Stabilizing Ionic Interactions in a Full-consensus Ankyrin Repeat Protein

Full-consensus designed ankyrin repeat proteins (DARPins), in which randomized positions of the previously described DARPin library have been fixed, are characterized. They show exceptionally high thermodynamic stabilities, even when compared to members of consensus DARPin libraries and even more so...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular biology 2008-02, Vol.376 (1), p.232-240
Hauptverfasser:	Merz, Tobias, Wetzel, Svava K., Firbank, Susan, Plückthun, Andreas, Grütter, Markus G., Mittl, Peer R.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Ankyrin Repeat Ankyrins - chemistry Ankyrins - metabolism Consensus Sequence Crystallography, X-Ray Hot Temperature Models, Molecular Molecular Sequence Data Protein Denaturation protein stability Protein Structure, Tertiary repeat protein salt bridge Sequence Alignment thermodynamic stability X-ray crystallography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!