Mass spectrometric study of dirhenium biscarboxylate:purine dinucleotide complexes
Dirhenium adducts of purine dinucleotides were identified by mass spectrometry. In consecutive studies, Re2(O2C2H3)2Cl4 · 2H2O was reacted with 2′‐deoxyguanylyl(3′→5′)‐2′‐deoxyguanosine (dGpG) and 2′‐deoxyadenylyl(3′→5′)‐2′‐deoxyguanosine (dApG) in H2O or D2O. These reactions were monitored to ident...
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| Veröffentlicht in: | Rapid communications in mass spectrometry 2007-01, Vol.21 (6), p.903-910 |
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| creator | Day, Elizabeth F. Payne, Tiffany A. Holt, Crystal A. |
| description | Dirhenium adducts of purine dinucleotides were identified by mass spectrometry. In consecutive studies, Re2(O2C2H3)2Cl4 · 2H2O was reacted with 2′‐deoxyguanylyl(3′→5′)‐2′‐deoxyguanosine (dGpG) and 2′‐deoxyadenylyl(3′→5′)‐2′‐deoxyguanosine (dApG) in H2O or D2O. These reactions were monitored to identify novel dinuclear rhenium:dinucleotide complexes as confirmed by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS), electrospray ionization mass spectrometry (ESI‐MS) and collision‐induced dissociation tandem mass spectrometry (CID MS/MS) experiments. However, the most abundant adducts detected by ES‐MS were dirhenium:nucleotide species. Of these, guanine‐containing ions were observed with highest ion counts suggesting a preference for guanine coordination. Dimetal adducts showed coordination of the purine bases and common metalated fragments were observed for both dGpG and dApG reactions. Copyright © 2007 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/rcm.2910 |
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In consecutive studies, Re2(O2C2H3)2Cl4 · 2H2O was reacted with 2′‐deoxyguanylyl(3′→5′)‐2′‐deoxyguanosine (dGpG) and 2′‐deoxyadenylyl(3′→5′)‐2′‐deoxyguanosine (dApG) in H2O or D2O. These reactions were monitored to identify novel dinuclear rhenium:dinucleotide complexes as confirmed by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS), electrospray ionization mass spectrometry (ESI‐MS) and collision‐induced dissociation tandem mass spectrometry (CID MS/MS) experiments. However, the most abundant adducts detected by ES‐MS were dirhenium:nucleotide species. Of these, guanine‐containing ions were observed with highest ion counts suggesting a preference for guanine coordination. Dimetal adducts showed coordination of the purine bases and common metalated fragments were observed for both dGpG and dApG reactions. Copyright © 2007 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-4198</identifier><identifier>EISSN: 1097-0231</identifier><identifier>DOI: 10.1002/rcm.2910</identifier><identifier>PMID: 17315275</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Chromatography, Liquid - methods ; Macromolecular Substances - chemistry ; Mass Spectrometry - methods ; Models, Chemical ; Models, Molecular ; Molecular Conformation ; Purine Nucleotides - chemistry ; Rhenium - chemistry</subject><ispartof>Rapid communications in mass spectrometry, 2007-01, Vol.21 (6), p.903-910</ispartof><rights>Copyright © 2007 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3570-ba35d09faf5a33c1bff9e5c0e21a13569316bc47ead510b3a2efd3d6824f323c3</citedby><cites>FETCH-LOGICAL-c3570-ba35d09faf5a33c1bff9e5c0e21a13569316bc47ead510b3a2efd3d6824f323c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Frcm.2910$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Frcm.2910$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17315275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Day, Elizabeth F.</creatorcontrib><creatorcontrib>Payne, Tiffany A.</creatorcontrib><creatorcontrib>Holt, Crystal A.</creatorcontrib><title>Mass spectrometric study of dirhenium biscarboxylate:purine dinucleotide complexes</title><title>Rapid communications in mass spectrometry</title><addtitle>Rapid Commun. Mass Spectrom</addtitle><description>Dirhenium adducts of purine dinucleotides were identified by mass spectrometry. In consecutive studies, Re2(O2C2H3)2Cl4 · 2H2O was reacted with 2′‐deoxyguanylyl(3′→5′)‐2′‐deoxyguanosine (dGpG) and 2′‐deoxyadenylyl(3′→5′)‐2′‐deoxyguanosine (dApG) in H2O or D2O. These reactions were monitored to identify novel dinuclear rhenium:dinucleotide complexes as confirmed by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS), electrospray ionization mass spectrometry (ESI‐MS) and collision‐induced dissociation tandem mass spectrometry (CID MS/MS) experiments. However, the most abundant adducts detected by ES‐MS were dirhenium:nucleotide species. Of these, guanine‐containing ions were observed with highest ion counts suggesting a preference for guanine coordination. Dimetal adducts showed coordination of the purine bases and common metalated fragments were observed for both dGpG and dApG reactions. Copyright © 2007 John Wiley & Sons, Ltd.