Lithium affects REM sleep occurrence, autonomic activity and brain second messengers in the rat
The effects of a single intraperitoneal administration of lithium, a drug used to prevent the recurrence of mania in bipolar disorders, were determined in the rat by studying changes in: (i) the wake–sleep cycle; (ii) autonomic parameters (hypothalamic and tail temperature, heart rate); (iii) the ca...
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| Veröffentlicht in: | Behavioural brain research 2008-03, Vol.187 (2), p.254-261 |
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| creator | Jones, Christine Ann Perez, Emanuele Amici, Roberto Luppi, Marco Baracchi, Francesca Cerri, Matteo Dentico, Daniela Zamboni, Giovanni |
| description | The effects of a single intraperitoneal administration of lithium, a drug used to prevent the recurrence of mania in bipolar disorders, were determined in the rat by studying changes in: (i) the wake–sleep cycle; (ii) autonomic parameters (hypothalamic and tail temperature, heart rate); (iii) the capacity to accumulate cAMP and IP
3 in the preoptic-anterior hypothalamic region (PO-AH) and in the cerebral cortex (CC) under an hypoxic stimulation at normal laboratory and at low ambient temperature (
T
a). In the immediate hours following the injection, lithium induced: (i) a significant reduction in REM sleep; (ii) a non-significant reduction in the delta power density of the EEG in NREM sleep; (iii) a significant decrease in the concentration of cAMP in PO-AH at normal laboratory
T
a; (iv) a significant increase of IP
3 concentration in CC following exposure to low
T
a. The earliest and most sensitive effects of lithium appear to be those concerning sleep. These changes are concomitant with biochemical effects that, in spite of a systemic administration of the substance, may be differentiated according to the second messenger involved, the brain region and the ambient condition. |
| doi_str_mv | 10.1016/j.bbr.2007.09.017 |
| format | Article |
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3 in the preoptic-anterior hypothalamic region (PO-AH) and in the cerebral cortex (CC) under an hypoxic stimulation at normal laboratory and at low ambient temperature (
T
a). In the immediate hours following the injection, lithium induced: (i) a significant reduction in REM sleep; (ii) a non-significant reduction in the delta power density of the EEG in NREM sleep; (iii) a significant decrease in the concentration of cAMP in PO-AH at normal laboratory
T
a; (iv) a significant increase of IP
3 concentration in CC following exposure to low
T
a. The earliest and most sensitive effects of lithium appear to be those concerning sleep. These changes are concomitant with biochemical effects that, in spite of a systemic administration of the substance, may be differentiated according to the second messenger involved, the brain region and the ambient condition.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2007.09.017</identifier><identifier>PMID: 17964671</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Analysis of Variance ; Animals ; Antimanic Agents - pharmacology ; Autonomic activity ; Autonomic Nervous System - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Body Temperature Regulation - drug effects ; Brain - drug effects ; Brain - metabolism ; cAMP ; Cerebral cortex ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; Cyclic AMP - metabolism ; Electroencephalography - drug effects ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; Hypothalamus - drug effects ; Hypoxia ; Inositol 1,4,5-Trisphosphate - metabolism ; IP 3 ; Lithium Chloride - pharmacology ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Preoptic anterior-hypothalamic area ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopharmacology ; Rats ; Rats, Sprague-Dawley ; REM sleep ; Second Messenger Systems - drug effects ; Sleep, REM - drug effects ; Statistics, Nonparametric</subject><ispartof>Behavioural brain research, 2008-03, Vol.187 (2), p.254-261</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-9fc96fa1cec3a43efc44545000602217bc65d82ce3d10512bc4c58068bcbb88e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2007.09.