effects of local perfusion of DAMGO on extracellular GABA and glutamate concentrations in the rostral ventromedial medulla

Electrophysiological data suggest an involvement of rostral ventromedial medulla (RVM) GABA and glutamate (GLU) neurons in morphine analgesia. Direct evidence that extracellular concentrations of GABA or GLU are altered in response to mu opioid receptor (MOP-R) activation is, however, lacking. We us...

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Veröffentlicht in:	Journal of neurochemistry 2008-02, Vol.104 (3), p.806-817
Hauptverfasser:	Schepers, Raf Jan-Filip, Mahoney, Janet Lynn, Zapata, Agustin, Chefer, Vladimir, Shippenberg, Toni Shaun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenals. Interrenals Adrenomedullary hormones. Regulation analgesia Analgesics, Opioid - pharmacology Animals Area Under Curve Behavior, Animal Biochemistry Biological and medical sciences Brain Cellular biology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dicarboxylic Acids - pharmacology Dose-Response Relationship, Drug Enkephalin, Ala-MePhe-Gly- - pharmacology Extracellular Fluid - drug effects Fundamental and applied biological sciences. Psychology GABA gamma-Aminobutyric Acid - metabolism glutamate Glutamic Acid - metabolism Hyperalgesia - physiopathology Male Medulla Oblongata - drug effects microdialysis Microdialysis - methods Narcotic Antagonists - pharmacology Neurology Neurotransmitter Uptake Inhibitors - pharmacology Neurotransmitters Peptides - pharmacology Potassium Chloride - pharmacology Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Reaction Time - drug effects rostral ventromedial medulla Vertebrates: endocrinology Vertebrates: nervous system and sense organs
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