Effects of Aging on Lower Urinary Tract and Pelvic Floor Function in Nulliparous Women
OBJECTIVE:To evaluate the effects of aging, independent of parity, on pelvic organ and urethral support, urethral function, and levator function in a sample of nulliparous women. METHODS:A cohort of 82 nulliparous women, aged 21–70 years, were recruited from the community through advertisements. Sub...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2007-03, Vol.109 (3), p.715-720 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Trowbridge, Elisa Rodriguez Wei, John T Fenner, Dee E Ashton-Miller, James A DeLancey, John O. L |
| description | OBJECTIVE:To evaluate the effects of aging, independent of parity, on pelvic organ and urethral support, urethral function, and levator function in a sample of nulliparous women.
METHODS:A cohort of 82 nulliparous women, aged 21–70 years, were recruited from the community through advertisements. Subjects underwent pelvic examination using pelvic organ prolapse quantification, urethral angles by cotton-tipped swab, and multichannel urodynamics and uroflow. Vaginal closure force was quantified using an instrumented vaginal speculum. Subjects were grouped into five age categories and analyses performed using t tests, Fisher exact tests, Kruskal-Wallace, and Pearson correlation coefficients. Multiple linear regression modeling was performed to adjust for factors that might confound the results of our primary outcomes.
RESULTS:Increasing age was associated with decreasing maximal urethral closure pressure (r=–0.758, P |
| doi_str_mv | 10.1097/01.AOG.0000257074.98122.69 |
| format | Article |
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METHODS:A cohort of 82 nulliparous women, aged 21–70 years, were recruited from the community through advertisements. Subjects underwent pelvic examination using pelvic organ prolapse quantification, urethral angles by cotton-tipped swab, and multichannel urodynamics and uroflow. Vaginal closure force was quantified using an instrumented vaginal speculum. Subjects were grouped into five age categories and analyses performed using t tests, Fisher exact tests, Kruskal-Wallace, and Pearson correlation coefficients. Multiple linear regression modeling was performed to adjust for factors that might confound the results of our primary outcomes.
RESULTS:Increasing age was associated with decreasing maximal urethral closure pressure (r=–0.758, P<.001) with a 15-cm-H2O decrease in pressure per decade. Pelvic organ support as measured by pelvic organ prolapse quantification did not differ by age group. Levator function as measured by resting vaginal closure force and augmentation of vaginal closure force also did not change with increasing age.
CONCLUSION:In a sample of nulliparous women between 21 and 70 years of age maximal urethral closure pressure in the senescent urethra was 40% of that in the young urethra; increasing age did not affect clinical measures of pelvic organ support, urethral support, and levator function.
LEVEL OF EVIDENCE:III</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/01.AOG.0000257074.98122.69</identifier><identifier>PMID: 17329525</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Adult ; Age Factors ; Aged ; Aging - physiology ; Biological and medical sciences ; Body Mass Index ; Cross-Sectional Studies ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Parity - physiology ; Pelvic Floor - physiology ; Pregnancy ; Pressure ; Urethra - physiology ; Urodynamics - physiology</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2007-03, Vol.109 (3), p.715-720</ispartof><rights>2007 The American College of Obstetricians and Gynecologists</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5100-95e89b28ee9e9898152d819f6cd2415eb06cfa4febd6d494b65d1db2ddcb6c153</citedby><cites>FETCH-LOGICAL-c5100-95e89b28ee9e9898152d819f6cd2415eb06cfa4febd6d494b65d1db2ddcb6c153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18556869$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17329525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trowbridge, Elisa Rodriguez</creatorcontrib><creatorcontrib>Wei, John T</creatorcontrib><creatorcontrib>Fenner, Dee E</creatorcontrib><creatorcontrib>Ashton-Miller, James A</creatorcontrib><creatorcontrib>DeLancey, John O. L</creatorcontrib><title>Effects of Aging on Lower Urinary Tract and Pelvic Floor Function in Nulliparous Women</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>OBJECTIVE:To evaluate the effects of aging, independent of parity, on pelvic organ and urethral support, urethral function, and levator function in a sample of nulliparous women.
METHODS:A cohort of 82 nulliparous women, aged 21–70 years, were recruited from the community through advertisements. Subjects underwent pelvic examination using pelvic organ prolapse quantification, urethral angles by cotton-tipped swab, and multichannel urodynamics and uroflow. Vaginal closure force was quantified using an instrumented vaginal speculum. Subjects were grouped into five age categories and analyses performed using t tests, Fisher exact tests, Kruskal-Wallace, and Pearson correlation coefficients. Multiple linear regression modeling was performed to adjust for factors that might confound the results of our primary outcomes.
RESULTS:Increasing age was associated with decreasing maximal urethral closure pressure (r=–0.758, P<.001) with a 15-cm-H2O decrease in pressure per decade. Pelvic organ support as measured by pelvic organ prolapse quantification did not differ by age group. Levator function as measured by resting vaginal closure force and augmentation of vaginal closure force also did not change with increasing age.
