Characterization of CS-023 (RO4908463), a Novel Parenteral Carbapenem Antibiotic, and Meropenem as Substrates of Human Renal Transporters

To characterize the renal handling of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, and meropenem in humans, we examined their affinities as substrates to human renal transporters. In vitro studies on the uptake of [14C]CS-023 and [14C]meropenem were conducted using HEK293 cells expr...

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Veröffentlicht in:	DRUG METABOLISM AND PHARMACOKINETICS 2007, Vol.22 (1), p.41-47
Hauptverfasser:	Shibayama, Takahiro, Sugiyama, Daisuke, Kamiyama, Emi, Tokui, Taro, Hirota, Takashi, Ikeda, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anti-Bacterial Agents - metabolism Biological Transport, Active carbapenem antibiotics Carbapenems - metabolism Carrier Proteins - metabolism Cationic Amino Acid Transporter 2 - metabolism Cell Line CS-023 (RO4908463) Humans Kidney - metabolism Kinetics meropenem Organic Anion Transport Protein 1 - metabolism organic anion transporters Organic Anion Transporters, Sodium-Independent - metabolism Organic Cation Transporter 1 - metabolism renal tubular secretion Thienamycins - metabolism
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