Does sentinel node biopsy improve the management of endometrial cancer? Data from 43 patients
Objectives To map sentinel lymph nodes (SLNs) detected by intracervical injection in patients with endometrial cancer and to determine the prevalence of node micrometastases. Methods Radionuclide and blue dye injections were used for SLN detection in 43 patients with clinical stage I endometrial can...
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| Veröffentlicht in: | Journal of surgical oncology 2008-02, Vol.97 (2), p.141-145 |
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| container_title | Journal of surgical oncology |
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| creator | Bats, Anne-Sophie Clément, Denys Larousserie, Florence Le Frère-Belda, Marie-Aude Pierquet-Ghazzar, Nadia Hignette, Chantal Lécuru, Fabrice |
| description | Objectives
To map sentinel lymph nodes (SLNs) detected by intracervical injection in patients with endometrial cancer and to determine the prevalence of node micrometastases.
Methods
Radionuclide and blue dye injections were used for SLN detection in 43 patients with clinical stage I endometrial cancer. Lymphoscintigraphy was done before surgery. Intraoperatively, the pelvic and para‐aortic territories were examined for blue and/or radioactive nodes. Pelvic lymphadenectomy was performed with or without para‐aortic lymphadenectomy. SLNs stained with hematoxylin‐eosin‐saffron were examined and, when negative, evaluated using step sectioning and immunohistochemistry.
Results
Feasibility was 100%. No adverse effects occurred. SLNs were identified in 30 patients (69.8%), usually in an interiliac location (28/30 patients, 93.3%). SLNs were found only in the common iliac chain in 1 (3%) patient and in both the common iliac chain and promontory area in another (3%). No patients had para‐aortic SLNs or SLNs confined to the promontory. Node metastases were identified in eight patients and were confined to SLNs in six. In 2 (2/30, 6%) patients, SLNs contained micrometastases. No false‐negatives occurred.
Conclusions
Intracervical injection of radionuclide and blue dye chiefly revealed pelvic SLNs. The prevalence of micrometastases was within the expected range. Comparisons with peritumoral injection are needed. J. Surg. Oncol. 2008;97:141–145. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jso.20857 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70210484</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70210484</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4277-136377f4f94aa8319555a6f3ca2500eed0ca6c05754396c01662e3967bd03c953</originalsourceid><addsrcrecordid>eNp1kE1v1DAQhi0EotvCgT9Q-YTEIe04_opPCLb0S6v2AAguyPI6k9ZtEi92tnT_PYZd4MRpRprnfTV6CHnF4IgB1Md3OR7V0Ej9hMwYGFUZMM1TMiu3uhLawB7Zz_kOAIxR4jnZYw1IqBs1I99OImaacZzCiD0dY4t0GeIqb2gYVik-IJ1ukQ5udDc4FIzGjuLYxgGnFFxPvRs9prf0xE2OdikOVHC6clMobH5BnnWuz_hyNw_I59MPn-bn1eL67GL-blF5UWtdMa641p3ojHCu4cxIKZ3quHe1BEBswTvlQWopuCkLU6rGsullC9wbyQ_I621v-fj7GvNkh5A99r0bMa6z1VAzEI0o4Jst6FPMOWFnVykMLm0sA_vLpS0u7W-XhT3cla6XA7b_yJ28AhxvgR-hx83_m-zlx-s_ldU2EfKEj38TLt1bpbmW9svVmV1ccvb1ar6w7_lPsE-MIg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70210484</pqid></control><display><type>article</type><title>Does sentinel node biopsy improve the management of endometrial cancer? Data from 43 patients</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Bats, Anne-Sophie ; Clément, Denys ; Larousserie, Florence ; Le Frère-Belda, Marie-Aude ; Pierquet-Ghazzar, Nadia ; Hignette, Chantal ; Lécuru, Fabrice</creator><creatorcontrib>Bats, Anne-Sophie ; Clément, Denys ; Larousserie, Florence ; Le Frère-Belda, Marie-Aude ; Pierquet-Ghazzar, Nadia ; Hignette, Chantal ; Lécuru, Fabrice</creatorcontrib><description>Objectives
To map sentinel lymph nodes (SLNs) detected by intracervical injection in patients with endometrial cancer and to determine the prevalence of node micrometastases.
Methods
Radionuclide and blue dye injections were used for SLN detection in 43 patients with clinical stage I endometrial cancer. Lymphoscintigraphy was done before surgery. Intraoperatively, the pelvic and para‐aortic territories were examined for blue and/or radioactive nodes. Pelvic lymphadenectomy was performed with or without para‐aortic lymphadenectomy. SLNs stained with hematoxylin‐eosin‐saffron were examined and, when negative, evaluated using step sectioning and immunohistochemistry.
