Multiple Rare Nonsynonymous Variants in the Adenomatous Polyposis Coli Gene Predispose to Colorectal Adenomas

It has been proposed that multiple rare variants in numerous genes collectively account for a substantial proportion of multifactorial inherited predisposition to a variety of diseases, including colorectal adenomas (CRA). We have studied this hypothesis by sequencing the adenomatous polyposis coli...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-01, Vol.68 (2), p.358-363
Hauptverfasser:	AZZOPARDI, Duncan, DALLOSSO, Anthony R, WENSTRUP, Richard, SCHOLL, Thomas, CHEADLE, Jeremy P, ELIASON, Kristilyn, HENDRICKSON, Brant C, JONES, Natalie, RAWSTORNE, Edward, COLLEY, James, MOSKVINA, Valentina, FRYE, Cynthia, SAMPSON, Julian R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenomatous Polyposis Coli Protein - genetics Adult Antineoplastic agents beta Catenin - metabolism Biological and medical sciences Case-Control Studies Colorectal Neoplasms - genetics DNA Mutational Analysis Down-Regulation Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Predisposition to Disease Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Polymorphism, Single Nucleotide - physiology Protein Structure, Tertiary Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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