Predator Odor-Induced Conditioned Fear Involves the Basolateral and Medial Amygdala
The basolateral (BLA) and medial nucleus (MeA) of the amygdala participate in the modulation of unconditioned fear induced by predator odor. However, the specific role of these amygdalar nuclei in predator odor-induced fear memory is not known. Therefore, fiber-sparing lesions or temporary inactivat...
Gespeichert in:
| Veröffentlicht in: | Behavioral neuroscience 2007-02, Vol.121 (1), p.100-110 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 110 |
|---|---|
| container_issue | 1 |
| container_start_page | 100 |
| container_title | Behavioral neuroscience |
| container_volume | 121 |
| creator | Takahashi, Lorey K Hubbard, David T Lee, Iris Dar, Yasmin Sipes, Sara M |
| description | The basolateral (BLA) and medial nucleus (MeA) of the amygdala participate in the modulation of unconditioned fear induced by predator odor. However, the specific role of these amygdalar nuclei in predator odor-induced fear memory is not known. Therefore, fiber-sparing lesions or temporary inactivation of the BLA or MeA were made either prior to or after exposure to cat odor, and conditioned contextual fear behavior was examined the next day. BLA and MeA lesions produced significant reductions in cat odor-induced unconditioned and conditioned fear-related behavior. In addition, temporary pharmacological neural inactivation methods occurring after exposure to cat odor revealed subtle behavioral alterations indicative of a role of the BLA in fear memory consolidation but not memory retrieval. In contrast, the MeA appears to play a specific role in retrieval but not consolidation. Results show that the BLA participates in the conditioned and unconditioned cat odor stimulus association that underlies fear memory, underscore a novel role of the MeA in predator odor contextual conditioning, and demonstrate different roles of the BLA and MeA in modulating consolidation and retrieval of predator odor fear memory. |
| doi_str_mv | 10.1037/0735-7044.121.1.100 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70217926</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19757100</sourcerecordid><originalsourceid>FETCH-LOGICAL-a485t-6cd8d4060dce037fc0fdffdc72a4a36f74c9b6f5d665b7e7201e23ee19b28d803</originalsourceid><addsrcrecordid>eNqF0VFrFDEQB_Agij2rn0CQRahP7jnZZJPdx3rYelCpoD6H2WRWt-wlZ7JbuG9vrndYLKLMQ_LwywyTP2MvOSw5CP0OtKhLDVIuecWXuQAesQVvRVsCNPIxW_wWJ-xZSjcAIEHWT9kJ16KSUMsF-_I5ksMpxOLahViuvZstuWIVvBumIfh8vyCMxdrfhvGWUjH9oOI9pjDiRBHHAr0rPpEb8vV8s_vucMTn7EmPY6IXx_OUfbv48HX1sby6vlyvzq9KlE09lcq6xklQ4CzlfXoLvet7Z3WFEoXqtbRtp_raKVV3mnQFnCpBxNuualwD4pS9OfTdxvBzpjSZzZAsjSN6CnMyGiqu20r9F_JW1zp_X4avH8CbMEeflzCKS6mUBv4vVIFomkYLnZE4IBtDSpF6s43DBuPOcDD7-Mw-HLMPx-T4TK67-a-OreduQ-7-zTGvDM6OAJPFsY_o7ZDuXVNL3bR79_bgcItmm3YW4zTYkZKdYyQ_mc7TH3PP_s4fuF9_27y8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>614466701</pqid></control><display><type>article</type><title>Predator Odor-Induced Conditioned Fear Involves the Basolateral and Medial Amygdala</title><source>MEDLINE</source><source>EBSCOhost APA PsycARTICLES</source><creator>Takahashi, Lorey K ; Hubbard, David T ; Lee, Iris ; Dar, Yasmin ; Sipes, Sara M</creator><contributor>Disterhoft, John F</contributor><creatorcontrib>Takahashi, Lorey K ; Hubbard, David T ; Lee, Iris ; Dar, Yasmin ; Sipes, Sara M ; Disterhoft, John F</creatorcontrib><description>The basolateral (BLA) and medial nucleus (MeA) of the amygdala participate in the modulation of unconditioned fear induced by predator odor. However, the specific role of these amygdalar nuclei in predator odor-induced fear memory is not known. Therefore, fiber-sparing lesions or temporary inactivation of the BLA or MeA were made either prior to or after exposure to cat odor, and conditioned contextual fear behavior was examined the next day. BLA and MeA lesions produced significant reductions in cat odor-induced unconditioned and conditioned fear-related behavior. In addition, temporary pharmacological neural inactivation methods occurring after exposure to cat odor revealed subtle behavioral alterations indicative of a role of the BLA in fear memory consolidation but not memory retrieval. In contrast, the MeA appears to play a specific role in retrieval but not consolidation. Results show that the BLA participates in the conditioned and unconditioned cat odor stimulus association that underlies fear memory, underscore a novel role of the MeA in predator odor contextual conditioning, and demonstrate different roles of the BLA and MeA in modulating consolidation and retrieval of predator odor fear memory.