Nicorandil decreases cardiac events during and after noncardiac surgery
Abstract Study Objective To assess whether nicorandil reduces the likelihood of cardiac events during and after intermediate risk surgery. Design Multicenter study. Setting 13 hospitals in Japan. Patients Intermediate-risk patients were identified by the presence of risk factors such as angina, a hi...
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| Veröffentlicht in: | Journal of clinical anesthesia 2007-02, Vol.19 (1), p.44-48 |
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| creator | Kashimoto, Satoshi, MD Seki, Makoto, MD Ishiguro, Toshihiko, MD Yoshioka, Hitoshi, MD Nagata, Osamu, MD Nishimura, Kinya, MD Kikuchi, Toshihiro, MD Yamada, Tatsuya, MD Iwade, Motoyo, MD Omi, Akibumi, MD Honda, Osamu, MD Sakamoto, Atsuhiro, MD Ogihara, Yukihiko, MD Fujimoto, Keiko, MD Nakaigawa, Yasushi, MD Kato, Jitsu, MD Watanabe, Akio, MD Nomura, Minoru, MD Takeda, Junzo, MD |
| description | Abstract Study Objective To assess whether nicorandil reduces the likelihood of cardiac events during and after intermediate risk surgery. Design Multicenter study. Setting 13 hospitals in Japan. Patients Intermediate-risk patients were identified by the presence of risk factors such as angina, a history of myocardial infarction, heart failure, diabetes mellitus, and abnormal electrocardiography (ECG). Interventions Nicorandil was given to these patients during the operation. Measurements and Main Results Cardiac events during the operation and the following 5 days were monitored. The frequency of cardiac events in nicorandil-treated patients was compared with those in nontreated patients. Eighty-four patients received nicorandil during surgery and 237 patients received standard care. Cardiac events in the nicorandil-treated group occurred less frequently both during the operation (odds ratio, 0.15; 95% confidence interval, 0.03-0.76; P = 0.02) and after it (odds ratio, 0.24; 95% confidence interval, 0.06-0.90; P = 0.04). Conclusions Nicorandil reduces the frequency of cardiac events in patients undergoing noncardiac surgery, both during and after the operation. |
| doi_str_mv | 10.1016/j.jclinane.2006.05.023 |
| format | Article |
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Design Multicenter study. Setting 13 hospitals in Japan. Patients Intermediate-risk patients were identified by the presence of risk factors such as angina, a history of myocardial infarction, heart failure, diabetes mellitus, and abnormal electrocardiography (ECG). Interventions Nicorandil was given to these patients during the operation. Measurements and Main Results Cardiac events during the operation and the following 5 days were monitored. The frequency of cardiac events in nicorandil-treated patients was compared with those in nontreated patients. Eighty-four patients received nicorandil during surgery and 237 patients received standard care. Cardiac events in the nicorandil-treated group occurred less frequently both during the operation (odds ratio, 0.15; 95% confidence interval, 0.03-0.76; P = 0.02) and after it (odds ratio, 0.24; 95% confidence interval, 0.06-0.90; P = 0.04). Conclusions Nicorandil reduces the frequency of cardiac events in patients undergoing noncardiac surgery, both during and after the operation.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/j.jclinane.2006.05.023</identifier><identifier>PMID: 17321926</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Anesthesia ; Anesthesia & Perioperative Care ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Angina pectoris ; Angioplasty ; Biological and medical sciences ; Blood pressure ; Cardiovascular Diseases - prevention & control ; Coronary vessels ; Diabetes ; Epidemiologic Methods ; Female ; Gender ; Heart attacks ; Heart failure ; Heart surgery ; Humans ; Intraoperative Complications - drug therapy ; Intraoperative Complications - prevention & control ; Ischemia ; Ischemic heart disease ; Japan ; Male ; Medical personnel ; Medical sciences ; Middle Aged ; Multicenter study ; Nicorandil ; Nicorandil - therapeutic use ; Noncardiac surgery ; Ostomy ; Pain Medicine ; Perioperative cardiac complications ; Postoperative Complications - drug therapy ; Postoperative Complications - prevention & control ; Surgical Procedures, Operative ; Treatment Outcome ; Vascular surgery ; Vasodilator Agents - therapeutic use</subject><ispartof>Journal of clinical anesthesia, 2007-02, Vol.19 (1), p.44-48</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-24a9e9c909feb71663de838401b34fa5ee20eec9b5ee349af67c866bdde1d1d23</citedby><cites>FETCH-LOGICAL-c479t-24a9e9c909feb71663de838401b34fa5ee20eec9b5ee349af67c866bdde1d1d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1034978103?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18611217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17321926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kashimoto, Satoshi, MD</creatorcontrib><creatorcontrib>Seki, Makoto, MD</creatorcontrib><creatorcontrib>Ishiguro, Toshihiko, MD</creatorcontrib><creatorcontrib>Yoshioka, Hitoshi, MD</creatorcontrib><creatorcontrib>Nagata, Osamu, MD</creatorcontrib><creatorcontrib>Nishimura, Kinya, MD</creatorcontrib><creatorcontrib>Kikuchi, Toshihiro, MD</creatorcontrib><creatorcontrib>Yamada, Tatsuya, MD</creatorcontrib><creatorcontrib>Iwade, Motoyo, MD</creatorcontrib><creatorcontrib>Omi, Akibumi, MD</creatorcontrib><creatorcontrib>Honda, Osamu, MD</creatorcontrib><creatorcontrib>Sakamoto, Atsuhiro, MD</creatorcontrib><creatorcontrib>Ogihara, Yukihiko, MD</creatorcontrib><creatorcontrib>Fujimoto, Keiko, MD</creatorcontrib><creatorcontrib>Nakaigawa, Yasushi, MD</creatorcontrib><creatorcontrib>Kato, Jitsu, MD</creatorcontrib><creatorcontrib>Watanabe, Akio, MD</creatorcontrib><creatorcontrib>Nomura, Minoru, MD</creatorcontrib><creatorcontrib>Takeda, Junzo, MD</creatorcontrib><title>Nicorandil decreases cardiac events during and after noncardiac surgery</title><title>Journal of clinical anesthesia</title><addtitle>J Clin Anesth</addtitle><description>Abstract Study Objective To assess whether nicorandil reduces the likelihood of cardiac events during and after intermediate risk surgery. Design Multicenter study. Setting 13 hospitals in Japan. Patients Intermediate-risk patients were identified by the presence of risk factors such as angina, a history of myocardial infarction, heart failure, diabetes mellitus, and abnormal electrocardiography (ECG). Interventions Nicorandil was given to these patients during the operation. Measurements and Main Results Cardiac events during the operation and the following 5 days were monitored. The frequency of cardiac events in nicorandil-treated patients was compared with those in nontreated patients. Eighty-four patients received nicorandil during surgery and 237 patients received standard care. Cardiac events in the nicorandil-treated group occurred less frequently both during the operation (odds ratio, 0.15; 95% confidence interval, 0.03-0.76; P = 0.02) and after it (odds ratio, 0.24; 95% confidence interval, 0.06-0.90; P = 0.04). Conclusions Nicorandil reduces the frequency of cardiac events in patients undergoing noncardiac surgery, both during and after the operation.</description><subject>Aged</subject><subject>Anesthesia</subject><subject>Anesthesia & Perioperative Care</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Angina pectoris</subject><subject>Angioplasty</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Gender</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Intraoperative Complications - drug therapy</subject><subject>Intraoperative Complications - prevention & control</subject><subject>Ischemia</subject><subject>Ischemic heart disease</subject><subject>Japan</subject><subject>Male</subject><subject>Medical personnel</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multicenter