Preventative ibandronate treatment has the most beneficial effect on the microstructure of bone in experimental tumor osteolysis
We investigated the effect of ibandronate on three-dimensional (3-D) microstructure and bone mass in experimentally induced tumor osteolysis. Walker carcinosarcoma cells were implanted into the left femur of female rats that received 26-day ibandronate pretreatment followed by continued therapy or i...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2007-03, Vol.25 (2), p.86-92 |
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| creator | KURTH, Andreas A KIM, Soo-Zin SHEA, Marie BAUSS, Frieder HAYES, Wilson C MÜLLER, Ralph |
| description | We investigated the effect of ibandronate on three-dimensional (3-D) microstructure and bone mass in experimentally induced tumor osteolysis. Walker carcinosarcoma cells were implanted into the left femur of female rats that received 26-day ibandronate pretreatment followed by continued therapy or ibandronate posttreatment only. A tumor-only group received isotonic saline. At endpoint, excised femurs were scanned using microcomputed tomography (microCT) to assess bone volume density, bone mineral content, trabecular number/thickness, and separation for cortical plus trabecular bone or trabecular bone alone. Compared with the nonimplanted right femur, bone volume and surface density and trabecular number and thickness were reduced in the distal left femur following tumor cell implantation. microCT analysis revealed greater cortical and trabecular bone mineral content in the preventative and interventional (pre-post tumor) ibandronate group, and the interventional (post-tumor) ibandronate group, versus the tumor-only group. Bone volume density was significantly higher in pre-post and post-tumor groups compared to the tumor-only group. After preventative and interventional ibandronate, bone volume density and trabecular thickness were 13% and 60% greater, respectively, than in the post-tumor treatment group. 3-D microCT images confirmed microstructural changes. We conclude that combined interventional and preventative ibandronate preserves bone strength and integrity more than intervention alone. |
| doi_str_mv | 10.1007/s00774-006-0732-x |
| format | Article |
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Walker carcinosarcoma cells were implanted into the left femur of female rats that received 26-day ibandronate pretreatment followed by continued therapy or ibandronate posttreatment only. A tumor-only group received isotonic saline. At endpoint, excised femurs were scanned using microcomputed tomography (microCT) to assess bone volume density, bone mineral content, trabecular number/thickness, and separation for cortical plus trabecular bone or trabecular bone alone. Compared with the nonimplanted right femur, bone volume and surface density and trabecular number and thickness were reduced in the distal left femur following tumor cell implantation. microCT analysis revealed greater cortical and trabecular bone mineral content in the preventative and interventional (pre-post tumor) ibandronate group, and the interventional (post-tumor) ibandronate group, versus the tumor-only group. Bone volume density was significantly higher in pre-post and post-tumor groups compared to the tumor-only group. After preventative and interventional ibandronate, bone volume density and trabecular thickness were 13% and 60% greater, respectively, than in the post-tumor treatment group. 3-D microCT images confirmed microstructural changes. We conclude that combined interventional and preventative ibandronate preserves bone strength and integrity more than intervention alone.