Closure of the Pleural Dead Space After Pneumonectomy in a Rabbit Model: Use of Bioabsorbable Lactic Acid and Caprolactone Copolymer Cubes
The remaining pleural dead space after pulmonary resection sometimes causes serious complications, such as empyema. The objective of this study was induction of granulation tissue in uninfected pleural space after pneumonectomy in a rabbit model using implantation of bioabsorbable and porous poly-l-...
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| Veröffentlicht in: | ASAIO journal (1992) 2008-01, Vol.54 (1), p.109-114 |
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| container_title | ASAIO journal (1992) |
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| creator | Chang, Sung Soo Igai, Hitoshi Misaki, Noriyuki Gotoh, Masashi Yamamoto, Yasumichi Tabata, Yasuhiko Yokomise, Hiroyasu |
| description | The remaining pleural dead space after pulmonary resection sometimes causes serious complications, such as empyema. The objective of this study was induction of granulation tissue in uninfected pleural space after pneumonectomy in a rabbit model using implantation of bioabsorbable and porous poly-l-lactic acid and -caprolactone copolymer (PLAC) cubes. Twelve Japanese white rabbits were randomly spilt into two groupsthe control group (n = 6) underwent simple left pneumonectomy, whereas the experimental group (n = 6) underwent left pneumonectomy followed by filling of the left hemithorax with PLAC cubes. One rabbit in each group was killed at 1, 2, 3, and 6 months after surgery, and pleural tissue was evaluated. In the experimental group, granulation tissue inside the PLAC cubes had begun to form at 1 month after implantation. From 3 months to 6 months, proliferated granulation tissue occupied the left postpneumonectomy pleural space with no residual space. The implanted PLAC material was being gradually degraded. We were able to induce self-assembled granulation tissue in the pleural space after pneumonectomy in a rabbit model using bioabsorbable PLAC cubes. The use of this technique allowed the residual pleural space to be closed after pulmonary resection. |
| doi_str_mv | 10.1097/MAT.0b013e318160cffa |
| format | Article |
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The objective of this study was induction of granulation tissue in uninfected pleural space after pneumonectomy in a rabbit model using implantation of bioabsorbable and porous poly-l-lactic acid and -caprolactone copolymer (PLAC) cubes. Twelve Japanese white rabbits were randomly spilt into two groupsthe control group (n = 6) underwent simple left pneumonectomy, whereas the experimental group (n = 6) underwent left pneumonectomy followed by filling of the left hemithorax with PLAC cubes. One rabbit in each group was killed at 1, 2, 3, and 6 months after surgery, and pleural tissue was evaluated. In the experimental group, granulation tissue inside the PLAC cubes had begun to form at 1 month after implantation. From 3 months to 6 months, proliferated granulation tissue occupied the left postpneumonectomy pleural space with no residual space. The implanted PLAC material was being gradually degraded. We were able to induce self-assembled granulation tissue in the pleural space after pneumonectomy in a rabbit model using bioabsorbable PLAC cubes. The use of this technique allowed the residual pleural space to be closed after pulmonary resection.