CONCLUSION:In a sample of nulliparous women between 21 and 70 years of age maximal urethral closure pressure in the senescent urethra was 40% of that in the young urethra; increasing age did not affect clinical measures of pelvic organ support, urethral support, and levator function.
LEVEL OF EVIDENCE:III</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parity - physiology</subject><subject>Pelvic Floor - physiology</subject><subject>Pregnancy</subject><subject>Pressure</subject><subject>Urethra - physiology</subject><subject>Urodynamics - physiology</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFtvFCEUgInR2HX1Lxhiom8zAjMM4Num6VaTjfWhtX0jDJcWZWGFmTb999LdTZaXE3K-c_sA-IRRi5FgXxFuV1eXLaqPUIZY3wqOCWkH8QosMGddQ7ru7jVY1LxoGO_7M_CulD-Vx4Po3oIzzDoiKKEL8PvCOaunApODq3sf72GKcJOebIY32UeVn-F1VnqCKhr4y4ZHr-E6pJTheo568pX2Ef6cQ_A7ldNc4G3a2vgevHEqFPvhGJfgZn1xff692Vxd_jhfbRpNMUKNoJaLkXBrhRW8XkGJ4Vi4QRvSY2pHNGinemdHM5he9ONADTYjMUaPg8a0W4Ivh767nP7Ntkxy64u2Iaho6zKSIVIVsb6C3w6gzqmUbJ3cZb-t50mM5ItVibCsVuXJqtxbldXYEnw8TpnHrTWn0qPGCnw-AqpoFVxWUfty4jilA9836g_cUwqTzeVvmKtp-WBVmB72owdCUUMQYqirv-ZlGdT9Bzg1j_U</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Trowbridge, Elisa Rodriguez</creator><creator>Wei, John T</creator><creator>Fenner, Dee E</creator><creator>Ashton-Miller, James A</creator><creator>DeLancey, John O. L</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Effects of Aging on Lower Urinary Tract and Pelvic Floor Function in Nulliparous Women</title><author>Trowbridge, Elisa Rodriguez ; Wei, John T ; Fenner, Dee E ; Ashton-Miller, James A ; DeLancey, John O. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5100-95e89b28ee9e9898152d819f6cd2415eb06cfa4febd6d494b65d1db2ddcb6c153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parity - physiology</topic><topic>Pelvic Floor - physiology</topic><topic>Pregnancy</topic><topic>Pressure</topic><topic>Urethra - physiology</topic><topic>Urodynamics - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trowbridge, Elisa Rodriguez</creatorcontrib><creatorcontrib>Wei, John T</creatorcontrib><creatorcontrib>Fenner, Dee E</creatorcontrib><creatorcontrib>Ashton-Miller, James A</creatorcontrib><creatorcontrib>DeLancey, John O. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trowbridge, Elisa Rodriguez</au><au>Wei, John T</au><au>Fenner, Dee E</au><au>Ashton-Miller, James A</au><au>DeLancey, John O. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Aging on Lower Urinary Tract and Pelvic Floor Function in Nulliparous Women</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2007-03</date><risdate>2007</risdate><volume>109</volume><issue>3</issue><spage>715</spage><epage>720</epage><pages>715-720</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>OBJECTIVE:To evaluate the effects of aging, independent of parity, on pelvic organ and urethral support, urethral function, and levator function in a sample of nulliparous women.
METHODS:A cohort of 82 nulliparous women, aged 21–70 years, were recruited from the community through advertisements. Subjects underwent pelvic examination using pelvic organ prolapse quantification, urethral angles by cotton-tipped swab, and multichannel urodynamics and uroflow. Vaginal closure force was quantified using an instrumented vaginal speculum. Subjects were grouped into five age categories and analyses performed using t tests, Fisher exact tests, Kruskal-Wallace, and Pearson correlation coefficients. Multiple linear regression modeling was performed to adjust for factors that might confound the results of our primary outcomes.
RESULTS:Increasing age was associated with decreasing maximal urethral closure pressure (r=–0.758, P<.001) with a 15-cm-H2O decrease in pressure per decade. Pelvic organ support as measured by pelvic organ prolapse quantification did not differ by age group. Levator function as measured by resting vaginal closure force and augmentation of vaginal closure force also did not change with increasing age.
CONCLUSION:In a sample of nulliparous women between 21 and 70 years of age maximal urethral closure pressure in the senescent urethra was 40% of that in the young urethra; increasing age did not affect clinical measures of pelvic organ support, urethral support, and levator function.
LEVEL OF EVIDENCE:III</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>17329525</pmid><doi>10.1097/01.AOG.0000257074.98122.69</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 2007-03, Vol.109 (3), p.715-720 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Age Factors Aged Aging - physiology Biological and medical sciences Body Mass Index Cross-Sectional Studies Female Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Parity - physiology Pelvic Floor - physiology Pregnancy Pressure Urethra - physiology Urodynamics - physiology |
| title | Effects of Aging on Lower Urinary Tract and Pelvic Floor Function in Nulliparous Women |
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