Results
Feasibility was 100%. No adverse effects occurred. SLNs were identified in 30 patients (69.8%), usually in an interiliac location (28/30 patients, 93.3%). SLNs were found only in the common iliac chain in 1 (3%) patient and in both the common iliac chain and promontory area in another (3%). No patients had para‐aortic SLNs or SLNs confined to the promontory. Node metastases were identified in eight patients and were confined to SLNs in six. In 2 (2/30, 6%) patients, SLNs contained micrometastases. No false‐negatives occurred.
Conclusions
Intracervical injection of radionuclide and blue dye chiefly revealed pelvic SLNs. The prevalence of micrometastases was within the expected range. Comparisons with peritumoral injection are needed. J. Surg. Oncol. 2008;97:141–145. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.20857</identifier><identifier>PMID: 18050286</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Endometrioid - surgery ; Coloring Agents ; endometrial cancer ; Endometrial Neoplasms - surgery ; Feasibility Studies ; Female ; Humans ; Immunohistochemistry ; Intraoperative Care ; laparoscopy ; Lymph Node Excision ; Lymph Nodes - diagnostic imaging ; Lymph Nodes - pathology ; Lymphatic Metastasis - diagnosis ; lymphoscintigraphy ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Radionuclide Imaging ; Radiopharmaceuticals ; Rhenium ; Rosaniline Dyes ; Sentinel Lymph Node Biopsy ; Technetium Tc 99m Sulfur Colloid ; Treatment Outcome</subject><ispartof>Journal of surgical oncology, 2008-02, Vol.97 (2), p.141-145</ispartof><rights>Copyright © 2007 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4277-136377f4f94aa8319555a6f3ca2500eed0ca6c05754396c01662e3967bd03c953</citedby><cites>FETCH-LOGICAL-c4277-136377f4f94aa8319555a6f3ca2500eed0ca6c05754396c01662e3967bd03c953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.20857$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.20857$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18050286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bats, Anne-Sophie</creatorcontrib><creatorcontrib>Clément, Denys</creatorcontrib><creatorcontrib>Larousserie, Florence</creatorcontrib><creatorcontrib>Le Frère-Belda, Marie-Aude</creatorcontrib><creatorcontrib>Pierquet-Ghazzar, Nadia</creatorcontrib><creatorcontrib>Hignette, Chantal</creatorcontrib><creatorcontrib>Lécuru, Fabrice</creatorcontrib><title>Does sentinel node biopsy improve the management of endometrial cancer? Data from 43 patients</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Objectives
To map sentinel lymph nodes (SLNs) detected by intracervical injection in patients with endometrial cancer and to determine the prevalence of node micrometastases.
Methods
Radionuclide and blue dye injections were used for SLN detection in 43 patients with clinical stage I endometrial cancer. Lymphoscintigraphy was done before surgery. Intraoperatively, the pelvic and para‐aortic territories were examined for blue and/or radioactive nodes. Pelvic lymphadenectomy was performed with or without para‐aortic lymphadenectomy. SLNs stained with hematoxylin‐eosin‐saffron were examined and, when negative, evaluated using step sectioning and immunohistochemistry.
Results
Feasibility was 100%. No adverse effects occurred. SLNs were identified in 30 patients (69.8%), usually in an interiliac location (28/30 patients, 93.3%). SLNs were found only in the common iliac chain in 1 (3%) patient and in both the common iliac chain and promontory area in another (3%). No patients had para‐aortic SLNs or SLNs confined to the promontory. Node metastases were identified in eight patients and were confined to SLNs in six. In 2 (2/30, 6%) patients, SLNs contained micrometastases. No false‐negatives occurred.
