Impact of Bacteremia on the Pathogenesis of Experimental Pneumococcal Meningitis

Background. Bacteremia plays a major role in the outcome of pneumococcal meningitis. This experimental study investigated how bacteremia influences the pathophysiologic profile of the brain. Methods. Rats with Streptococcus pneumoniae meningitis were randomized to 1 of 3 groups of infected study rat...

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Veröffentlicht in:	The Journal of infectious diseases 2008-01, Vol.197 (2), p.235-244
Hauptverfasser:	Brandt, Christian T., Holm, David, Liptrot, Matthew, Østergaard, Christian, Lundgren, Jens D., Frimodt-Møller, Niels, Skovsted, Ian C., Rowland, Ian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteremia Bacteremia - immunology Bacteremia - microbiology Bacteria Bacterial diseases Bacterial load Bacterial sepsis Bacteriology Biological and medical sciences Blood Blood - microbiology Blood brain barrier Blood-Brain Barrier - pathology Brain - microbiology Brain - pathology Brain Edema - pathology Cerebrospinal Fluid - microbiology Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Imaging Infections Infectious diseases Inflammation - immunology Inflammation - microbiology Inflammation - physiopathology Magnetic Resonance Imaging Male Medical sciences Meningitis, Pneumococcal - immunology Meningitis, Pneumococcal - microbiology Meningitis, Pneumococcal - pathology Meningitis, Pneumococcal - physiopathology Microbiology Miscellaneous Motor Skills Nervous system diseases Pathology Pneumococcal meningitis Rats Rats, Wistar Severity of Illness Index Streptococcus Streptococcus pneumoniae Streptococcus pneumoniae - isolation & purification Streptococcus pneumoniae - pathogenicity
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