Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL 6J mice
Background: Obesity is strongly associated with female infertility, but the mechanisms underlying this relationship are largely unknown. Methods: We investigated the effect of increasing dietary fat percentage upon body mass, hypothalamic neuropeptide gene expression, adipose hormone secretion and f...
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| Veröffentlicht in: | International Journal of Obesity 2007-03, Vol.31 (3), p.395-402 |
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| creator | Tortoriello, D V McMinn, J E Chua, S C |
| description | Background:
Obesity is strongly associated with female infertility, but the mechanisms underlying this relationship are largely unknown.
Methods:
We investigated the effect of increasing dietary fat percentage upon body mass, hypothalamic neuropeptide gene expression, adipose hormone secretion and fertility in females of the inbred mouse strains C57BL/6J and DBA/2J. To assess the effect of obesity independent of dietary influence, we also compared these parameters in wild-type female C57BL/6J mice to those congenic for the obesogenic mutations
ob
/
ob
and A
y
/a.
Results:
After 24 weeks, rather than exhibiting an obese, leptin-resistant phenotype like their female DBA/2J counterparts, wild-type female C57BL/6J mice remained lean, fertile and manifested increased hypothalamic LEPR-B expression. Although both mutant genotypes were associated with obesity and subfertility,
ob
/
ob
mice demonstrated significantly increased hypothalamic LEPR-B expression, whereas A
y
/a mice had a significant reduction. Interestingly, wild-type female C57BL/6J mice were noted to manifest significantly higher and lower levels of adiponectin and tissue plasminogen activator inhibitor-1 (tPAI-1), respectively, than weight-matched wild-type female DBA/2J mice.
Conclusions:
We conclude that (1) resistance to the obese-infertile phenotype in female C57BL/6J mice is associated with increased hypothalamic leptin receptor expression and alterations in adipokine levels consistent with decreased adipose tissue inflammation and (2) that long-standing hyperleptinemic obesity in mice is associated with a downregulation of the hypothalamic leptin receptor. |
| doi_str_mv | 10.1038/sj.ijo.0803392 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_70210657</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188435148</galeid><sourcerecordid>A188435148</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-9e965fea1c1cdb49e0f12fa746389148d789c5eae830774c7827ad7e3798c8273</originalsourceid><addsrcrecordid>eNp1kk1v1DAQhiMEotvClRvIoqK3bO0kjp1jWfFRtBIXOFteZ9L1KrGD7Ujd_8KPZZYNLKCiHOJknvcdz0eWvWB0yWgpr-NuaXd-SSUty6Z4lC1YJeqcV414nC1oSUVOec3PsvMYd5RSzmnxNDtjtaw5o3SRfb91JoCO0BK4HwPEaL0jviPb_ejTVvd6sIb0MCbrSACDBx-Idi3RrR29A3MIaGP8MGq3RyTamLQzQJInrYWkwz63rp0MpvAbDKf9T711HYRk-8M3WnQw6B7Iiou3a1J_IpgWnmVPOt1HeD6_L7Kv7999WX3M158_3K5u1rnBIlLeQFPzDjQzzLSbqgHasaLToqpL2bBKtkI2hoMGif0QlRGyELoVUIpGGjyXF9nV0XcM_tsEManBRgN9rx34KSpBC0ZrfgBf_wPu_BQc3k0VrCkEp7RB6PII3WFBCsv0KWhzcFQ3TMqq5HgnpJYPUPi0gKVjYzuL__8SXP0h2ILu0zb6fko4sPigswk-xgCdGoMdcAyKUXVYGhV3CpdGzUuDgldzVdNmgPaEz1uCwJsZ0NHovgs4XxtPnOSVEIIjd33kIobcHYRTe_6b-uVR4XSaAvy2_BX_AYPD5BI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219275009</pqid></control><display><type>article</type><title>Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL 6J mice</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Tortoriello, D V ; McMinn, J E ; Chua, S C</creator><creatorcontrib>Tortoriello, D V ; McMinn, J E ; Chua, S C</creatorcontrib><description>Background:
Obesity is strongly associated with female infertility, but the mechanisms underlying this relationship are largely unknown.
