Longitudinal analysis of HIV type 1 subtype C envelope sequences from south africa
The envelope genes of 23 subtype C viral isolates from five individuals with early HIV-1 infection, followed for 2-4 years, were sequenced, analyzed, and correlated to coreceptor usage. Isolates from three participants used the CCR5 coreceptor at all time points, with no significant adaptations in t...
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| Veröffentlicht in: | AIDS research and human retroviruses 2007-02, Vol.23 (2), p.316-321 |
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| container_title | AIDS research and human retroviruses |
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| creator | COETZER, Mia CILLIERS, Tonie PAPATHANASOPOULOS, Maria RAMJEE, Gita SALIM ABDOOL KARIM WILLIAMSON, Carolyn MORRIS, Lynn |
| description | The envelope genes of 23 subtype C viral isolates from five individuals with early HIV-1 infection, followed for 2-4 years, were sequenced, analyzed, and correlated to coreceptor usage. Isolates from three participants used the CCR5 coreceptor at all time points, with no significant adaptations in the variable loop lengths, predicted N-linked glycosylation sites, or predicted change in sensitivity to monoclonal antibodies with disease progression. However, two individuals, Du151 and Du179, who had previously been shown to be dually infected with two phylogenetically distinct subtype C strains, were able to use CXCR4 with disease progression. The intraperson genetic diversity was 9% for Du151 and 3% for Du179 compared to |
| doi_str_mv | 10.1089/aid.2006.0207 |
| format | Article |
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Isolates from three participants used the CCR5 coreceptor at all time points, with no significant adaptations in the variable loop lengths, predicted N-linked glycosylation sites, or predicted change in sensitivity to monoclonal antibodies with disease progression. However, two individuals, Du151 and Du179, who had previously been shown to be dually infected with two phylogenetically distinct subtype C strains, were able to use CXCR4 with disease progression. The intraperson genetic diversity was 9% for Du151 and 3% for Du179 compared to <2% for participants who did not undergo a coreceptor switch. In both cases this coreceptor switch was associated with specific amino acid changes in the crown, an increased net amino acid charge in the V3 loop, and an increase in the length of the V1 region.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.2006.0207</identifier><identifier>PMID: 17331039</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS/HIV ; Biological and medical sciences ; Disease Progression ; Evolution, Molecular ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Products, env - chemistry ; Gene Products, env - classification ; Genes, env - genetics ; Genetic aspects ; Health aspects ; HIV - genetics ; HIV infection ; HIV-1 - classification ; HIV-1 - genetics ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Phylogeny ; Prevention ; Receptors, CCR5 - genetics ; Receptors, CXCR4 - genetics ; Retrovirus ; Risk factors ; South Africa ; Viral diseases ; Viral envelopes ; Virology</subject><ispartof>AIDS research and human retroviruses, 2007-02, Vol.23 (2), p.316-321</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-758609f484bfc97615c9501e0f9ccbb6ed9c7cb574b866c1153acf97e30b170d3</citedby><cites>FETCH-LOGICAL-c380t-758609f484bfc97615c9501e0f9ccbb6ed9c7cb574b866c1153acf97e30b170d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18615684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17331039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COETZER, Mia</creatorcontrib><creatorcontrib>CILLIERS, Tonie</creatorcontrib><creatorcontrib>PAPATHANASOPOULOS, Maria</creatorcontrib><creatorcontrib>RAMJEE, Gita</creatorcontrib><creatorcontrib>SALIM ABDOOL KARIM</creatorcontrib><creatorcontrib>WILLIAMSON, Carolyn</creatorcontrib><creatorcontrib>MORRIS, Lynn</creatorcontrib><title>Longitudinal analysis of HIV type 1 subtype C envelope sequences from south africa</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>The envelope genes of 23 subtype C viral isolates from five individuals with early HIV-1 infection, followed for 2-4 years, were sequenced, analyzed, and correlated to coreceptor usage. Isolates from three participants used the CCR5 coreceptor at all time points, with no significant adaptations in the variable loop lengths, predicted N-linked glycosylation sites, or predicted change in sensitivity to monoclonal antibodies with disease progression. However, two individuals, Du151 and Du179, who had previously been shown to be dually infected with two phylogenetically distinct subtype C strains, were able to use CXCR4 with disease progression. The intraperson genetic diversity was 9% for Du151 and 3% for Du179 compared to <2% for participants who did not undergo a coreceptor switch. In both cases this coreceptor switch was associated with specific amino acid changes in the crown, an increased net amino acid charge in the V3 loop, and an increase in the length of the V1 region.