Factor B structure provides insights into activation of the central protease of the complement system

Factor B is the central protease of the complement system of immune defense. Here, we present the crystal structure of human factor B at 2.3-Å resolution, which reveals how the five-domain proenzyme is kept securely inactive. The canonical activation helix of the Von Willebrand factor A (VWA) domain...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature structural & molecular biology 2007-03, Vol.14 (3), p.224-228
Hauptverfasser:	Milder, Fin J, Gomes, Lucio, Schouten, Arie, Janssen, Bert J C, Huizinga, Eric G, Romijn, Roland A, Hemrika, Wieger, Roos, Anja, Daha, Mohamed R, Gros, Piet
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Binding sites Biochemistry Biological Microscopy Biomedical and Life Sciences Catalytic Domain Cell adhesion & migration Complement C3-C5 Convertases - chemistry Complement Factor B - chemistry Complement Factor B - metabolism Complement System Proteins - immunology Crystal structure Crystallography, X-Ray DNA binding proteins Enzyme Activation Human factors Humans Immune response Life Sciences Membrane Biology Metal ions Models, Molecular Molecular biology Molecular structure Physiological aspects Proteases Protein Structure Protein Structure, Secondary Protein Structure, Tertiary Regulatory Sequences, Nucleic Acid - genetics Structure Structure-Activity Relationship von Willebrand Factor - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!