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20040383$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17964671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, Christine Ann</creatorcontrib><creatorcontrib>Perez, Emanuele</creatorcontrib><creatorcontrib>Amici, Roberto</creatorcontrib><creatorcontrib>Luppi, Marco</creatorcontrib><creatorcontrib>Baracchi, Francesca</creatorcontrib><creatorcontrib>Cerri, Matteo</creatorcontrib><creatorcontrib>Dentico, Daniela</creatorcontrib><creatorcontrib>Zamboni, Giovanni</creatorcontrib><title>Lithium affects REM sleep occurrence, autonomic activity and brain second messengers in the rat</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>The effects of a single intraperitoneal administration of lithium, a drug used to prevent the recurrence of mania in bipolar disorders, were determined in the rat by studying changes in: (i) the wake–sleep cycle; (ii) autonomic parameters (hypothalamic and tail temperature, heart rate); (iii) the capacity to accumulate cAMP and IP
3 in the preoptic-anterior hypothalamic region (PO-AH) and in the cerebral cortex (CC) under an hypoxic stimulation at normal laboratory and at low ambient temperature (
T
a). In the immediate hours following the injection, lithium induced: (i) a significant reduction in REM sleep; (ii) a non-significant reduction in the delta power density of the EEG in NREM sleep; (iii) a significant decrease in the concentration of cAMP in PO-AH at normal laboratory
T
a; (iv) a significant increase of IP
3 concentration in CC following exposure to low
T
a. The earliest and most sensitive effects of lithium appear to be those concerning sleep. These changes are concomitant with biochemical effects that, in spite of a systemic administration of the substance, may be differentiated according to the second messenger involved, the brain region and the ambient condition.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Antimanic Agents - pharmacology</subject><subject>Autonomic activity</subject><subject>Autonomic Nervous System - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Body Temperature Regulation - drug effects</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>cAMP</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cyclic AMP - metabolism</subject><subject>Electroencephalography - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>Hypothalamus - drug effects</subject><subject>Hypoxia</subject><subject>Inositol 1,4,5-Trisphosphate - metabolism</subject><subject>IP 3</subject><subject>Lithium Chloride - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Preoptic anterior-hypothalamic area</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>REM sleep</subject><subject>Second Messenger Systems - drug effects</subject><subject>Sleep, REM - drug effects</subject><subject>Statistics, Nonparametric</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVoaTZJf0AuQZfmVLv6si2TUwhpGthSKM1ZSONxo8UfG0kO5N9Hyy7NrTkNGp4ZRs9LyDlnJWe8_rYpnQulYKwpWVsy3hyRFdeNKJpKtR_IKjN1oaTQx-Qkxg1jTLGKfyLHvGlrVTd8Rczap0e_jNT2PUKK9PftTxoHxC2dAZYQcAL8Su2S5mkePVALyT_79ELt1FEXrJ9oRJjzY8QYcfqLIdLcTI9Ig01n5GNvh4ifD_WUPHy__XPzo1j_uru_uV4XoLhIRdtDW_eWA4K0SmIPSlWqyhfXTAjeOKirTgtA2fH8BeFAQaVZrR04pzXKU3K537sN89OCMZnRR8BhsBPOSzQNE1xyqd4FBaukbnWbQb4HIcwxBuzNNvjRhhfDmdnpNxuT9ZudfsNak_XnmYvD8sWN2L1NHHxn4MsBsBHs0Ac7gY__OLFLSGqZuas9h9nZs8dgIvhdFJ0POSbTzf4_Z7wCS6miZw</recordid><startdate>20080305</startdate><enddate>20080305</enddate><creator>Jones, Christine Ann</creator><creator>Perez, Emanuele</creator><creator>Amici, Roberto</creator><creator>Luppi, Marco</creator><creator>Baracchi, Francesca</creator><creator>Cerri, Matteo</creator><creator>Dentico, Daniela</creator><creator>Zamboni, Giovanni</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080305</creationdate><title>Lithium affects REM sleep occurrence, autonomic activity and brain second messengers in the rat</title><author>Jones, Christine Ann ; Perez, Emanuele ; Amici, Roberto ; Luppi, Marco ; Baracchi, Francesca ; Cerri, Matteo ; Dentico, Daniela ; Zamboni, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-9fc96fa1cec3a43efc44545000602217bc65d82ce3d10512bc4c58068bcbb88e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Antimanic Agents - pharmacology</topic><topic>Autonomic activity</topic><topic>Autonomic Nervous System - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Body Temperature Regulation - drug effects</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>cAMP</topic><topic>Cerebral cortex</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cyclic AMP - metabolism</topic><topic>Electroencephalography - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>Hypothalamus - drug effects</topic><topic>Hypoxia</topic><topic>Inositol 1,4,5-Trisphosphate - metabolism</topic><topic>IP 3</topic><topic>Lithium Chloride - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Preoptic anterior-hypothalamic area</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>REM sleep</topic><topic>Second Messenger Systems - drug effects</topic><topic>Sleep, REM - drug effects</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Christine Ann</creatorcontrib><creatorcontrib>Perez, Emanuele</creatorcontrib><creatorcontrib>Amici, Roberto</creatorcontrib><creatorcontrib>Luppi, Marco</creatorcontrib><creatorcontrib>Baracchi, Francesca</creatorcontrib><creatorcontrib>Cerri, Matteo</creatorcontrib><creatorcontrib>Dentico, Daniela</creatorcontrib><creatorcontrib>Zamboni, Giovanni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Christine Ann</au><au>Perez, Emanuele</au><au>Amici, Roberto</au><au>Luppi, Marco</au><au>Baracchi, Francesca</au><au>Cerri, Matteo</au><au>Dentico, Daniela</au><au>Zamboni, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lithium affects REM sleep occurrence, autonomic activity and brain second messengers in the rat</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2008-03-05</date><risdate>2008</risdate><volume>187</volume><issue>2</issue><spage>254</spage><epage>261</epage><pages>254-261</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>The effects of a single intraperitoneal administration of lithium, a drug used to prevent the recurrence of mania in bipolar disorders, were determined in the rat by studying changes in: (i) the wake–sleep cycle; (ii) autonomic parameters (hypothalamic and tail temperature, heart rate); (iii) the capacity to accumulate cAMP and IP
3 in the preoptic-anterior hypothalamic region (PO-AH) and in the cerebral cortex (CC) under an hypoxic stimulation at normal laboratory and at low ambient temperature (
T
a). In the immediate hours following the injection, lithium induced: (i) a significant reduction in REM sleep; (ii) a non-significant reduction in the delta power density of the EEG in NREM sleep; (iii) a significant decrease in the concentration of cAMP in PO-AH at normal laboratory
T
a; (iv) a significant increase of IP
3 concentration in CC following exposure to low
T
a. The earliest and most sensitive effects of lithium appear to be those concerning sleep. These changes are concomitant with biochemical effects that, in spite of a systemic administration of the substance, may be differentiated according to the second messenger involved, the brain region and the ambient condition.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>17964671</pmid><doi>10.1016/j.bbr.2007.09.017</doi><tpages>8</tpages></addata></record> |
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| ispartof | Behavioural brain research, 2008-03, Vol.187 (2), p.254-261 |
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| subjects | Analysis of Variance Animals Antimanic Agents - pharmacology Autonomic activity Autonomic Nervous System - drug effects Behavioral psychophysiology Biological and medical sciences Body Temperature Regulation - drug effects Brain - drug effects Brain - metabolism cAMP Cerebral cortex Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cyclic AMP - metabolism Electroencephalography - drug effects Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Hypothalamus - drug effects Hypoxia Inositol 1,4,5-Trisphosphate - metabolism IP 3 Lithium Chloride - pharmacology Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Preoptic anterior-hypothalamic area Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopharmacology Rats Rats, Sprague-Dawley REM sleep Second Messenger Systems - drug effects Sleep, REM - drug effects Statistics, Nonparametric |
| title | Lithium affects REM sleep occurrence, autonomic activity and brain second messengers in the rat |
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