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.121.1.100</identifier><identifier>PMID: 17324054</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Amygdala ; Amygdala - anatomy & histology ; Amygdala - drug effects ; Amygdala - injuries ; Amygdala - physiology ; Animal ; Animals ; Avoidance Learning - physiology ; Basolateral Amygdala ; Behavior ; Behavior, Animal ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Conditioned Fear ; Conditioning, Classical - drug effects ; Conditioning, Classical - physiology ; Fear ; Fear & phobias ; Freezing Reaction, Cataleptic - drug effects ; Fundamental and applied biological sciences. Psychology ; GABA Agonists - pharmacology ; Male ; Memory ; Muscimol - pharmacology ; Neurosciences ; Odorants ; Odors ; Olfactory Perception ; Predatory Behavior - drug effects ; Predatory Behavior - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Long-Evans</subject><ispartof>Behavioral neuroscience, 2007-02, Vol.121 (1), p.100-110</ispartof><rights>2007 American Psychological Association</rights><rights>2007 INIST-CNRS</rights><rights>Copyright (c) 2007 APA, all rights reserved.</rights><rights>Copyright American Psychological Association Feb 2007</rights><rights>2007, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a485t-6cd8d4060dce037fc0fdffdc72a4a36f74c9b6f5d665b7e7201e23ee19b28d803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18547894$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17324054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Disterhoft, John F</contributor><creatorcontrib>Takahashi, Lorey K</creatorcontrib><creatorcontrib>Hubbard, David T</creatorcontrib><creatorcontrib>Lee, Iris</creatorcontrib><creatorcontrib>Dar, Yasmin</creatorcontrib><creatorcontrib>Sipes, Sara M</creatorcontrib><title>Predator Odor-Induced Conditioned Fear Involves the Basolateral and Medial Amygdala</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>The basolateral (BLA) and medial nucleus (MeA) of the amygdala participate in the modulation of unconditioned fear induced by predator odor. However, the specific role of these amygdalar nuclei in predator odor-induced fear memory is not known. Therefore, fiber-sparing lesions or temporary inactivation of the BLA or MeA were made either prior to or after exposure to cat odor, and conditioned contextual fear behavior was examined the next day. BLA and MeA lesions produced significant reductions in cat odor-induced unconditioned and conditioned fear-related behavior. In addition, temporary pharmacological neural inactivation methods occurring after exposure to cat odor revealed subtle behavioral alterations indicative of a role of the BLA in fear memory consolidation but not memory retrieval. In contrast, the MeA appears to play a specific role in retrieval but not consolidation. Results show that the BLA participates in the conditioned and unconditioned cat odor stimulus association that underlies fear memory, underscore a novel role of the MeA in predator odor contextual conditioning, and demonstrate different roles of the BLA and MeA in modulating consolidation and retrieval of predator odor fear memory.</description><subject>Amygdala</subject><subject>Amygdala - anatomy & histology</subject><subject>Amygdala - drug effects</subject><subject>Amygdala - injuries</subject><subject>Amygdala - physiology</subject><subject>Animal</subject><subject>Animals</subject><subject>Avoidance Learning - physiology</subject><subject>Basolateral Amygdala</subject><subject>Behavior</subject><subject>Behavior, Animal</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Conditioned Fear</subject><subject>Conditioning, Classical - drug effects</subject><subject>Conditioning, Classical - physiology</subject><subject>Fear</subject><subject>Fear & phobias</subject><subject>Freezing Reaction, Cataleptic - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA Agonists - pharmacology</subject><subject>Male</subject><subject>Memory</subject><subject>Muscimol - pharmacology</subject><subject>Neurosciences</subject><subject>Odorants</subject><subject>Odors</subject><subject>Olfactory Perception</subject><subject>Predatory Behavior - drug effects</subject><subject>Predatory Behavior - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0VFrFDEQB_Agij2rn0CQRahP7jnZZJPdx3rYelCpoD6H2WRWt-wlZ7JbuG9vrndYLKLMQ_LwywyTP2MvOSw5CP0OtKhLDVIuecWXuQAesQVvRVsCNPIxW_wWJ-xZSjcAIEHWT9kJ16KSUMsF-_I5ksMpxOLahViuvZstuWIVvBumIfh8vyCMxdrfhvGWUjH9oOI9pjDiRBHHAr0rPpEb8vV8s_vucMTn7EmPY6IXx_OUfbv48HX1sby6vlyvzq9KlE09lcq6xklQ4CzlfXoLvet7Z3WFEoXqtbRtp_raKVV3mnQFnCpBxNuualwD4pS9OfTdxvBzpjSZzZAsjSN6CnMyGiqu20r9F_JW1zp_X4avH8CbMEeflzCKS6mUBv4vVIFomkYLnZE4IBtDSpF6s43DBuPOcDD7-Mw-HLMPx-T4TK67-a-OreduQ-7-zTGvDM6OAJPFsY_o7ZDuXVNL3bR79_bgcItmm3YW4zTYkZKdYyQ_mc7TH3PP_s4fuF9_27y8</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Takahashi, Lorey K</creator><creator>Hubbard, David T</creator><creator>Lee, Iris</creator><creator>Dar, Yasmin</creator><creator>Sipes, Sara M</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Predator Odor-Induced Conditioned Fear Involves the Basolateral and Medial Amygdala</title><author>Takahashi, Lorey K ; Hubbard, David T ; Lee, Iris ; Dar, Yasmin ; Sipes, Sara M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a485t-6cd8d4060dce037fc0fdffdc72a4a36f74c9b6f5d665b7e7201e23ee19b28d803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Amygdala</topic><topic>Amygdala - anatomy & histology</topic><topic>Amygdala - drug effects</topic><topic>Amygdala - injuries</topic><topic>Amygdala - physiology</topic><topic>Animal</topic><topic>Animals</topic><topic>Avoidance Learning - physiology</topic><topic>Basolateral Amygdala</topic><topic>Behavior</topic><topic>Behavior, Animal</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Conditioned Fear</topic><topic>Conditioning, Classical - drug effects</topic><topic>Conditioning, Classical - physiology</topic><topic>Fear</topic><topic>Fear & phobias</topic><topic>Freezing Reaction, Cataleptic - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA Agonists - pharmacology</topic><topic>Male</topic><topic>Memory</topic><topic>Muscimol - pharmacology</topic><topic>Neurosciences</topic><topic>Odorants</topic><topic>Odors</topic><topic>Olfactory Perception</topic><topic>Predatory Behavior - drug effects</topic><topic>Predatory Behavior - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Lorey K</creatorcontrib><creatorcontrib>Hubbard, David T</creatorcontrib><creatorcontrib>Lee, Iris</creatorcontrib><creatorcontrib>Dar, Yasmin</creatorcontrib><creatorcontrib>Sipes, Sara M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Lorey K</au><au>Hubbard, David T</au><au>Lee, Iris</au><au>Dar, Yasmin</au><au>Sipes, Sara M</au><au>Disterhoft, John F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predator Odor-Induced Conditioned Fear Involves the Basolateral and Medial Amygdala</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>121</volume><issue>1</issue><spage>100</spage><epage>110</epage><pages>100-110</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>The basolateral (BLA) and medial nucleus (MeA) of the amygdala participate in the modulation of unconditioned fear induced by predator odor. However, the specific role of these amygdalar nuclei in predator odor-induced fear memory is not known. Therefore, fiber-sparing lesions or temporary inactivation of the BLA or MeA were made either prior to or after exposure to cat odor, and conditioned contextual fear behavior was examined the next day. BLA and MeA lesions produced significant reductions in cat odor-induced unconditioned and conditioned fear-related behavior. In addition, temporary pharmacological neural inactivation methods occurring after exposure to cat odor revealed subtle behavioral alterations indicative of a role of the BLA in fear memory consolidation but not memory retrieval. In contrast, the MeA appears to play a specific role in retrieval but not consolidation. Results show that the BLA participates in the conditioned and unconditioned cat odor stimulus association that underlies fear memory, underscore a novel role of the MeA in predator odor contextual conditioning, and demonstrate different roles of the BLA and MeA in modulating consolidation and retrieval of predator odor fear memory.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>17324054</pmid><doi>10.1037/0735-7044.121.1.100</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-7044 |
| ispartof | Behavioral neuroscience, 2007-02, Vol.121 (1), p.100-110 |
| issn | 0735-7044 1939-0084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70217926 |
| source | MEDLINE; EBSCOhost APA PsycARTICLES |
| subjects | Amygdala Amygdala - anatomy & histology Amygdala - drug effects Amygdala - injuries Amygdala - physiology Animal Animals Avoidance Learning - physiology Basolateral Amygdala Behavior Behavior, Animal Behavioral psychophysiology Biological and medical sciences Brain Conditioned Fear Conditioning, Classical - drug effects Conditioning, Classical - physiology Fear Fear & phobias Freezing Reaction, Cataleptic - drug effects Fundamental and applied biological sciences. Psychology GABA Agonists - pharmacology Male Memory Muscimol - pharmacology Neurosciences Odorants Odors Olfactory Perception Predatory Behavior - drug effects Predatory Behavior - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Long-Evans |
| title | Predator Odor-Induced Conditioned Fear Involves the Basolateral and Medial Amygdala |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T04%3A35%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predator%20Odor-Induced%20Conditioned%20Fear%20Involves%20the%20Basolateral%20and%20Medial%20Amygdala&rft.jtitle=Behavioral%20neuroscience&rft.au=Takahashi,%20Lorey%20K&rft.date=2007-02-01&rft.volume=121&rft.issue=1&rft.spage=100&rft.epage=110&rft.pages=100-110&rft.issn=0735-7044&rft.eissn=1939-0084&rft.coden=BENEDJ&rft_id=info:doi/10.1037/0735-7044.121.1.100&rft_dat=%3Cproquest_cross%3E19757100%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=614466701&rft_id=info:pmid/17324054&rfr_iscdi=true |