The sliding threshold of modification hypothesis: Application to the effect of hypothyroidism or chronic psychosocial stress and nicotine on synaptic plasticity

The Bienenstock, Cooper, and Munro (BCM) theory or the sliding threshold model can be used to explain the changes in synaptic plasticity related to learning and memory, namely long-term potentiation (LTP) and depression (LTD). In this study, we applied synaptic plasticity changes induced by either c...

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Veröffentlicht in:	Neuroscience letters 2008-01, Vol.430 (3), p.203-206
Hauptverfasser:	Alzoubi, K.H., Aleisa, A.M., Alkadhi, K.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetized rat Animals Biological and medical sciences Chronic Disease Disease Models, Animal Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - physiology Hypothyroidism - physiopathology Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Long-Term Synaptic Depression - drug effects Long-Term Synaptic Depression - physiology LTD LTP Male Models, Neurological Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Nicotine - pharmacology Nicotinic Agonists - pharmacology Phosphoric Monoester Hydrolases - metabolism Phosphotransferases - metabolism Rats Rats, Wistar Sliding threshold Stress, Psychological - physiopathology Synaptic Transmission - drug effects Synaptic Transmission - physiology Thyroid Hormones - metabolism Vertebrates: nervous system and sense organs
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