</description><identifier>ISSN: 1058-2916</identifier><identifier>EISSN: 1538-943X</identifier><identifier>DOI: 10.1097/MAT.0b013e318160cffa</identifier><identifier>PMID: 18204325</identifier><language>eng</language><publisher>United States: Amercian Society of Artificial Internal Organs</publisher><subject>Absorbable Implants ; Animals ; Biocompatible Materials - therapeutic use ; Caproates - therapeutic use ; Cell Proliferation ; Empyema, Pleural - etiology ; Lactic Acid - therapeutic use ; Lactones - therapeutic use ; Lung - surgery ; Male ; Pleural Diseases - therapy ; Polyesters ; Polymers - chemistry ; Polymers - therapeutic use ; Rabbits ; Random Allocation ; Time Factors ; Treatment Outcome</subject><ispartof>ASAIO journal (1992), 2008-01, Vol.54 (1), p.109-114</ispartof><rights>2008Amercian Society of Artificial Internal Organs</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5069-7f0cc353af4dfd00da5d5800b955f73d25864a5943a8222367360e694b7e6a6f3</citedby><cites>FETCH-LOGICAL-c5069-7f0cc353af4dfd00da5d5800b955f73d25864a5943a8222367360e694b7e6a6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00002480-200801000-00019$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,778,782,4597,27913,27914,65220</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18204325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Sung Soo</creatorcontrib><creatorcontrib>Igai, Hitoshi</creatorcontrib><creatorcontrib>Misaki, Noriyuki</creatorcontrib><creatorcontrib>Gotoh, Masashi</creatorcontrib><creatorcontrib>Yamamoto, Yasumichi</creatorcontrib><creatorcontrib>Tabata, Yasuhiko</creatorcontrib><creatorcontrib>Yokomise, Hiroyasu</creatorcontrib><title>Closure of the Pleural Dead Space After Pneumonectomy in a Rabbit Model: Use of Bioabsorbable Lactic Acid and Caprolactone Copolymer Cubes</title><title>ASAIO journal (1992)</title><addtitle>ASAIO J</addtitle><description>The remaining pleural dead space after pulmonary resection sometimes causes serious complications, such as empyema. The objective of this study was induction of granulation tissue in uninfected pleural space after pneumonectomy in a rabbit model using implantation of bioabsorbable and porous poly-l-lactic acid and -caprolactone copolymer (PLAC) cubes. Twelve Japanese white rabbits were randomly spilt into two groupsthe control group (n = 6) underwent simple left pneumonectomy, whereas the experimental group (n = 6) underwent left pneumonectomy followed by filling of the left hemithorax with PLAC cubes. One rabbit in each group was killed at 1, 2, 3, and 6 months after surgery, and pleural tissue was evaluated. In the experimental group, granulation tissue inside the PLAC cubes had begun to form at 1 month after implantation. From 3 months to 6 months, proliferated granulation tissue occupied the left postpneumonectomy pleural space with no residual space. The implanted PLAC material was being gradually degraded. We were able to induce self-assembled granulation tissue in the pleural space after pneumonectomy in a rabbit model using bioabsorbable PLAC cubes. The use of this technique allowed the residual pleural space to be closed after pulmonary resection.</description><subject>Absorbable Implants</subject><subject>Animals</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Caproates - therapeutic use</subject><subject>Cell Proliferation</subject><subject>Empyema, Pleural - etiology</subject><subject>Lactic Acid - therapeutic use</subject><subject>Lactones - therapeutic use</subject><subject>Lung - surgery</subject><subject>Male</subject><subject>Pleural Diseases - therapy</subject><subject>Polyesters</subject><subject>Polymers - chemistry</subject><subject>Polymers - therapeutic use</subject><subject>Rabbits</subject><subject>Random Allocation</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1058-2916</issn><issn>1538-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd-K1TAQxoso7h99A5Fcedd1kjRt6t2x6iqcxUV3wbsySSecatqcTVqW8wo-tdE9sODAMJlk5kf4vqJ4xeGCQ9u8vdrcXIABLklyzWuwzuGT4pQrqcu2kj-e5jMoXYqW1yfFWUo_AfKj5M-LE64FVFKo0-J350NaI7Hg2LIjdu1pjejZB8KBfd-jJbZxC0V2PdM6hZnsEqYDG2eG7BsaMy7sKgzk37Hb9A_yfgxoUogGjSe2RbuMlm3sODCcB9bhPgafLzOJdWEf_GHK8G41lF4Uzxz6RC-P9by4_fTxpvtcbr9efuk229IqqNuycWCtVBJdNbgBYEA1KA1gWqVcIwehdF2hyhKgFkLIupE1UN1WpqEaayfPizcP3PyVu5XS0k9jsuQ9zhTW1DcguFJa5MHqYdDGkFIk1-_jOGE89Bz6vx702YP-fw_y2usjfzUTDY9LR9EfuffBZ2nTL7_eU-x3hH7Z9ZBDVBpKAaCB567MyVv5B31Qk3k</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Chang, Sung