Changes in platelet function, hemostasis, and prostaglandin expression after treatment with nonsteroidal anti-inflammatory drugs with various cyclooxygenase selectivities in dogs

To determine the effects of nonsteroidal anti-inflammatory drugs of various cyclooxygenase selectivities on hemostasis and prostaglandin expression in dogs. 8 client-owned dogs with clinical signs of osteoarthritis. Dogs received aspirin (5 mg/kg, PO, q 12 h), carprofen (4 mg/kg, PO, q 24 h), deraco...

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Veröffentlicht in:	American journal of veterinary research 2007-03, Vol.68 (3), p.251-257
Hauptverfasser:	Brainard, B.M, Meredith, C.P, Callan, M.B, Budsberg, S.C, Shofer, F.S, Driessen, B, Otto, C.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspirin - pharmacology blood chemistry blood clots blood platelets bloot clot strength Carbazoles - pharmacology Cross-Over Studies Cyclooxygenase Inhibitors - pharmacology dog diseases Dog Diseases - drug therapy Dogs Female Gene Expression Regulation hemostasis Hemostasis - drug effects hormone secretion lipopolysaccharides Male metabolites nonsteroidal anti-inflammatory agents osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - veterinary pets pharmacokinetics platelet aggregation Platelet Aggregation - drug effects prostaglandin synthase prostaglandins Prostaglandins - genetics Prostaglandins - metabolism Sulfonamides - pharmacology Thiazines - pharmacology Thiazoles - pharmacology thrombelastography thromboxanes
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