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-006-0732-x</identifier><identifier>PMID: 17323177</identifier><language>eng</language><publisher>Tokyo: Springer</publisher><subject>Animals ; Biological and medical sciences ; Bone and Bones - drug effects ; Bone and Bones - pathology ; Bone and Bones - ultrastructure ; Bone Density Conservation Agents - therapeutic use ; Bones ; Bones, joints and connective tissue. Antiinflammatory agents ; Carcinoma 256, Walker - drug therapy ; Carcinoma 256, Walker - pathology ; Diphosphonates - therapeutic use ; Disease Models, Animal ; Diseases of the osteoarticular system ; Female ; Femur - drug effects ; Femur - pathology ; Image Processing, Computer-Assisted ; Medical sciences ; Microstructure ; Osteoporosis ; Pharmacology. Drug treatments ; Rats ; Rodents ; Tumors of striated muscle and skeleton</subject><ispartof>Journal of bone and mineral metabolism, 2007-03, Vol.25 (2), p.86-92</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag Tokyo 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-329435677bee9fbfc4929b264b24782ec5755306a1a8d15a4f89d4d1102387de3</citedby><cites>FETCH-LOGICAL-c424t-329435677bee9fbfc4929b264b24782ec5755306a1a8d15a4f89d4d1102387de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18581221$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17323177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KURTH, Andreas A</creatorcontrib><creatorcontrib>KIM, Soo-Zin</creatorcontrib><creatorcontrib>SHEA, Marie</creatorcontrib><creatorcontrib>BAUSS, Frieder</creatorcontrib><creatorcontrib>HAYES, Wilson C</creatorcontrib><creatorcontrib>MÜLLER, Ralph</creatorcontrib><title>Preventative ibandronate treatment has the most beneficial effect on the microstructure of bone in experimental tumor osteolysis</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><description>We investigated the effect of ibandronate on three-dimensional (3-D) microstructure and bone mass in experimentally induced tumor osteolysis. Walker carcinosarcoma cells were implanted into the left femur of female rats that received 26-day ibandronate pretreatment followed by continued therapy or ibandronate posttreatment only. A tumor-only group received isotonic saline. At endpoint, excised femurs were scanned using microcomputed tomography (microCT) to assess bone volume density, bone mineral content, trabecular number/thickness, and separation for cortical plus trabecular bone or trabecular bone alone. Compared with the nonimplanted right femur, bone volume and surface density and trabecular number and thickness were reduced in the distal left femur following tumor cell implantation. microCT analysis revealed greater cortical and trabecular bone mineral content in the preventative and interventional (pre-post tumor) ibandronate group, and the interventional (post-tumor) ibandronate group, versus the tumor-only group. Bone volume density was significantly higher in pre-post and post-tumor groups compared to the tumor-only group. After preventative and interventional ibandronate, bone volume density and trabecular thickness were 13% and 60% greater, respectively, than in the post-tumor treatment group. 3-D microCT images confirmed microstructural changes. We conclude that combined interventional and preventative ibandronate preserves bone strength and integrity more than intervention alone.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - pathology</subject><subject>Bone and Bones - ultrastructure</subject><subject>Bone Density Conservation Agents - therapeutic use</subject><subject>Bones</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Carcinoma 256, Walker - drug therapy</subject><subject>Carcinoma 256, Walker - pathology</subject><subject>Diphosphonates - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Femur - drug effects</subject><subject>Femur - pathology</subject><subject>Image Processing, Computer-Assisted</subject><subject>Medical sciences</subject><subject>Microstructure</subject><subject>Osteoporosis</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rodents</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU9r3DAQxUVJaTZpP0AvQRCamxuNJFv2MYT-g0B7aM9ClkdEwZY2khw2t370aNmFQC4zh_m9xzweIZ-BfQXG1HWuQ8mGsa5hSvBm945sQIq2aTsmT8iGDSCbXqnhlJzl_MAYqFbBB3IKlRag1Ib8_5PwCUMxxT8h9aMJU4rBFKQloSlLPdF7k2m5R7rEXOiIAZ233swUnUNbaAyHq7epAmm1ZU1Io6NjDNUyUNxtMfm9VRWVdYmJVhDj_Jx9_kjeOzNn_HTc5-Tf929_b382d79__Lq9uWus5LI0gg81WKfUiDi40Vk58GHknRy5VD1H26q2FawzYPoJWiNdP0xyAmBc9GpCcU6uDr7bFB9XzEUvPlucZxMwrlkrxgE6xSp4-QZ8iGsK9TcNAEIqznpZKThQ-9A5odPbGtGkZw1M78vRh3J0LUfvy9G7qrk4Oq_jgtOr4thGBb4cAZOtmV0ywfr8yvVtD5yDeAEyaZlE</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>KURTH, Andreas A</creator><creator>KIM, Soo-Zin</creator><creator>SHEA, Marie</creator><creator>BAUSS, Frieder</creator><creator>HAYES, Wilson C</creator><creator>MÜLLER, Ralph</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Preventative ibandronate treatment has the most beneficial