study</subject><subject>Nicorandil</subject><subject>Nicorandil - therapeutic use</subject><subject>Noncardiac surgery</subject><subject>Ostomy</subject><subject>Pain Medicine</subject><subject>Perioperative cardiac complications</subject><subject>Postoperative Complications - drug therapy</subject><subject>Postoperative Complications - prevention & control</subject><subject>Surgical Procedures, Operative</subject><subject>Treatment Outcome</subject><subject>Vascular surgery</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0952-8180</issn><issn>1873-4529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFksFq3DAQhkVpababvkIwlPZmdyTZsnUpDaFNCyE5tDkLWRoHuV47lezAvn3H7IaFXHoagb75NfMhxi44FBy4-twXvRvCaEcsBIAqoCpAyFdsw5ta5mUl9Gu2AV2JvOENnLF3KfUAQBf8LTvjtRRcC7Vh17fBTdGOPgyZRxfRJkyZs9EH6zJ8wnFOmV9iGB8yojLbzRizcRqfkbTEB4z7c_ams0PC98e6Zfffv_2--pHf3F3_vLq8yV1Z6zkXpdWonQbdYVtzpaTHRjYl8FaWna0QBSA63dJJltp2qnaNUq33yD33Qm7Zp0PuY5z-LphmswvJ4TCQiWlJpgZBW5eSwA8vwH5a4kizGQ4UXTdUiFIHysUppYideYxhZ-OeILOKNr15Fm1W0QYqQ6Kp8eIYv7Q79Ke2o1kCPh4Bm5wdOnLsQjpxjeJcEL1lXw8ckrWngNEkF3B06ENENxs_hf_P8uVFxEoFevUP7jGd9jZJGDC_1m-x_gpQAEIpIf8BQvez7Q</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Kashimoto, Satoshi, MD</creator><creator>Seki, Makoto, MD</creator><creator>Ishiguro, Toshihiko, MD</creator><creator>Yoshioka, Hitoshi, MD</creator><creator>Nagata, Osamu, MD</creator><creator>Nishimura, Kinya, MD</creator><creator>Kikuchi, Toshihiro, MD</creator><creator>Yamada, Tatsuya, MD</creator><creator>Iwade, Motoyo, MD</creator><creator>Omi, Akibumi, MD</creator><creator>Honda, Osamu, MD</creator><creator>Sakamoto, Atsuhiro, MD</creator><creator>Ogihara, Yukihiko, MD</creator><creator>Fujimoto, Keiko, MD</creator><creator>Nakaigawa, Yasushi, MD</creator><creator>Kato, Jitsu, MD</creator><creator>Watanabe, Akio, MD</creator><creator>Nomura, Minoru, MD</creator><creator>Takeda, Junzo, MD</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Nicorandil decreases cardiac events during and after noncardiac surgery</title><author>Kashimoto, Satoshi, MD ; Seki, Makoto, MD ; Ishiguro, Toshihiko, MD ; Yoshioka, Hitoshi, MD ; Nagata, Osamu, MD ; Nishimura, Kinya, MD ; Kikuchi, Toshihiro, MD ; Yamada, Tatsuya, MD ; Iwade, Motoyo, MD ; Omi, Akibumi, MD ; Honda, Osamu, MD ; Sakamoto, Atsuhiro, MD ; Ogihara, Yukihiko, MD ; Fujimoto, Keiko, MD ; Nakaigawa, Yasushi, MD ; Kato, Jitsu, MD ; Watanabe, Akio, MD ; Nomura, Minoru, MD ; Takeda, Junzo, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-24a9e9c909feb71663de838401b34fa5ee20eec9b5ee349af67c866bdde1d1d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Anesthesia</topic><topic>Anesthesia & Perioperative Care</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Angina pectoris</topic><topic>Angioplasty</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Gender</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Intraoperative Complications - drug therapy</topic><topic>Intraoperative Complications - prevention & control</topic><topic>Ischemia</topic><topic>Ischemic heart disease</topic><topic>Japan</topic><topic>Male</topic><topic>Medical personnel</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multicenter study</topic><topic>Nicorandil</topic><topic>Nicorandil - therapeutic use</topic><topic>Noncardiac surgery</topic><topic>Ostomy</topic><topic>Pain Medicine</topic><topic>Perioperative cardiac complications</topic><topic>Postoperative Complications - drug therapy</topic><topic>Postoperative Complications - prevention & control</topic><topic>Surgical Procedures, Operative</topic><topic>Treatment Outcome</topic><topic>Vascular