Polymorphisms Within the IL‐1 Gene Cluster: Effects on Cytokine Profiles in Peripheral Blood and Whole Blood Cell Cultures of Patients With Aggressive Periodontitis, Juvenile Idiopathic Arthritis, and Rheumatoid Arthritis

Background: Genetic polymorphisms of cytokines have been associated with the susceptibility, severity, and clinical outcome of inflammatory diseases, such as periodontitis and chronic arthritis. An important question to address is how interleukin (IL)‐1 polymorphisms affect the cytokine profiles of...

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Veröffentlicht in:	Journal of periodontology (1970) 2007-03, Vol.78 (3), p.475-492
Hauptverfasser:	Havemose‐Poulsen, Anne, Sørensen, Lars Korsbæk, Bendtzen, Klaus, Holmstrup, Palle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Analysis of Variance Arthritis, Juvenile - blood Arthritis, Juvenile - genetics Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - genetics Biological and medical sciences Blood Cells - immunology Case-Control Studies Cell culture Cells, Cultured Chronic Disease cytokines Cytokines - blood Dentistry Diseases of the osteoarticular system European Continental Ancestry Group Female Gene Frequency Humans Inflammatory joint diseases Interleukin-1 - genetics Interleukins - blood interleukin‐1 Lymphotoxin-alpha - blood Male Medical sciences Minisatellite Repeats Multigene Family periodontitis Periodontitis - blood Periodontitis - genetics plasma polymorphism Polymorphism, Single Nucleotide rheumatoid arthritis Tumor Necrosis Factor-alpha - blood
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