Study of synthetic peptides derived from the PKI55 protein, a protein kinase C modulator, in human neutrophils stimulated by the methyl ester derivative of the hydrophobic N-formyl tripeptide for-Met-Leu-Phe-OH

Elucidation of the involvement of protein kinase C subtypes in several diseases is an important challenge for the future development of new drug targets. We previously identified the PKI55 protein, which acts as a protein kinase C modulator, establishing a feedback loop of inhibition. The PKI55 prot...

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Veröffentlicht in:	The FEBS journal 2008-02, Vol.275 (3), p.449-457
Hauptverfasser:	Selvatici, Rita, Falzarano, Sofia, Franceschetti, Lara, Mollica, Adriano, Guerrini, Remo, Siniscalchi, Anna, Spisani, Susanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biochemistry Blotting, Western Brain Brain - drug effects Brain - metabolism Cell Survival - drug effects Cellular biology chemotaxis Enzyme Activation - drug effects human neutrophils Humans Hydrophobic and Hydrophilic Interactions Inhibitor drugs Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism lysozyme Membranes Molecular Sequence Data Muramidase - metabolism N-Formylmethionine Leucyl-Phenylalanine - chemistry N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology PKC PKI55 Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Kinase C beta Proteins Proteins - chemistry Rats Rodents Superoxides - metabolism
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