Insulin-like Growth Factor Binding Proteins IGFBP3, IGFBP4, and IGFBP5 Predict Endocrine Responsiveness in Patients with Ovarian Cancer

Purpose: This study sought to explore the predictive value of the insulin-like growth factor (IGF) binding proteins (IGFBP) as markers of response in ovarian cancer patients treated with the aromatase inhibitor letrozole. Experimental Design: IGFBP mRNA expression in cell lines was measured by quant...

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Veröffentlicht in:	Clinical cancer research 2007-03, Vol.13 (5), p.1438-1444
Hauptverfasser:	WALKER, Graeme, MACLEOD, Kenneth, WILLIAMS, Alistair R. W, CAMERON, David A, SMYTH, John F, LANGDON, Simon P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences CA-125 Antigen - blood Cell Line, Tumor Drug Resistance, Neoplasm Estradiol - metabolism Female Female genital diseases Gynecology. Andrology. Obstetrics Humans IGFBPs Immunohistochemistry Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor Binding Protein 4 - biosynthesis Insulin-Like Growth Factor Binding Protein 5 - biosynthesis Insulin-Like Growth Factor Binding Proteins - biosynthesis Insulin-Like Growth Factor Binding Proteins - drug effects letrozole Medical sciences Nitriles - therapeutic use Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Pharmacology. Drug treatments predictive marker Receptors, Estrogen - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Triazoles - therapeutic use Tumors
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