Soo</creator><creator>Igai, Hitoshi</creator><creator>Misaki, Noriyuki</creator><creator>Gotoh, Masashi</creator><creator>Yamamoto, Yasumichi</creator><creator>Tabata, Yasuhiko</creator><creator>Yokomise, Hiroyasu</creator><general>Amercian Society of Artificial Internal Organs</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Closure of the Pleural Dead Space After Pneumonectomy in a Rabbit Model: Use of Bioabsorbable Lactic Acid and Caprolactone Copolymer Cubes</title><author>Chang, Sung Soo ; Igai, Hitoshi ; Misaki, Noriyuki ; Gotoh, Masashi ; Yamamoto, Yasumichi ; Tabata, Yasuhiko ; Yokomise, Hiroyasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5069-7f0cc353af4dfd00da5d5800b955f73d25864a5943a8222367360e694b7e6a6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Absorbable Implants</topic><topic>Animals</topic><topic>Biocompatible Materials - therapeutic use</topic><topic>Caproates - therapeutic use</topic><topic>Cell Proliferation</topic><topic>Empyema, Pleural - etiology</topic><topic>Lactic Acid - therapeutic use</topic><topic>Lactones - therapeutic use</topic><topic>Lung - surgery</topic><topic>Male</topic><topic>Pleural Diseases - therapy</topic><topic>Polyesters</topic><topic>Polymers - chemistry</topic><topic>Polymers - therapeutic use</topic><topic>Rabbits</topic><topic>Random Allocation</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Sung Soo</creatorcontrib><creatorcontrib>Igai, Hitoshi</creatorcontrib><creatorcontrib>Misaki, Noriyuki</creatorcontrib><creatorcontrib>Gotoh, Masashi</creatorcontrib><creatorcontrib>Yamamoto, Yasumichi</creatorcontrib><creatorcontrib>Tabata, Yasuhiko</creatorcontrib><creatorcontrib>Yokomise, Hiroyasu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ASAIO journal (1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Sung Soo</au><au>Igai, Hitoshi</au><au>Misaki, Noriyuki</au><au>Gotoh, Masashi</au><au>Yamamoto, Yasumichi</au><au>Tabata, Yasuhiko</au><au>Yokomise, Hiroyasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Closure of the Pleural Dead Space After Pneumonectomy in a Rabbit Model: Use of Bioabsorbable Lactic Acid and Caprolactone Copolymer Cubes</atitle><jtitle>ASAIO journal (1992)</jtitle><addtitle>ASAIO J</addtitle><date>2008-01</date><risdate>2008</risdate><volume>54</volume><issue>1</issue><spage>109</spage><epage>114</epage><pages>109-114</pages><issn>1058-2916</issn><eissn>1538-943X</eissn><abstract>The remaining pleural dead space after pulmonary resection sometimes causes serious complications, such as empyema. The objective of this study was induction of granulation tissue in uninfected pleural space after pneumonectomy in a rabbit model using implantation of bioabsorbable and porous poly-l-lactic acid and -caprolactone copolymer (PLAC) cubes. Twelve Japanese white rabbits were randomly spilt into two groupsthe control group (n = 6) underwent simple left pneumonectomy, whereas the experimental group (n = 6) underwent left pneumonectomy followed by filling of the left hemithorax with PLAC cubes. One rabbit in each group was killed at 1, 2, 3, and 6 months after surgery, and pleural tissue was evaluated. In the experimental group, granulation tissue inside the PLAC cubes had begun to form at 1 month after implantation. From 3 months to 6 months, proliferated granulation tissue occupied the left postpneumonectomy pleural space with no residual space. The implanted PLAC material was being gradually degraded. 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| subjects | Absorbable Implants Animals Biocompatible Materials - therapeutic use Caproates - therapeutic use Cell Proliferation Empyema, Pleural - etiology Lactic Acid - therapeutic use Lactones - therapeutic use Lung - surgery Male Pleural Diseases - therapy Polyesters Polymers - chemistry Polymers - therapeutic use Rabbits Random Allocation Time Factors Treatment Outcome |
| title | Closure of the Pleural Dead Space After Pneumonectomy in a Rabbit Model: Use of Bioabsorbable Lactic Acid and Caprolactone Copolymer Cubes |
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