Extracellular glutamate and GABA in the ventral tegmental area of alcohol-preferring AA and alcohol-avoiding ANA rats treated repeatedly with morphine
Glutamate and γ-amino-butyric acid (GABA) have been implicated in neuronal plasticity related to behavioral sensitization. In the present study, we examined morphine-induced changes in the extracellular concentrations of glutamate and GABA in the ventral tegmental area in alcohol-preferring Alko Alc...
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| Veröffentlicht in: | European journal of pharmacology 2007-03, Vol.559 (1), p.38-45 |
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| creator | Ojanen, Sami P. Palmén, Maria Hyytiä, Petri Kiianmaa, Kalervo |
| description | Glutamate and γ-amino-butyric acid (GABA) have been implicated in neuronal plasticity related to behavioral sensitization. In the present study, we examined morphine-induced changes in the extracellular concentrations of glutamate and GABA in the ventral tegmental area in alcohol-preferring Alko Alcohol (AA) and alcohol-avoiding Alko Non-Alcohol (ANA) rats that have previously been shown to differ in morphine-induced sensitization. The rats were given escalating doses (5–20 mg/kg) of morphine every other day for five days. This treatment produced behavioral sensitization to locomotor effects of morphine in AA, but not in ANA rats, when challenged with an additional injection of morphine (10 mg/kg) 10 days later. Morphine also increased the levels of glutamate in the ventral tegmental area only in AA rats, while no significant changes were found in the extracellular concentrations of GABA between the lines. Challenging the morphine-treated AA rats with ethanol (1.5 g/kg) did not modify the levels of glutamate or GABA. No changes in the concentrations of glutamate or GABA were seen in saline-treated AA and ANA rats after morphine challenge. These results render increased glutamate transmission in the ventral tegmental area a potential contributor to the higher susceptibility of AA rats to morphine-induced behavioral and neurochemical effects relative to ANA rats. |
| doi_str_mv | 10.1016/j.ejphar.2006.11.046 |
| format | Article |
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In the present study, we examined morphine-induced changes in the extracellular concentrations of glutamate and GABA in the ventral tegmental area in alcohol-preferring Alko Alcohol (AA) and alcohol-avoiding Alko Non-Alcohol (ANA) rats that have previously been shown to differ in morphine-induced sensitization. The rats were given escalating doses (5–20 mg/kg) of morphine every other day for five days. This treatment produced behavioral sensitization to locomotor effects of morphine in AA, but not in ANA rats, when challenged with an additional injection of morphine (10 mg/kg) 10 days later. Morphine also increased the levels of glutamate in the ventral tegmental area only in AA rats, while no significant changes were found in the extracellular concentrations of GABA between the lines. Challenging the morphine-treated AA rats with ethanol (1.5 g/kg) did not modify the levels of glutamate or GABA. No changes in the concentrations of glutamate or GABA were seen in saline-treated AA and ANA rats after morphine challenge. These results render increased glutamate transmission in the ventral tegmental area a potential contributor to the higher susceptibility of AA rats to morphine-induced behavioral and neurochemical effects relative to ANA rats.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2006.11.046</identifier><identifier>PMID: 17198699</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alcohol Drinking - genetics ; Alcohol Drinking - metabolism ; Alcohol Drinking - psychology ; Analgesics, Opioid - pharmacology ; Animals ; Behavioral sensitization ; Biological and medical sciences ; Ethanol ; Excitatory amino acids ; Extracellular Space - drug effects ; Extracellular Space - metabolism ; gamma-Aminobutyric Acid - metabolism ; Glutamic Acid - metabolism ; Indicators and Reagents ; Male ; Medical sciences ; Microdialysis ; Morphine - pharmacology ; Motor Activity - drug effects ; Pharmacology. Drug treatments ; Rats ; Selected lines ; Ventral Tegmental Area - metabolism ; Ventral Tegmental Area - pathology</subject><ispartof>European journal of pharmacology, 2007-03, Vol.559 (1), p.38-45</ispartof><rights>2006 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-e749606df6a3c769fbb3369997f77ac9d5d4186d4a4a31f1cbcf77a5a95e891f3</citedby><cites>FETCH-LOGICAL-c390t-e749606df6a3c769fbb3369997f77ac9d5d4186d4a4a31f1cbcf77a5a95e891f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014299906013227$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18553464$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17198699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ojanen, Sami P.