Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2-Related Factor 2 (Nrf2)-Regulated Stress Pathway
The transcription factor nuclear factor erythroid-derived 2-related factor 2 (Nrf2) regulates induction of an extensive cellular stress response network when complexed with the cAMP-responsive element binding protein (CBP) at antioxidant response elements (ARE) located in the promoter region of targ...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2008-01, Vol.68 (2), p.364-368 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | BROWN, Stephan L SEKHAR, Konjeti R RACHAKONDA, Girish SASI, Soumya FREEMAN, Michael L |
| description | The transcription factor nuclear factor erythroid-derived 2-related factor 2 (Nrf2) regulates induction of an extensive cellular stress response network when complexed with the cAMP-responsive element binding protein (CBP) at antioxidant response elements (ARE) located in the promoter region of target genes. Activating transcription factor 3 (ATF3) can repress Nrf2-mediated signaling in a manner that is not well understood. Here, we show that ATF3-mediated suppression is a consequence of direct ATF3-Nrf2 protein-protein interactions that result in displacement of CBP from the ARE. This work establishes ATF3 as a novel repressor of the Nrf2-directed stress response pathway. |
| doi_str_mv | 10.1158/0008-5472.CAN-07-2170 |
| format | Article |
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Drug treatments ; Protein Binding ; Repressor Proteins - metabolism ; Repressor Proteins - physiology ; Response Elements - drug effects ; RNA, Small Interfering - pharmacology ; Signal Transduction - genetics ; Stress, Physiological - genetics ; Transfection ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2008-01, Vol.68 (2), p.364-368</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-42b2b59507c3020d3a612fc8e208b55fedbf66929f764bc74390f04eb630cab53</citedby><cites>FETCH-LOGICAL-c466t-42b2b59507c3020d3a612fc8e208b55fedbf66929f764bc74390f04eb630cab53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3342,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20167073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18199529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BROWN, Stephan L</creatorcontrib><creatorcontrib>SEKHAR, Konjeti R</creatorcontrib><creatorcontrib>RACHAKONDA, Girish</creatorcontrib><creatorcontrib>SASI, Soumya</creatorcontrib><creatorcontrib>FREEMAN, Michael L</creatorcontrib><title>Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2-Related Factor 2 (Nrf2)-Regulated Stress Pathway</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>The transcription factor nuclear factor erythroid-derived 2-related factor 2 (Nrf2) regulates induction of an extensive cellular stress response network when complexed with the cAMP-responsive element binding protein (CBP) at antioxidant response elements (ARE) located in the promoter region of target genes. Activating transcription factor 3 (ATF3) can repress Nrf2-mediated signaling in a manner that is not well understood. Here, we show that ATF3-mediated suppression is a consequence of direct ATF3-Nrf2 protein-protein interactions that result in displacement of CBP from the ARE. This work establishes ATF3 as a novel repressor of the Nrf2-directed stress response pathway.</description><subject>Activating Transcription Factor 3 - antagonists & inhibitors</subject><subject>Activating Transcription Factor 3 - genetics</subject><subject>Activating Transcription Factor 3 - metabolism</subject><subject>Activating Transcription Factor 3 - physiology</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Gene Expression Regulation</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>NF-E2-Related Factor 2 - antagonists & inhibitors</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>NF-E2-Related Factor 2 - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Binding</subject><subject>Repressor Proteins - metabolism</subject><subject>Repressor Proteins - physiology</subject><subject>Response Elements - drug effects</subject><subject>RNA, Small Interfering - pharmacology</subject><subject>Signal Transduction - genetics</subject><subject>Stress, Physiological - genetics</subject><subject>Transfection</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uEzEQhy0EoqHwCCBfQHDYMv639h6j0EKlKqBSzpbXazdGm2xqe4PyGLwxXmUpR04ez3zzm8OH0GsCF4QI9REAVCW4pBer5boCWVEi4QlaEMFUJTkXT9HikTlDL1L6Wb6CgHiOzogiTSNos0C_lzaHg8lhd4_votklG8M-h2GHr4zNQ8QMXyds8Ho4uB7fun10KZX24HHeOLwebe9M_AtfxmPexCF01ScXw8F1mFa3rje5VDNC8ft19PRD6d-Pp8n3PIXibyZvfpnjS_TMmz65V_N7jn5cXd6tvlQ3Xz9fr5Y3leV1nStOW9qKRoC0DCh0zNSEeqscBdUK4V3X-rpuaONlzVsrOWvAA3dtzcCaVrBz9O6Uu4_Dw-hS1tuQrOt7s3PDmLQsqYpQ8l-QgmCcKVVAcQJtHFKKzut9DFsTj5qAnqTpSYiehOgiTYPUk7Sy92Y-MLZb1_3bmi0V4O0MmGRN74snG9IjR4HUEiRjfwDbb584</recordid><startdate>20080115</startdate><enddate>20080115</enddate><creator>BROWN, Stephan L</creator><creator>SEKHAR, Konjeti R</creator><creator>RACHAKONDA, Girish</creator><creator>SASI, Soumya</creator><creator>FREEMAN, Michael L</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20080115</creationdate><title>Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2-Related Factor 2 (Nrf2)-Regulated Stress Pathway</title><author>BROWN, Stephan L ; SEKHAR, Konjeti R ; RACHAKONDA, Girish ; SASI, Soumya ; FREEMAN, Michael L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-42b2b59507c3020d3a612fc8e208b55fedbf66929f764bc74390f04eb630cab53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Activating Transcription Factor 3 - antagonists & inhibitors</topic><topic>Activating Transcription Factor 3 - genetics</topic><topic>Activating Transcription Factor 3 - metabolism</topic><topic>Activating Transcription Factor 3 - physiology</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Gene Expression Regulation</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>NF-E2-Related Factor 2 - antagonists & inhibitors</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>NF-E2-Related Factor 2 - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Binding</topic><topic>Repressor Proteins - metabolism</topic><topic>Repressor Proteins - physiology</topic><topic>Response Elements - drug effects</topic><topic>RNA, Small Interfering - pharmacology</topic><topic>Signal Transduction - genetics</topic><topic>Stress, Physiological - genetics</topic><topic>Transfection</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BROWN, Stephan L</creatorcontrib><creatorcontrib>SEKHAR, Konjeti R</creatorcontrib><creatorcontrib>RACHAKONDA, Girish</creatorcontrib><creatorcontrib>SASI, Soumya</creatorcontrib><creatorcontrib>FREEMAN, Michael L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BROWN, Stephan L</au><au>SEKHAR, Konjeti R</au><au>RACHAKONDA, Girish</au><au>SASI, Soumya</au><au>FREEMAN, Michael L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2-Related Factor 2 (Nrf2)-Regulated Stress Pathway</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2008-01-15</date><risdate>2008</risdate><volume>68</volume><issue>2</issue><spage>364</spage><epage>368</epage><pages>364-368</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>The transcription factor nuclear factor erythroid-derived 2-related factor 2 (Nrf2) regulates induction of an extensive cellular stress response network when complexed with the cAMP-responsive element binding protein (CBP) at antioxidant response elements (ARE) located in the promoter region of target genes. Activating transcription factor 3 (ATF3) can repress Nrf2-mediated signaling in a manner that is not well understood. Here, we show that ATF3-mediated suppression is a consequence of direct ATF3-Nrf2 protein-protein interactions that result in displacement of CBP from the ARE. This work establishes ATF3 as a novel repressor of the Nrf2-directed stress response pathway.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>18199529</pmid><doi>10.1158/0008-5472.CAN-07-2170</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 2008-01, Vol.68 (2), p.364-368 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Activating Transcription Factor 3 - antagonists & inhibitors Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism Activating Transcription Factor 3 - physiology Animals Antineoplastic agents Antioxidants - pharmacology Biological and medical sciences Cells, Cultured Gene Expression Regulation Medical sciences Mice NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - metabolism NF-E2-Related Factor 2 - physiology Pharmacology. Drug treatments Protein Binding Repressor Proteins - metabolism Repressor Proteins - physiology Response Elements - drug effects RNA, Small Interfering - pharmacology Signal Transduction - genetics Stress, Physiological - genetics Transfection Tumors |
| title | Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2-Related Factor 2 (Nrf2)-Regulated Stress Pathway |
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