Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation
The electrochemical behavior of glipizide at the hanging mercury drop electrode (HMDE) was studied in B–R universal buffers of pH 1.7–11. The voltammograms exhibited a well-defined 4-electron irreversible cathodic peak which attributed to reduction of the two C N double bonds of the pyrazine ring of...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2007-03, Vol.43 (4), p.1465-1469 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Ghoneim, E.M. El-Attar, M.A. Hammam, E. Khashaba, P.Y. |
| description | The electrochemical behavior of glipizide at the hanging mercury drop electrode (HMDE) was studied in B–R universal buffers of pH 1.7–11. The voltammograms exhibited a well-defined 4-electron irreversible cathodic peak which attributed to reduction of the two C
N double bonds of the pyrazine ring of glipizide molecule. Glipizide was found to has an interfacial adsorptive character onto the mercury electrode surface. A monolayer surface coverage of 1.02
×
10
−10
mol
cm
−2 was estimated and hence each adsorbed glipizide molecule occupied an area of 1.63
nm
2 onto the mercury electrode surface. A simple and precise square-wave adsorptive cathodic stripping (SWAdCS) voltammetric procedure was described for quantification of bulk glipizide with a limit of detection of 1.5
×
10
−10
M and a limit of quantitation of 5
×
10
−10
M. The proposed procedure was successfully applied for quantitation of glipizide in its pharmaceutical formulation (Minidiab tablets) without interference from excipients. |
| doi_str_mv | 10.1016/j.jpba.2006.09.025 |
| format | Article |
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N double bonds of the pyrazine ring of glipizide molecule. Glipizide was found to has an interfacial adsorptive character onto the mercury electrode surface. A monolayer surface coverage of 1.02
×
10
−10
mol
cm
−2 was estimated and hence each adsorbed glipizide molecule occupied an area of 1.63
nm
2 onto the mercury electrode surface. A simple and precise square-wave adsorptive cathodic stripping (SWAdCS) voltammetric procedure was described for quantification of bulk glipizide with a limit of detection of 1.5
×
10
−10
M and a limit of quantitation of 5
×
10
−10
M. The proposed procedure was successfully applied for quantitation of glipizide in its pharmaceutical formulation (Minidiab tablets) without interference from excipients.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2006.09.025</identifier><identifier>PMID: 17045771</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Buffers ; Cyclic voltammetry ; Electrochemistry - methods ; Electrodes ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Glipizide ; Glipizide - blood ; Glipizide - chemistry ; Humans ; Hydrogen-Ion Concentration ; Hypoglycemic Agents - blood ; Hypoglycemic Agents - chemistry ; Medical sciences ; Minidiab tablets ; Molecular Structure ; Pharmaceutical Preparations - analysis ; Pharmaceutical Preparations - blood ; Pharmaceutical Preparations - chemistry ; Pharmacology. Drug treatments ; Quantification ; Reproducibility of Results ; Sensitivity and Specificity ; Square-wave adsorptive stripping voltammetry ; Tablets</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2007-03, Vol.43 (4), p.1465-1469</ispartof><rights>2006 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-694fa11d4e5a1696571c10f4175dc597634220563fd2bb2fb85cd6529d62cd863</citedby><cites>FETCH-LOGICAL-c384t-694fa11d4e5a1696571c10f4175dc597634220563fd2bb2fb85cd6529d62cd863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0731708506006546$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18583257$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17045771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghoneim, E.M.</creatorcontrib><creatorcontrib>El-Attar, M.A.</creatorcontrib><creatorcontrib>Hammam, E.</creatorcontrib><creatorcontrib>Khashaba, P.Y.</creatorcontrib><title>Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>The electrochemical behavior of glipizide at the hanging mercury drop electrode (HMDE) was studied in B–R universal buffers of pH 1.7–11. The voltammograms exhibited a well-defined 4-electron irreversible cathodic peak which attributed to reduction of the two C
N double bonds of the pyrazine ring of glipizide molecule. Glipizide was found to has an interfacial adsorptive character onto the mercury electrode surface. A monolayer surface coverage of 1.02
×
10
−10
mol
cm
−2 was estimated and hence each adsorbed glipizide molecule occupied an area of 1.63
nm
2 onto the mercury electrode surface. A simple and precise square-wave adsorptive cathodic stripping (SWAdCS) voltammetric procedure was described for quantification of bulk glipizide with a limit of detection of 1.5
×
10
−10
M and a limit of quantitation of 5
×
10
−10