effect on the microstructure of bone in experimental tumor osteolysis</title><author>KURTH, Andreas A ; KIM, Soo-Zin ; SHEA, Marie ; BAUSS, Frieder ; HAYES, Wilson C ; MÜLLER, Ralph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-329435677bee9fbfc4929b264b24782ec5755306a1a8d15a4f89d4d1102387de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - pathology</topic><topic>Bone and Bones - ultrastructure</topic><topic>Bone Density Conservation Agents - therapeutic use</topic><topic>Bones</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Carcinoma 256, Walker - drug therapy</topic><topic>Carcinoma 256, Walker - pathology</topic><topic>Diphosphonates - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Femur - drug effects</topic><topic>Femur - pathology</topic><topic>Image Processing, Computer-Assisted</topic><topic>Medical sciences</topic><topic>Microstructure</topic><topic>Osteoporosis</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rodents</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KURTH, Andreas A</creatorcontrib><creatorcontrib>KIM, Soo-Zin</creatorcontrib><creatorcontrib>SHEA, Marie</creatorcontrib><creatorcontrib>BAUSS, Frieder</creatorcontrib><creatorcontrib>HAYES, Wilson C</creatorcontrib><creatorcontrib>MÜLLER, Ralph</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KURTH, Andreas A</au><au>KIM, Soo-Zin</au><au>SHEA, Marie</au><au>BAUSS, Frieder</au><au>HAYES, Wilson C</au><au>MÜLLER, Ralph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preventative ibandronate treatment has the most beneficial effect on the microstructure of bone in experimental tumor osteolysis</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><addtitle>J Bone Miner Metab</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>25</volume><issue>2</issue><spage>86</spage><epage>92</epage><pages>86-92</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>We investigated the effect of ibandronate on three-dimensional (3-D) microstructure and bone mass in experimentally induced tumor osteolysis. Walker carcinosarcoma cells were implanted into the left femur of female rats that received 26-day ibandronate pretreatment followed by continued therapy or ibandronate posttreatment only. A tumor-only group received isotonic saline. At endpoint, excised femurs were scanned using microcomputed tomography (microCT) to assess bone volume density, bone mineral content, trabecular number/thickness, and separation for cortical plus trabecular bone or trabecular bone alone. Compared with the nonimplanted right femur, bone volume and surface density and trabecular number and thickness were reduced in the distal left femur following tumor cell implantation. microCT analysis revealed greater cortical and trabecular bone mineral content in the preventative and interventional (pre-post tumor) ibandronate group, and the interventional (post-tumor) ibandronate group, versus the tumor-only group. Bone volume density was significantly higher in pre-post and post-tumor groups compared to the tumor-only group. After preventative and interventional ibandronate, bone volume density and trabecular thickness were 13% and 60% greater, respectively, than in the post-tumor treatment group. 3-D microCT images confirmed microstructural changes. We conclude that combined interventional and preventative ibandronate preserves bone strength and integrity more than intervention alone.</abstract><cop>Tokyo</cop><pub>Springer</pub><pmid>17323177</pmid><doi>10.1007/s00774-006-0732-x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Bone and Bones - drug effects Bone and Bones - pathology Bone and Bones - ultrastructure Bone Density Conservation Agents - therapeutic use Bones Bones, joints and connective tissue. Antiinflammatory agents Carcinoma 256, Walker - drug therapy Carcinoma 256, Walker - pathology Diphosphonates - therapeutic use Disease Models, Animal Diseases of the osteoarticular system Female Femur - drug effects Femur - pathology Image Processing, Computer-Assisted Medical sciences Microstructure Osteoporosis Pharmacology. Drug treatments Rats Rodents Tumors of striated muscle and skeleton |
| title | Preventative ibandronate treatment has the most beneficial effect on the microstructure of bone in experimental tumor osteolysis |
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