder (BPD) have deficits in cognitive inhibition as measured with an anti-saccade eye task similar to patients with schizophrenia (Sz). Furthermore, we investigated whether these inhibition errors were more prominent among BPD patients with psychotic-like symptoms than among BPD patients without these symptoms.
An anti-saccade task was administered in 32 BPD patients (among them, 20 had with psychotic-like symptoms), 21 patients with recent onset schizophrenia (Sz), and 25 healthy controls (HC). The percentage inhibition errors in the anti-saccade task were the primary outcome variable, in addition, the percentage of anticipatory errors was measured.
Sz patients showed more inhibition errors than HC and BPD (
p
<
.001 and
p
<
.05 resp.), whereas BPD patients scored in between Sz and HC. The difference with HC was significant as well (
p
<
.05). BPD patients with psychotic-like symptoms showed more inhibition errors than BPD patients without these symptoms (
p
<
.05). BPD patients showed more anticipatory errors than HC (
p
<
.001), whereas Sz patients did not (
p
<
.26).
The data demonstrate that inhibition deficits, as measured with anti-saccadic eye movement task, may be characteristic among BPD patients and in a larger extent in patients with psychotic-like symptoms. This inhibition deficit was distinct from a general predisposition to response impulsively as measured by anticipatory errors, which was found in the whole group of BPD patients. Psychotic-like symptoms may be an important target dimension for future BPD research and treatment.]]></description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Borderline personality disorder</subject><subject>Borderline Personality Disorder - complications</subject><subject>Electrooculography - methods</subject><subject>Eye Movements - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Impulsivity</subject><subject>Inhibition</subject><subject>Inhibition (Psychology)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neuropsychological Tests</subject><subject>Personality disorders</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychometrics</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychosis</subject><subject>Psychotic Disorders - economics</subject><subject>Saccades</subject><subject>Schizophrenia</subject><subject>Schizophrenia - physiopathology</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVoaTZpf0Gg-NLe7OrLsnTooYS2CQRCIXchjcestrblSt6G_fdRskt7a08zMM_7MjyEXDHaMMrUp12zzItfGk5p11DdUE7PyIbpTteSM_WKbCgve6ulOicXOe8opUxQ8Yacs05rI5nZkB-38zb4sIY4V5hSTLkKc-Vj6jGNYcZqwZTj7MawHqo-5JdD9RjWbbXkA2zjGqAew0-s8mFa1jjlt-T14MaM707zkjx8-_pwfVPf3X-_vf5yV4Nkeq055a3yUigpwRgUquVD21MnPOjBd9CBcK0D03sGhoN3QzdI2YN0JTCguCQfj7VLir_2mFc7hQw4jm7GuM-2o5wb03b_BZlpmVCKFVAcQUgx54SDXVKYXDpYRu2zcbuzL8bts3FLtS3GS-r9qX7vJ-z_Zk6KC_DhBLgMbhySmyHkP1zpUlpwUbjPRw6LtN8Bk80QcAbsQ0JYbR_DPx95AqapojE</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Grootens, Koen P.</creator><creator>van Luijtelaar, Gilles</creator><creator>Buitelaar, Jan K.</creator><creator>van der Laan, Annemieke</creator><creator>Hummelen, Jacobus W.</creator><creator>Verkes, Robbert J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Inhibition errors in borderline personality disorder with psychotic-like symptoms</title><author>Grootens, Koen P. ; van Luijtelaar, Gilles ; Buitelaar, Jan K. ; van der Laan, Annemieke ; Hummelen, Jacobus W. ; Verkes, Robbert J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-20256b43644c99e3652f5d0a3bc8fb7c7c3a5ac9db1c92cbaf7f44dc4a44cfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Borderline personality disorder</topic><topic>Borderline Personality Disorder - complications</topic><topic>Electrooculography - methods</topic><topic>Eye Movements - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Impulsivity</topic><topic>Inhibition</topic><topic>Inhibition (Psychology)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neuropsychological Tests</topic><topic>Personality disorders</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychometrics</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychosis</topic><topic>Psychotic Disorders - economics</topic><topic>Saccades</topic><topic>Schizophrenia</topic><topic>Schizophrenia - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grootens, Koen P.</creatorcontrib><creatorcontrib>van Luijtelaar, Gilles</creatorcontrib><creatorcontrib>Buitelaar, Jan K.</creatorcontrib><creatorcontrib>van der Laan, Annemieke</creatorcontrib><creatorcontrib>Hummelen, Jacobus W.</creatorcontrib><creatorcontrib>Verkes, Robbert J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grootens, Koen P.</au><au>van Luijtelaar, Gilles</au><au>Buitelaar, Jan K.</au><au>van der Laan, Annemieke</au><au>Hummelen, Jacobus W.</au><au>Verkes, Robbert J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition errors in borderline personality disorder with psychotic-like symptoms</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2008</date><risdate>2008</risdate><volume>32</volume><issue>1</issue><spage>267</spage><epage>273</epage><pages>267-273</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract><![CDATA[The aim of this study was to examine whether patients with borderline personality disorder (BPD) have deficits in cognitive inhibition as measured with an anti-saccade eye task similar to patients with schizophrenia (Sz). Furthermore, we investigated whether these inhibition errors were more prominent among BPD patients with psychotic-like symptoms than among BPD patients without these symptoms.
An anti-saccade task was administered in 32 BPD patients (among them, 20 had with psychotic-like symptoms), 21 patients with recent onset schizophrenia (Sz), and 25 healthy controls (HC). The percentage inhibition errors in the anti-saccade task were the primary outcome variable, in addition, the percentage of anticipatory errors was measured.
Sz patients showed more inhibition errors than HC and BPD (
p
<
.001 and
p
<
.05 resp.), whereas BPD patients scored in between Sz and HC. The difference with HC was significant as well (
p
<
.05). BPD patients with psychotic-like symptoms showed more inhibition errors than BPD patients without these symptoms (
p
<
.05). BPD patients showed more anticipatory errors than HC (
p
<
.001), whereas Sz patients did not (
p
<
.26).
The data demonstrate that inhibition deficits, as measured with anti-saccadic eye movement task, may be characteristic among BPD patients and in a larger extent in patients with psychotic-like symptoms. This inhibition deficit was distinct from a general predisposition to response impulsively as measured by anticipatory errors, which was found in the whole group of BPD patients. Psychotic-like symptoms may be an important target dimension for future BPD research and treatment.]]></abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>17889419</pmid><doi>10.1016/j.pnpbp.2007.08.020</doi><tpages>7</tpages></addata></record> |
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| ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 2008, Vol.32 (1), p.267-273 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Adult and adolescent clinical studies Analysis of Variance Biological and medical sciences Borderline personality disorder Borderline Personality Disorder - complications Electrooculography - methods Eye Movements - physiology Female Humans Impulsivity Inhibition Inhibition (Psychology) Male Medical sciences Neuropharmacology Neuropsychological Tests Personality disorders Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychometrics Psychopathology. Psychiatry Psychoses Psychosis Psychotic Disorders - economics Saccades Schizophrenia Schizophrenia - physiopathology |
| title | Inhibition errors in borderline personality disorder with psychotic-like symptoms |
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