surgery</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashimoto, Satoshi, MD</creatorcontrib><creatorcontrib>Seki, Makoto, MD</creatorcontrib><creatorcontrib>Ishiguro, Toshihiko, MD</creatorcontrib><creatorcontrib>Yoshioka, Hitoshi, MD</creatorcontrib><creatorcontrib>Nagata, Osamu, MD</creatorcontrib><creatorcontrib>Nishimura, Kinya, MD</creatorcontrib><creatorcontrib>Kikuchi, Toshihiro, MD</creatorcontrib><creatorcontrib>Yamada, Tatsuya, MD</creatorcontrib><creatorcontrib>Iwade, Motoyo, MD</creatorcontrib><creatorcontrib>Omi, Akibumi, MD</creatorcontrib><creatorcontrib>Honda, Osamu, MD</creatorcontrib><creatorcontrib>Sakamoto, Atsuhiro, MD</creatorcontrib><creatorcontrib>Ogihara, Yukihiko, MD</creatorcontrib><creatorcontrib>Fujimoto, Keiko, MD</creatorcontrib><creatorcontrib>Nakaigawa, Yasushi, MD</creatorcontrib><creatorcontrib>Kato, Jitsu, MD</creatorcontrib><creatorcontrib>Watanabe, Akio, MD</creatorcontrib><creatorcontrib>Nomura, Minoru, MD</creatorcontrib><creatorcontrib>Takeda, Junzo, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kashimoto, Satoshi, MD</au><au>Seki, Makoto, MD</au><au>Ishiguro, Toshihiko, MD</au><au>Yoshioka, Hitoshi, MD</au><au>Nagata, Osamu, MD</au><au>Nishimura, Kinya, MD</au><au>Kikuchi, Toshihiro, MD</au><au>Yamada, Tatsuya, MD</au><au>Iwade, Motoyo, MD</au><au>Omi, Akibumi, MD</au><au>Honda, Osamu, MD</au><au>Sakamoto, Atsuhiro, MD</au><au>Ogihara, Yukihiko, MD</au><au>Fujimoto, Keiko, MD</au><au>Nakaigawa, Yasushi, MD</au><au>Kato, Jitsu, MD</au><au>Watanabe, Akio, MD</au><au>Nomura, Minoru, MD</au><au>Takeda, Junzo, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicorandil decreases cardiac events during and after noncardiac surgery</atitle><jtitle>Journal of clinical anesthesia</jtitle><addtitle>J Clin Anesth</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>19</volume><issue>1</issue><spage>44</spage><epage>48</epage><pages>44-48</pages><issn>0952-8180</issn><eissn>1873-4529</eissn><abstract>Abstract Study Objective To assess whether nicorandil reduces the likelihood of cardiac events during and after intermediate risk surgery. Design Multicenter study. Setting 13 hospitals in Japan. Patients Intermediate-risk patients were identified by the presence of risk factors such as angina, a history of myocardial infarction, heart failure, diabetes mellitus, and abnormal electrocardiography (ECG). Interventions Nicorandil was given to these patients during the operation. Measurements and Main Results Cardiac events during the operation and the following 5 days were monitored. The frequency of cardiac events in nicorandil-treated patients was compared with those in nontreated patients. Eighty-four patients received nicorandil during surgery and 237 patients received standard care. Cardiac events in the nicorandil-treated group occurred less frequently both during the operation (odds ratio, 0.15; 95% confidence interval, 0.03-0.76; P = 0.02) and after it (odds ratio, 0.24; 95% confidence interval, 0.06-0.90; P = 0.04). Conclusions Nicorandil reduces the frequency of cardiac events in patients undergoing noncardiac surgery, both during and after the operation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17321926</pmid><doi>10.1016/j.jclinane.2006.05.023</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Anesthesia Anesthesia & Perioperative Care Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angina pectoris Angioplasty Biological and medical sciences Blood pressure Cardiovascular Diseases - prevention & control Coronary vessels Diabetes Epidemiologic Methods Female Gender Heart attacks Heart failure Heart surgery Humans Intraoperative Complications - drug therapy Intraoperative Complications - prevention & control Ischemia Ischemic heart disease Japan Male Medical personnel Medical sciences Middle Aged Multicenter study Nicorandil Nicorandil - therapeutic use Noncardiac surgery Ostomy Pain Medicine Perioperative cardiac complications Postoperative Complications - drug therapy Postoperative Complications - prevention & control Surgical Procedures, Operative Treatment Outcome Vascular surgery Vasodilator Agents - therapeutic use |
| title | Nicorandil decreases cardiac events during and after noncardiac surgery |
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