B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE

Background During differentiation, B cells receive signals by antigen through the B-cell receptor (BCR) and signals that induce isotype switching. Objective We sought to investigate the effects of BCR ligation on isotype switching. Methods Naive B cells from BALB/c mice were stimulated with LPS plus...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2008, Vol.121 (1), p.191-196.e2
Hauptverfasser:	Jabara, Haifa H., BS, Chaudhuri, Jayanta, PhD, Dutt, Shilpee, PhD, Dedeoglu, Fatma, MD, Weng, Yu, BS, Murphy, Michael M., BS, Franco, Sonia, MD, PhD, Alt, Fredrick W., PhD, Manis, John, MD, Geha, Raif S., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	activation-induced cytidine deaminase Allergy and Immunology Animals B-cell receptor B-Lymphocytes - metabolism Biological and medical sciences Cells, Cultured Cytidine Deaminase - biosynthesis Enzyme Induction Fundamental and applied biological sciences. Psychology Fundamental immunology IgE Immune system Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - immunology Immunoglobulin E - biosynthesis Immunoglobulin G - biosynthesis Immunoglobulins Immunopathology isotype switching Kinases Medical sciences Mice Mice, Inbred BALB C Receptors, Antigen, B-Cell - metabolism Recombination, Genetic Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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