DeltaF508 mutation results in impaired gastric acid secretion

The cystic fibrosis transmembrane conductance regulator (CFTR) is recognized as a multifunctional protein that is involved in Cl(-) secretion, as well as acting as a regulatory protein. In order for acid secretion to take place a complex interaction of transport proteins and channels must occur at t...

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Veröffentlicht in:	The Journal of biological chemistry 2007-03, Vol.282 (9), p.6068-6074
Hauptverfasser:	Sidani, Shafik M, Kirchhoff, Philipp, Socrates, Thenral, Stelter, Lars, Ferreira, Elisa, Caputo, Christina, Roberts, Kurt E, Bell, Robert L, Egan, Marie E, Geibel, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters - analysis Cystic Fibrosis Transmembrane Conductance Regulator - physiology Gastric Acid - metabolism Gastric Mucosa - metabolism Mice Mice, Mutant Strains Mice, Transgenic Mutation Potassium Channels - analysis Potassium Channels, Inwardly Rectifying - analysis Receptors, Drug - analysis Stomach Sulfonylurea Receptors
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