</creatorcontrib><creatorcontrib>Palmén, Maria</creatorcontrib><creatorcontrib>Hyytiä, Petri</creatorcontrib><creatorcontrib>Kiianmaa, Kalervo</creatorcontrib><title>Extracellular glutamate and GABA in the ventral tegmental area of alcohol-preferring AA and alcohol-avoiding ANA rats treated repeatedly with morphine</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Glutamate and γ-amino-butyric acid (GABA) have been implicated in neuronal plasticity related to behavioral sensitization. In the present study, we examined morphine-induced changes in the extracellular concentrations of glutamate and GABA in the ventral tegmental area in alcohol-preferring Alko Alcohol (AA) and alcohol-avoiding Alko Non-Alcohol (ANA) rats that have previously been shown to differ in morphine-induced sensitization. The rats were given escalating doses (5–20 mg/kg) of morphine every other day for five days. This treatment produced behavioral sensitization to locomotor effects of morphine in AA, but not in ANA rats, when challenged with an additional injection of morphine (10 mg/kg) 10 days later. Morphine also increased the levels of glutamate in the ventral tegmental area only in AA rats, while no significant changes were found in the extracellular concentrations of GABA between the lines. Challenging the morphine-treated AA rats with ethanol (1.5 g/kg) did not modify the levels of glutamate or GABA. No changes in the concentrations of glutamate or GABA were seen in saline-treated AA and ANA rats after morphine challenge. These results render increased glutamate transmission in the ventral tegmental area a potential contributor to the higher susceptibility of AA rats to morphine-induced behavioral and neurochemical effects relative to ANA rats.</description><subject>Alcohol Drinking - genetics</subject><subject>Alcohol Drinking - metabolism</subject><subject>Alcohol Drinking - psychology</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Behavioral sensitization</subject><subject>Biological and medical sciences</subject><subject>Ethanol</subject><subject>Excitatory amino acids</subject><subject>Extracellular Space - drug effects</subject><subject>Extracellular Space - metabolism</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Glutamic Acid - metabolism</subject><subject>Indicators and Reagents</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microdialysis</subject><subject>Morphine - pharmacology</subject><subject>Motor Activity - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Selected lines</subject><subject>Ventral Tegmental Area - metabolism</subject><subject>Ventral Tegmental Area - pathology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO1DAQRS0EYpqBP0DIG9gl2Hk47Q1SGA0D0gg2sLaq7UrHLeeB7TTMj_C9ON2NZsfKV65zS1V1CXnNWc4ZF-8POR7mHnxeMCZyznNWiSdkw7eNzFjDi6dkwxivskJKeUVehHBgjNWyqJ-TK95wuRVSbsif29_Rg0bnFgee7t0SYYCIFEZD79qPLbUjjT3SI44JdDTifkgyKfAIdOooOD31k8tmjx16b8c9bduT_18FjpM1p_-vLfUQA43JG9FQj_NJuAf6y8aeDpOfezviS_KsAxfw1eW9Jj8-3X6_-Zzdf7v7ctPeZ7qULGbYVFIwYToBpW6E7Ha7skx7yaZrGtDS1KbiW2EqqKDkHdc7vRZqkDVuJe_Ka_Lu3Hf2088FQ1SDDes1YMRpCaphBV_PlsDqDGo_hZA2VbO3A_gHxZla81AHdc5DrXkozlXKI9neXPovuwHNo-kSQALeXgAIGlznYdQ2PHLbui4rUSXuw5nDdI2jRa-CtjhqNNajjspM9v-T_AUWqa1I</recordid><startdate>20070315</startdate><enddate>20070315</enddate><creator>Ojanen, Sami P.