Methods:
We investigated the effect of increasing dietary fat percentage upon body mass, hypothalamic neuropeptide gene expression, adipose hormone secretion and fertility in females of the inbred mouse strains C57BL/6J and DBA/2J. To assess the effect of obesity independent of dietary influence, we also compared these parameters in wild-type female C57BL/6J mice to those congenic for the obesogenic mutations
ob
/
ob
and A
y
/a.
Results:
After 24 weeks, rather than exhibiting an obese, leptin-resistant phenotype like their female DBA/2J counterparts, wild-type female C57BL/6J mice remained lean, fertile and manifested increased hypothalamic LEPR-B expression. Although both mutant genotypes were associated with obesity and subfertility,
ob
/
ob
mice demonstrated significantly increased hypothalamic LEPR-B expression, whereas A
y
/a mice had a significant reduction. Interestingly, wild-type female C57BL/6J mice were noted to manifest significantly higher and lower levels of adiponectin and tissue plasminogen activator inhibitor-1 (tPAI-1), respectively, than weight-matched wild-type female DBA/2J mice.
Conclusions:
We conclude that (1) resistance to the obese-infertile phenotype in female C57BL/6J mice is associated with increased hypothalamic leptin receptor expression and alterations in adipokine levels consistent with decreased adipose tissue inflammation and (2) that long-standing hyperleptinemic obesity in mice is associated with a downregulation of the hypothalamic leptin receptor.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0803392</identifier><identifier>PMID: 16865100</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adipocytes ; Adiponectin - blood ; Adipose tissue ; Agouti-Related Protein ; Animals ; Biological and medical sciences ; Body fat ; Body Weight ; Complications and side effects ; Diagnosis ; Dietary Fats - administration & dosage ; Diseases of the digestive system ; Epidemiology ; Feeding. Feeding behavior ; Female ; Females ; Fertility ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; Genotype & phenotype ; Genotypes ; Gonadotropin-Releasing Hormone - analysis ; Health aspects ; Health Promotion and Disease Prevention ; Hypothalamus - chemistry ; Infertility ; Infertility, Female ; Infertility, Female - metabolism ; Inflammation ; Insulin - metabolism ; Intercellular Signaling Peptides and Proteins - analysis ; Internal Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mutation ; Neuropeptide Y - analysis ; Neuropeptides ; Neurotransmitter receptors ; Obesity ; Obesity - metabolism ; original-article ; Pregnancy ; Pro-Opiomelanocortin - analysis ; Public Health ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Receptors, Cell Surface - analysis ; Receptors, Leptin ; Resistin - analysis ; Risk factors ; Tissue Plasminogen Activator - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>International Journal of Obesity, 2007-03, Vol.31 (3), p.395-402</ispartof><rights>Springer Nature Limited 2007</rights><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-9e965fea1c1cdb49e0f12fa746389148d789c5eae830774c7827ad7e3798c8273</citedby><cites>FETCH-LOGICAL-c510t-9e965fea1c1cdb49e0f12fa746389148d789c5eae830774c7827ad7e3798c8273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18547775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16865100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tortoriello, D V</creatorcontrib><creatorcontrib>McMinn, J E</creatorcontrib><creatorcontrib>Chua, S C</creatorcontrib><title>Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL 6J mice</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background:
Obesity is strongly associated with female infertility, but the mechanisms underlying this relationship are largely unknown.
Methods:
We investigated the effect of increasing dietary fat percentage upon body mass, hypothalamic neuropeptide gene expression, adipose hormone secretion and fertility in females of the inbred mouse strains C57BL/6J and DBA/2J. To assess the effect of obesity independent of dietary influence, we also compared these parameters in wild-type female C57BL/6J mice to those congenic for the obesogenic mutations
ob
/
ob
and A
y
/a.