</description><subject>Chromatography, Liquid - methods</subject><subject>Macromolecular Substances - chemistry</subject><subject>Mass Spectrometry - methods</subject><subject>Models, Chemical</subject><subject>Models, Molecular</subject><subject>Molecular Conformation</subject><subject>Purine Nucleotides - chemistry</subject><subject>Rhenium - chemistry</subject><issn>0951-4198</issn><issn>1097-0231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAQgIMouj7AXyA9iZeuM0mz3XqT9YkvEEXwEtJ0gtF2W5MWd_-9lS168jQD8_ExfIztI4wRgB97U415hrDGRghZGgMXuM5GkEmME8ymW2w7hHcARMlhk21hKvotlSP2eKdDiEJDpvV1Ra13JgptVyyj2kaF8280d10V5S4Y7fN6sSx1SydN592c-vu8MyXVrSsoMnXVlLSgsMs2rC4D7Q1zhz1fnD_NruLbh8vr2eltbIRMIc61kAVkVluphTCYW5uRNEAcNQo5yQROcpOkpAuJkAvNyRaimEx5YgUXRuyww5W38fVnR6FVVf8llaWeU90FlQJHBAk9eLQCja9D8GRV412l_VIhqJ9-qu-nfvr16MHg7PKKij9wCNYD8Qr4ciUt_xWpx9ndIBx4F1pa_PLaf6hJKlKpXu4v1Y1Mzl6nmKgr8Q2tQoo4</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Day, Elizabeth F.</creator><creator>Payne, Tiffany A.</creator><creator>Holt, Crystal A.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Mass spectrometric study of dirhenium biscarboxylate:purine dinucleotide complexes</title><author>Day, Elizabeth F. ; Payne, Tiffany A. ; Holt, Crystal A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3570-ba35d09faf5a33c1bff9e5c0e21a13569316bc47ead510b3a2efd3d6824f323c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Chromatography, Liquid - methods</topic><topic>Macromolecular Substances - chemistry</topic><topic>Mass Spectrometry - methods</topic><topic>Models, Chemical</topic><topic>Models, Molecular</topic><topic>Molecular Conformation</topic><topic>Purine Nucleotides - chemistry</topic><topic>Rhenium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Day, Elizabeth F.</creatorcontrib><creatorcontrib>Payne, Tiffany A.</creatorcontrib><creatorcontrib>Holt, Crystal A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rapid communications in mass spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Day, Elizabeth F.</au><au>Payne, Tiffany A.</au><au>Holt, Crystal A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mass spectrometric study of dirhenium biscarboxylate:purine dinucleotide complexes</atitle><jtitle>Rapid communications in mass spectrometry</jtitle><addtitle>Rapid Commun. Mass Spectrom</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>21</volume><issue>6</issue><spage>903</spage><epage>910</epage><pages>903-910</pages><issn>0951-4198</issn><eissn>1097-0231</eissn><abstract>Dirhenium adducts of purine dinucleotides were identified by mass spectrometry. In consecutive studies, Re2(O2C2H3)2Cl4 · 2H2O was reacted with 2′‐deoxyguanylyl(3′→5′)‐2′‐deoxyguanosine (dGpG) and 2′‐deoxyadenylyl(3′→5′)‐2′‐deoxyguanosine (dApG) in H2O or D2O. These reactions were monitored to identify novel dinuclear rhenium:dinucleotide complexes as confirmed by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS), electrospray ionization mass spectrometry (ESI‐MS) and collision‐induced dissociation tandem mass spectrometry (CID MS/MS) experiments. However, the most abundant adducts detected by ES‐MS were dirhenium:nucleotide species. Of these, guanine‐containing ions were observed with highest ion counts suggesting a preference for guanine coordination. Dimetal adducts showed coordination of the purine bases and common metalated fragments were observed for both dGpG and dApG reactions. Copyright © 2007 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>17315275</pmid><doi>10.1002/rcm.2910</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Chromatography, Liquid - methods Macromolecular Substances - chemistry Mass Spectrometry - methods Models, Chemical Models, Molecular Molecular Conformation Purine Nucleotides - chemistry Rhenium - chemistry |
| title | Mass spectrometric study of dirhenium biscarboxylate:purine dinucleotide complexes |
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