Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system

Synaptosomes and plasma membranes obtained from rat brain display ectoenzymatic hydrolytic activity responsible for hydrolysis of the neurotransmitter/neuroregulatory nucleotides diadenosine polyphosphates. Intact synaptosomes and plasma and synaptic membranes isolated by sucrose-gradient ultracentr...

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Veröffentlicht in:	Neurochemistry international 2007-03, Vol.50 (4), p.581-590
Hauptverfasser:	Asensio, Aaron C., Rodríguez-Ferrer, Carmen R., Castañeyra-Perdomo, Agustín, Oaknin, Sol, Rotllán, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Ageing Aging - metabolism Animals Biological and medical sciences Cell Membrane - enzymology Cell Membrane - ultrastructure Central Nervous System - enzymology Central Nervous System - ultrastructure Diadenosine polyphosphates Dinucleoside Phosphates - metabolism E-NPP enzymes Enzyme Activation - physiology Extracellular Fluid - enzymology Fundamental and applied biological sciences. Psychology Hydrolysis Kinetics Male Neurons - enzymology Neurons - ultrastructure Neuroprotective Agents - metabolism Phosphoric Diester Hydrolases - metabolism Plasma membranes Pyrophosphatases - metabolism Rats Rats, Wistar Synaptic membranes Synaptic Membranes - enzymology Synaptic Membranes - ultrastructure Synaptosomes - enzymology Synaptosomes - ultrastructure Vertebrates: nervous system and sense organs
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