CSC, an adenosine A(2A) receptor antagonist and MAO B inhibitor, reverses behavior, monoamine neurotransmission, and amino acid alterations in the 6-OHDA-lesioned rats

The present work showed the effects of 8-(-3-chlorostyryl)-caffeine (CSC), an A(2A) receptors antagonist and MAO B inhibitor, on behavior and biochemical alterations in 6-OHDA-lesioned rats. Male Wistar rats (280 g) were injected with CSC (1 and 5 mg/kg, i.p.) alone or combined with l-DOPA (50 mg/kg...

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Veröffentlicht in:	Brain research 2008-01, Vol.1191, p.192-199
Hauptverfasser:	Aguiar, Lissiana M V, Macêdo, Danielle S, Vasconcelos, Silvania M M, Oliveira, Aline A, de Sousa, F Cléa F, Viana, Glauce S B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A2 Receptor Agonists Animals Behavior, Animal - drug effects Biogenic Monoamines - metabolism Caffeine - analogs & derivatives Caffeine - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Hydroxyindoleacetic Acid - metabolism Lipid Peroxidation - drug effects Male Monoamine Oxidase - drug effects Monoamine Oxidase Inhibitors - pharmacology Neostriatum - drug effects Neostriatum - metabolism Neuroprotective Agents - pharmacology Nitrites - metabolism Norepinephrine - metabolism Oxidopamine Parkinson Disease - drug therapy Parkinson Disease - metabolism Rats Rats, Wistar Receptors, Adenosine A2 - metabolism Rotation Serotonin - metabolism
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