Conclusions
Intracervical injection of radionuclide and blue dye chiefly revealed pelvic SLNs. The prevalence of micrometastases was within the expected range. Comparisons with peritumoral injection are needed. J. Surg. Oncol. 2008;97:141–145. © 2007 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Endometrioid - surgery</subject><subject>Coloring Agents</subject><subject>endometrial cancer</subject><subject>Endometrial Neoplasms - surgery</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intraoperative Care</subject><subject>laparoscopy</subject><subject>Lymph Node Excision</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>lymphoscintigraphy</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Rhenium</subject><subject>Rosaniline Dyes</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Technetium Tc 99m Sulfur Colloid</subject><subject>Treatment Outcome</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EotvCgT9Q-YTEIe04_opPCLb0S6v2AAguyPI6k9ZtEi92tnT_PYZd4MRpRprnfTV6CHnF4IgB1Md3OR7V0Ej9hMwYGFUZMM1TMiu3uhLawB7Zz_kOAIxR4jnZYw1IqBs1I99OImaacZzCiD0dY4t0GeIqb2gYVik-IJ1ukQ5udDc4FIzGjuLYxgGnFFxPvRs9prf0xE2OdikOVHC6clMobH5BnnWuz_hyNw_I59MPn-bn1eL67GL-blF5UWtdMa641p3ojHCu4cxIKZ3quHe1BEBswTvlQWopuCkLU6rGsullC9wbyQ_I621v-fj7GvNkh5A99r0bMa6z1VAzEI0o4Jst6FPMOWFnVykMLm0sA_vLpS0u7W-XhT3cla6XA7b_yJ28AhxvgR-hx83_m-zlx-s_ldU2EfKEj38TLt1bpbmW9svVmV1ccvb1ar6w7_lPsE-MIg</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Bats, Anne-Sophie</creator><creator>Clément, Denys</creator><creator>Larousserie, Florence</creator><creator>Le Frère-Belda, Marie-Aude</creator><creator>Pierquet-Ghazzar, Nadia</creator><creator>Hignette, Chantal</creator><creator>Lécuru, Fabrice</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>Does sentinel node biopsy improve the management of endometrial cancer? Data from 43 patients</title><author>Bats, Anne-Sophie ; Clément, Denys ; Larousserie, Florence ; Le Frère-Belda, Marie-Aude ; Pierquet-Ghazzar, Nadia ; Hignette, Chantal ; Lécuru, Fabrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4277-136377f4f94aa8319555a6f3ca2500eed0ca6c05754396c01662e3967bd03c953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Endometrioid - surgery</topic><topic>Coloring Agents</topic><topic>endometrial cancer</topic><topic>Endometrial Neoplasms - surgery</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intraoperative Care</topic><topic>laparoscopy</topic><topic>Lymph Node Excision</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>lymphoscintigraphy</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Rhenium</topic><topic>Rosaniline Dyes</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Technetium Tc 99m Sulfur Colloid</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bats, Anne-Sophie</creatorcontrib><creatorcontrib>Clément, Denys</creatorcontrib><creatorcontrib>Larousserie, Florence</creatorcontrib><creatorcontrib>Le Frère-Belda, Marie-Aude</creatorcontrib><creatorcontrib>Pierquet-Ghazzar, Nadia</creatorcontrib><creatorcontrib>Hignette, Chantal</creatorcontrib><creatorcontrib>Lécuru, Fabrice</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bats, Anne-Sophie</au><au>Clément, Denys</au><au>Larousserie, Florence</au><au>Le Frère-Belda, Marie-Aude</au><au>Pierquet-Ghazzar, Nadia</au><au>Hignette, Chantal</au><au>Lécuru, Fabrice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does sentinel node biopsy improve the management of endometrial cancer? Data from 43 patients</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>97</volume><issue>2</issue><spage>141</spage><epage>145</epage><pages>141-145</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Objectives
To map sentinel lymph nodes (SLNs) detected by intracervical injection in patients with endometrial cancer and to determine the prevalence of node micrometastases.
Methods
Radionuclide and blue dye injections were used for SLN detection in 43 patients with clinical stage I endometrial cancer. Lymphoscintigraphy was done before surgery. Intraoperatively, the pelvic and para‐aortic territories were examined for blue and/or radioactive nodes. Pelvic lymphadenectomy was performed with or without para‐aortic lymphadenectomy. SLNs stained with hematoxylin‐eosin‐saffron were examined and, when negative, evaluated using step sectioning and immunohistochemistry.
Results
Feasibility was 100%. No adverse effects occurred. SLNs were identified in 30 patients (69.8%), usually in an interiliac location (28/30 patients, 93.3%). SLNs were found only in the common iliac chain in 1 (3%) patient and in both the common iliac chain and promontory area in another (3%). No patients had para‐aortic SLNs or SLNs confined to the promontory. Node metastases were identified in eight patients and were confined to SLNs in six. In 2 (2/30, 6%) patients, SLNs contained micrometastases. No false‐negatives occurred.
Conclusions
Intracervical injection of radionuclide and blue dye chiefly revealed pelvic SLNs. The prevalence of micrometastases was within the expected range. Comparisons with peritumoral injection are needed. J. Surg. Oncol. 2008;97:141–145. © 2007 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18050286</pmid><doi>10.1002/jso.20857</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0022-4790 |
| ispartof | Journal of surgical oncology, 2008-02, Vol.97 (2), p.141-145 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Aged, 80 and over Carcinoma, Endometrioid - surgery Coloring Agents endometrial cancer Endometrial Neoplasms - surgery Feasibility Studies Female Humans Immunohistochemistry Intraoperative Care laparoscopy Lymph Node Excision Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Lymphatic Metastasis - diagnosis lymphoscintigraphy Middle Aged Predictive Value of Tests Prospective Studies Radionuclide Imaging Radiopharmaceuticals Rhenium Rosaniline Dyes Sentinel Lymph Node Biopsy Technetium Tc 99m Sulfur Colloid Treatment Outcome |
| title | Does sentinel node biopsy improve the management of endometrial cancer? Data from 43 patients |
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