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Disease Progression</subject><subject>Evolution, Molecular</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Products, env - chemistry</subject><subject>Gene Products, env - classification</subject><subject>Genes, env - genetics</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>HIV - genetics</subject><subject>HIV infection</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Phylogeny</subject><subject>Prevention</subject><subject>Receptors, CCR5 - genetics</subject><subject>Receptors, CXCR4 - genetics</subject><subject>Retrovirus</subject><subject>Risk factors</subject><subject>South Africa</subject><subject>Viral diseases</subject><subject>Viral envelopes</subject><subject>Virology</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U2LFDEQBuCwKO7sx3GvEhC99ViVdOfjuAzqLgwIol5DOp2skZ7OmHQL8-_NOAN73EuqDg9VoV5C7hDWCEp_tHFYMwCxBgbygqxQc2xUC90rsgKldMMY05fkqpTfAKAZ696QS5ScI3C9It-2aXqK8zLEyY7U1udQYqEp0IfHn3Q-7D1FWpb-f7ehfvrrx1Tb4v8sfnK-0JDTjpa0zL-oDTk6e0NeBzsWf3uu1-TH50_fNw_N9uuXx839tnFcwdzITgnQoVVtH5yWAjunO0APQTvX98IP2knXd7LtlRAOsePWBS09hx4lDPyafDjN3edUP1Nms4vF-XG0k09LMRIYQ6W6FyFqAQgSK3x3gk929CZOIc3ZuiM296hRtHWkqKo5KZdTKdkHs89xZ_PBIJhjJqZmYo6ZmGMm1b89r1_6nR-e9TmECt6fgS3OjiHbycXy7FS9jVAt_wdcsZJt</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>COETZER, Mia</creator><creator>CILLIERS, Tonie</creator><creator>PAPATHANASOPOULOS, Maria</creator><creator>RAMJEE, Gita</creator><creator>SALIM ABDOOL KARIM</creator><creator>WILLIAMSON, Carolyn</creator><creator>MORRIS, Lynn</creator><general>Liebert</general><general>Mary Ann Liebert, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Longitudinal analysis of HIV type 1 subtype C envelope sequences from south africa</title><author>COETZER, Mia ; CILLIERS, Tonie ; PAPATHANASOPOULOS, Maria ; RAMJEE, Gita ; SALIM ABDOOL KARIM ; WILLIAMSON, Carolyn ; MORRIS, Lynn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-758609f484bfc97615c9501e0f9ccbb6ed9c7cb574b866c1153acf97e30b170d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Disease Progression</topic><topic>Evolution, Molecular</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Products, env - chemistry</topic><topic>Gene Products, env - classification</topic><topic>Genes, env - genetics</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>HIV - genetics</topic><topic>HIV infection</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Phylogeny</topic><topic>Prevention</topic><topic>Receptors, CCR5 - genetics</topic><topic>Receptors, CXCR4 - genetics</topic><topic>Retrovirus</topic><topic>Risk factors</topic><topic>South Africa</topic><topic>Viral diseases</topic><topic>Viral envelopes</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COETZER, Mia</creatorcontrib><creatorcontrib>CILLIERS, Tonie</creatorcontrib><creatorcontrib>PAPATHANASOPOULOS, Maria</creatorcontrib><creatorcontrib>RAMJEE, Gita</creatorcontrib><creatorcontrib>SALIM ABDOOL KARIM</creatorcontrib><creatorcontrib>WILLIAMSON, Carolyn</creatorcontrib><creatorcontrib>MORRIS, Lynn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COETZER, Mia</au><au>CILLIERS, Tonie</au><au>PAPATHANASOPOULOS, Maria</au><au>RAMJEE, Gita</au><au>SALIM ABDOOL KARIM</au><au>WILLIAMSON, Carolyn</au><au>MORRIS, Lynn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal analysis of HIV type 1 subtype C envelope sequences from south africa</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>23</volume><issue>2</issue><spage>316</spage><epage>321</epage><pages>316-321</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>The envelope genes of 23 subtype C viral isolates from five individuals with early HIV-1 infection, followed for 2-4 years, were sequenced, analyzed, and correlated to coreceptor usage. Isolates from three participants used the CCR5 coreceptor at all time points, with no significant adaptations in the variable loop lengths, predicted N-linked glycosylation sites, or predicted change in sensitivity to monoclonal antibodies with disease progression. However, two individuals, Du151 and Du179, who had previously been shown to be dually infected with two phylogenetically distinct subtype C strains, were able to use CXCR4 with disease progression. The intraperson genetic diversity was 9% for Du151 and 3% for Du179 compared to <2% for participants who did not undergo a coreceptor switch. In both cases this coreceptor switch was associated with specific amino acid changes in the crown, an increased net amino acid charge in the V3 loop, and an increase in the length of the V1 region.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>17331039</pmid><doi>10.1089/aid.2006.0207</doi><tpages>6</tpages></addata></record> |
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| ispartof | AIDS research and human retroviruses, 2007-02, Vol.23 (2), p.316-321 |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV Biological and medical sciences Disease Progression Evolution, Molecular Female Fundamental and applied biological sciences. Psychology Gene Products, env - chemistry Gene Products, env - classification Genes, env - genetics Genetic aspects Health aspects HIV - genetics HIV infection HIV-1 - classification HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Medical sciences Microbiology Miscellaneous Molecular Sequence Data Phylogeny Prevention Receptors, CCR5 - genetics Receptors, CXCR4 - genetics Retrovirus Risk factors South Africa Viral diseases Viral envelopes Virology |
| title | Longitudinal analysis of HIV type 1 subtype C envelope sequences from south africa |
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