Neuritogenic Activity of Gangliosides from Echinoderms and Their Structure–Activity Relationship

The effects of the gangliosides isolated from echinoderms on the neuritogenesis of a rat pheochromocytoma cell line (PC-12 cells) in the presence of nerve growth factor were investigated. The results show that they displayed neuritogenic activity. Based on the observed results, a structure–activity...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2007, Vol.55(3), pp.462-463
Hauptverfasser:	Kaneko, Masafumi, Yamada, Koji, Miyamoto, Tomofumi, Inagaki, Masanori, Higuchi, Ryuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals echinoderm Echinodermata - chemistry ganglioside Gangliosides - chemistry Gangliosides - pharmacology Molecular Structure Nerve Growth Factor - pharmacology neuritogenic activity PC12 Cells Pheochromocytoma - drug therapy Rats Structure-Activity Relationship
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Zusammenfassung:	The effects of the gangliosides isolated from echinoderms on the neuritogenesis of a rat pheochromocytoma cell line (PC-12 cells) in the presence of nerve growth factor were investigated. The results show that they displayed neuritogenic activity. Based on the observed results, a structure–activity relationship has been established.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.55.462