M. The proposed procedure was successfully applied for quantitation of glipizide in its pharmaceutical formulation (Minidiab tablets) without interference from excipients.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Buffers</subject><subject>Cyclic voltammetry</subject><subject>Electrochemistry - methods</subject><subject>Electrodes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Glipizide</subject><subject>Glipizide - blood</subject><subject>Glipizide - chemistry</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypoglycemic Agents - blood</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Medical sciences</subject><subject>Minidiab tablets</subject><subject>Molecular Structure</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceutical Preparations - blood</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmacology. Drug treatments</subject><subject>Quantification</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Square-wave adsorptive stripping voltammetry</subject><subject>Tablets</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlqHDEURUVIiNtOfiCLoE28q8qTqiRVgTfGeAJDFkkgO6HS0FanJmswJF8ftbvBu6weXM69PA5CnwjUBAj_uqt366BqCsBr6Gug7A3akE40FeXtr7doA6IhlYCOnaDTGHcAwEjfvkcnREDLhCAblL-n4NfVz1v8vIxJTZMtgcZPWc3JO69V8suMF4fTo8X7rDJeDTYVxoS8xdvRr_6vNxb7GQ95_I3dEqZCGrw-qjApbXOB1fiS5_Fl7wN659QY7cfjPUM_b65_XN1VD99u768uHyrddG2qeN86RYhpLVOE95wJogm4lghmNOsFb1pKgfHGGToM1A0d04Yz2htOtel4c4bOD7trWJ6yjUlOPmo7jmq2S45SACWsDBeQHkAdlhiDdXINflLhjyQg97LlTu5ly71sCb0sskvp83E9D5M1r5Wj3QJ8OQIqFgMuqFn7-Mp1rGsoE4W7OHC2uHj2NsiovZ21NT5YnaRZ_P_--AcECZ9O</recordid><startdate>20070312</startdate><enddate>20070312</enddate><creator>Ghoneim, E.M.</creator><creator>El-Attar, M.A.</creator><creator>Hammam, E.</creator><creator>Khashaba, P.Y.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070312</creationdate><title>Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation</title><author>Ghoneim, E.M. ; El-Attar, M.A. ; Hammam, E. ; Khashaba, P.Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-694fa11d4e5a1696571c10f4175dc597634220563fd2bb2fb85cd6529d62cd863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Buffers</topic><topic>Cyclic voltammetry</topic><topic>Electrochemistry - methods</topic><topic>Electrodes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Glipizide</topic><topic>Glipizide - blood</topic><topic>Glipizide - chemistry</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypoglycemic Agents - blood</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>Medical sciences</topic><topic>Minidiab tablets</topic><topic>Molecular Structure</topic><topic>Pharmaceutical Preparations - analysis</topic><topic>Pharmaceutical Preparations - blood</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmacology. Drug treatments</topic><topic>Quantification</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Square-wave adsorptive stripping voltammetry</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghoneim, E.M.</creatorcontrib><creatorcontrib>El-Attar, M.A.</creatorcontrib><creatorcontrib>Hammam, E.</creatorcontrib><creatorcontrib>Khashaba, P.Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghoneim, E.M.</au><au>El-Attar, M.A.</au><au>Hammam, E.</au><au>Khashaba, P.Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2007-03-12</date><risdate>2007</risdate><volume>43</volume><issue>4</issue><spage>1465</spage><epage>1469</epage><pages>1465-1469</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>The electrochemical behavior of glipizide at the hanging mercury drop electrode (HMDE) was studied in B–R universal buffers of pH 1.7–11. The voltammograms exhibited a well-defined 4-electron irreversible cathodic peak which attributed to reduction of the two C
N double bonds of the pyrazine ring of glipizide molecule. Glipizide was found to has an interfacial adsorptive character onto the mercury electrode surface. A monolayer surface coverage of 1.02
×
10
−10
mol
cm
−2 was estimated and hence each adsorbed glipizide molecule occupied an area of 1.63
nm
2 onto the mercury electrode surface. A simple and precise square-wave adsorptive cathodic stripping (SWAdCS) voltammetric procedure was described for quantification of bulk glipizide with a limit of detection of 1.5
×
10
−10
M and a limit of quantitation of 5
×
10
−10
M. The proposed procedure was successfully applied for quantitation of glipizide in its pharmaceutical formulation (Minidiab tablets) without interference from excipients.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17045771</pmid><doi>10.1016/j.jpba.2006.09.025</doi><tpages>5</tpages></addata></record> |
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| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Buffers Cyclic voltammetry Electrochemistry - methods Electrodes Fundamental and applied biological sciences. Psychology General pharmacology Glipizide Glipizide - blood Glipizide - chemistry Humans Hydrogen-Ion Concentration Hypoglycemic Agents - blood Hypoglycemic Agents - chemistry Medical sciences Minidiab tablets Molecular Structure Pharmaceutical Preparations - analysis Pharmaceutical Preparations - blood Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Quantification Reproducibility of Results Sensitivity and Specificity Square-wave adsorptive stripping voltammetry Tablets |
| title | Stripping voltammetric quantification of the anti-diabetic drug glipizide in bulk form and pharmaceutical formulation |
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