</creator><creator>Palmén, Maria</creator><creator>Hyytiä, Petri</creator><creator>Kiianmaa, Kalervo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070315</creationdate><title>Extracellular glutamate and GABA in the ventral tegmental area of alcohol-preferring AA and alcohol-avoiding ANA rats treated repeatedly with morphine</title><author>Ojanen, Sami P. ; Palmén, Maria ; Hyytiä, Petri ; Kiianmaa, Kalervo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-e749606df6a3c769fbb3369997f77ac9d5d4186d4a4a31f1cbcf77a5a95e891f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alcohol Drinking - genetics</topic><topic>Alcohol Drinking - metabolism</topic><topic>Alcohol Drinking - psychology</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Behavioral sensitization</topic><topic>Biological and medical sciences</topic><topic>Ethanol</topic><topic>Excitatory amino acids</topic><topic>Extracellular Space - drug effects</topic><topic>Extracellular Space - metabolism</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Glutamic Acid - metabolism</topic><topic>Indicators and Reagents</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microdialysis</topic><topic>Morphine - pharmacology</topic><topic>Motor Activity - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Selected lines</topic><topic>Ventral Tegmental Area - metabolism</topic><topic>Ventral Tegmental Area - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ojanen, Sami P.</creatorcontrib><creatorcontrib>Palmén, Maria</creatorcontrib><creatorcontrib>Hyytiä, Petri</creatorcontrib><creatorcontrib>Kiianmaa, Kalervo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ojanen, Sami P.</au><au>Palmén, Maria</au><au>Hyytiä, Petri</au><au>Kiianmaa, Kalervo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracellular glutamate and GABA in the ventral tegmental area of alcohol-preferring AA and alcohol-avoiding ANA rats treated repeatedly with morphine</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2007-03-15</date><risdate>2007</risdate><volume>559</volume><issue>1</issue><spage>38</spage><epage>45</epage><pages>38-45</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Glutamate and γ-amino-butyric acid (GABA) have been implicated in neuronal plasticity related to behavioral sensitization. In the present study, we examined morphine-induced changes in the extracellular concentrations of glutamate and GABA in the ventral tegmental area in alcohol-preferring Alko Alcohol (AA) and alcohol-avoiding Alko Non-Alcohol (ANA) rats that have previously been shown to differ in morphine-induced sensitization. The rats were given escalating doses (5–20 mg/kg) of morphine every other day for five days. This treatment produced behavioral sensitization to locomotor effects of morphine in AA, but not in ANA rats, when challenged with an additional injection of morphine (10 mg/kg) 10 days later. Morphine also increased the levels of glutamate in the ventral tegmental area only in AA rats, while no significant changes were found in the extracellular concentrations of GABA between the lines. Challenging the morphine-treated AA rats with ethanol (1.5 g/kg) did not modify the levels of glutamate or GABA. No changes in the concentrations of glutamate or GABA were seen in saline-treated AA and ANA rats after morphine challenge. These results render increased glutamate transmission in the ventral tegmental area a potential contributor to the higher susceptibility of AA rats to morphine-induced behavioral and neurochemical effects relative to ANA rats.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17198699</pmid><doi>10.1016/j.ejphar.2006.11.046</doi><tpages>8</tpages></addata></record> |
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| subjects | Alcohol Drinking - genetics Alcohol Drinking - metabolism Alcohol Drinking - psychology Analgesics, Opioid - pharmacology Animals Behavioral sensitization Biological and medical sciences Ethanol Excitatory amino acids Extracellular Space - drug effects Extracellular Space - metabolism gamma-Aminobutyric Acid - metabolism Glutamic Acid - metabolism Indicators and Reagents Male Medical sciences Microdialysis Morphine - pharmacology Motor Activity - drug effects Pharmacology. Drug treatments Rats Selected lines Ventral Tegmental Area - metabolism Ventral Tegmental Area - pathology |
| title | Extracellular glutamate and GABA in the ventral tegmental area of alcohol-preferring AA and alcohol-avoiding ANA rats treated repeatedly with morphine |
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