Results:
After 24 weeks, rather than exhibiting an obese, leptin-resistant phenotype like their female DBA/2J counterparts, wild-type female C57BL/6J mice remained lean, fertile and manifested increased hypothalamic LEPR-B expression. Although both mutant genotypes were associated with obesity and subfertility,
ob
/
ob
mice demonstrated significantly increased hypothalamic LEPR-B expression, whereas A
y
/a mice had a significant reduction. Interestingly, wild-type female C57BL/6J mice were noted to manifest significantly higher and lower levels of adiponectin and tissue plasminogen activator inhibitor-1 (tPAI-1), respectively, than weight-matched wild-type female DBA/2J mice.
Conclusions:
We conclude that (1) resistance to the obese-infertile phenotype in female C57BL/6J mice is associated with increased hypothalamic leptin receptor expression and alterations in adipokine levels consistent with decreased adipose tissue inflammation and (2) that long-standing hyperleptinemic obesity in mice is associated with a downregulation of the hypothalamic leptin receptor.</description><subject>Adipocytes</subject><subject>Adiponectin - blood</subject><subject>Adipose tissue</subject><subject>Agouti-Related Protein</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Body Weight</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Dietary Fats - administration & dosage</subject><subject>Diseases of the digestive system</subject><subject>Epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Females</subject><subject>Fertility</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic aspects</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Gonadotropin-Releasing Hormone - analysis</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Hypothalamus - chemistry</subject><subject>Infertility</subject><subject>Infertility, Female</subject><subject>Infertility, Female - metabolism</subject><subject>Inflammation</subject><subject>Insulin - metabolism</subject><subject>Intercellular Signaling Peptides and Proteins - analysis</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Mutation</subject><subject>Neuropeptide Y - analysis</subject><subject>Neuropeptides</subject><subject>Neurotransmitter receptors</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>original-article</subject><subject>Pregnancy</subject><subject>Pro-Opiomelanocortin - analysis</subject><subject>Public Health</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Receptors, Cell Surface - analysis</subject><subject>Receptors, Leptin</subject><subject>Resistin - analysis</subject><subject>Risk factors</subject><subject>Tissue Plasminogen Activator - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1v1DAQhiMEotvClRvIoqK3bO0kjp1jWfFRtBIXOFteZ9L1KrGD7Ujd_8KPZZYNLKCiHOJknvcdz0eWvWB0yWgpr-NuaXd-SSUty6Z4lC1YJeqcV414nC1oSUVOec3PsvMYd5RSzmnxNDtjtaw5o3SRfb91JoCO0BK4HwPEaL0jviPb_ejTVvd6sIb0MCbrSACDBx-Idi3RrR29A3MIaGP8MGq3RyTamLQzQJInrYWkwz63rp0MpvAbDKf9T711HYRk-8M3WnQw6B7Iiou3a1J_IpgWnmVPOt1HeD6_L7Kv7999WX3M158_3K5u1rnBIlLeQFPzDjQzzLSbqgHasaLToqpL2bBKtkI2hoMGif0QlRGyELoVUIpGGjyXF9nV0XcM_tsEManBRgN9rx34KSpBC0ZrfgBf_wPu_BQc3k0VrCkEp7RB6PII3WFBCsv0KWhzcFQ3TMqq5HgnpJYPUPi0gKVjYzuL__8SXP0h2ILu0zb6fko4sPigswk-xgCdGoMdcAyKUXVYGhV3CpdGzUuDgldzVdNmgPaEz1uCwJsZ0NHovgs4XxtPnOSVEIIjd33kIobcHYRTe_6b-uVR4XSaAvy2_BX_AYPD5BI</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Tortoriello, D V</creator><creator>McMinn, J E</creator><creator>Chua, S C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL 6J mice</title><author>Tortoriello, D V ; McMinn, J E ; Chua, S C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-9e965fea1c1cdb49e0f12fa746389148d789c5eae830774c7827ad7e3798c8273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adipocytes</topic><topic>Adiponectin - blood</topic><topic>Adipose tissue</topic><topic>Agouti-Related Protein</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Body Weight</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Dietary Fats - administration & dosage</topic><topic>Diseases of the digestive system</topic><topic>Epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Females</topic><topic>Fertility</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic aspects</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Gonadotropin-Releasing Hormone - analysis</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Hypothalamus - chemistry</topic><topic>Infertility</topic><topic>Infertility, Female</topic><topic>Infertility, Female - metabolism</topic><topic>Inflammation</topic><topic>Insulin - metabolism</topic><topic>Intercellular Signaling Peptides and Proteins - analysis</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Mutation</topic><topic>Neuropeptide Y - analysis</topic><topic>Neuropeptides</topic><topic>Neurotransmitter receptors</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>original-article</topic><topic>Pregnancy</topic><topic>Pro-Opiomelanocortin - analysis</topic><topic>Public Health</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Receptors, Cell Surface - analysis</topic><topic>Receptors, Leptin</topic><topic>Resistin - analysis</topic><topic>Risk factors</topic><topic>Tissue Plasminogen Activator - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tortoriello, D V</creatorcontrib><creatorcontrib>McMinn, J E</creatorcontrib><creatorcontrib>Chua, S C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tortoriello, D V</au><au>McMinn, J E</au><au>Chua, S C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL 6J mice</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>31</volume><issue>3</issue><spage>395</spage><epage>402</epage><pages>395-402</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>Background:
Obesity is strongly associated with female infertility, but the mechanisms underlying this relationship are largely unknown.
Methods:
We investigated the effect of increasing dietary fat percentage upon body mass, hypothalamic neuropeptide gene expression, adipose hormone secretion and fertility in females of the inbred mouse strains C57BL/6J and DBA/2J. To assess the effect of obesity independent of dietary influence, we also compared these parameters in wild-type female C57BL/6J mice to those congenic for the obesogenic mutations
ob
/
ob
and A
y
/a.
Results:
After 24 weeks, rather than exhibiting an obese, leptin-resistant phenotype like their female DBA/2J counterparts, wild-type female C57BL/6J mice remained lean, fertile and manifested increased hypothalamic LEPR-B expression. Although both mutant genotypes were associated with obesity and subfertility,
ob
/
ob
mice demonstrated significantly increased hypothalamic LEPR-B expression, whereas A
y
/a mice had a significant reduction. Interestingly, wild-type female C57BL/6J mice were noted to manifest significantly higher and lower levels of adiponectin and tissue plasminogen activator inhibitor-1 (tPAI-1), respectively, than weight-matched wild-type female DBA/2J mice.
Conclusions:
We conclude that (1) resistance to the obese-infertile phenotype in female C57BL/6J mice is associated with increased hypothalamic leptin receptor expression and alterations in adipokine levels consistent with decreased adipose tissue inflammation and (2) that long-standing hyperleptinemic obesity in mice is associated with a downregulation of the hypothalamic leptin receptor.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16865100</pmid><doi>10.1038/sj.ijo.0803392</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2007-03, Vol.31 (3), p.395-402 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70210657 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adipocytes Adiponectin - blood Adipose tissue Agouti-Related Protein Animals Biological and medical sciences Body fat Body Weight Complications and side effects Diagnosis Dietary Fats - administration & dosage Diseases of the digestive system Epidemiology Feeding. Feeding behavior Female Females Fertility Fundamental and applied biological sciences. Psychology Genetic aspects Genotype & phenotype Genotypes Gonadotropin-Releasing Hormone - analysis Health aspects Health Promotion and Disease Prevention Hypothalamus - chemistry Infertility Infertility, Female Infertility, Female - metabolism Inflammation Insulin - metabolism Intercellular Signaling Peptides and Proteins - analysis Internal Medicine Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Mice, Inbred DBA Mutation Neuropeptide Y - analysis Neuropeptides Neurotransmitter receptors Obesity Obesity - metabolism original-article Pregnancy Pro-Opiomelanocortin - analysis Public Health Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Receptors, Cell Surface - analysis Receptors, Leptin Resistin - analysis Risk factors Tissue Plasminogen Activator - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Increased expression of hypothalamic leptin receptor and adiponectin accompany resistance to dietary-induced obesity and infertility in female C57BL 6J mice |
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