Seven Years’ Experience with 5-Aminolevulinic Acid in Detection of Transitional Cell Carcinoma of the Bladder
Objectives Photodynamic diagnosis (PDD) using 5-aminolevulinic acid has proved to be a procedure with an outstanding sensitivity for the detection of transitional cell carcinoma of the bladder, in particular in the detection of flat urothelial lesions. We report on our clinical results with 875 pati...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2007-02, Vol.69 (2), p.260-264 |
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| creator | Hungerhuber, Edwin Stepp, Herbert Kriegmair, Martin Stief, Christian Hofstetter, Alfons Hartmann, Arndt Knuechel, Ruth Karl, Alexander Tritschler, Stefan Zaak, Dirk |
| description | Objectives Photodynamic diagnosis (PDD) using 5-aminolevulinic acid has proved to be a procedure with an outstanding sensitivity for the detection of transitional cell carcinoma of the bladder, in particular in the detection of flat urothelial lesions. We report on our clinical results with 875 patients (1713 PDD procedures) between March 1995 and March 2002. Methods A total of 1713 PDD procedures were done in 875 patients. Fluorescence imaging was performed 2 to 3 hours after instillation of 50 mL of a 3% solution of 5-aminolevulinic acid into the bladder by an incoherent light source. In total, specimens from 4630 lesions (2.7 lesions/PDD) were taken. Results In 34.8% of all biopsies, the histologic finding was malignant; 23.7% of these biopsies had been taken only because of positive fluorescence. In 28.5% of the positive biopsies, flat lesions had been identified. Also, 43.4% of carcinoma in situ and 30.7% of dysplasia II° were detected only by positive fluorescence. Of all tumor lesions, 92.0% were detected by PDD compared with 76.3% detected by white light endoscopy. Conclusions PDD has proved to be an effective detection device for superficial bladder cancer. |
| doi_str_mv | 10.1016/j.urology.2006.10.015 |
| format | Article |
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We report on our clinical results with 875 patients (1713 PDD procedures) between March 1995 and March 2002. Methods A total of 1713 PDD procedures were done in 875 patients. Fluorescence imaging was performed 2 to 3 hours after instillation of 50 mL of a 3% solution of 5-aminolevulinic acid into the bladder by an incoherent light source. In total, specimens from 4630 lesions (2.7 lesions/PDD) were taken. Results In 34.8% of all biopsies, the histologic finding was malignant; 23.7% of these biopsies had been taken only because of positive fluorescence. In 28.5% of the positive biopsies, flat lesions had been identified. Also, 43.4% of carcinoma in situ and 30.7% of dysplasia II° were detected only by positive fluorescence. Of all tumor lesions, 92.0% were detected by PDD compared with 76.3% detected by white light endoscopy. Conclusions PDD has proved to be an effective detection device for superficial bladder cancer.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/j.urology.2006.10.015</identifier><identifier>PMID: 17320660</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Intravesical ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aminolevulinic Acid ; Biological and medical sciences ; Carcinoma, Transitional Cell - diagnosis ; Carcinoma, Transitional Cell - surgery ; Cohort Studies ; Cystoscopy - methods ; Female ; Fluorescence ; Humans ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Photosensitizing Agents ; Retrospective Studies ; Risk Assessment ; Sensitivity and Specificity ; Tumors of the urinary system ; Urinary Bladder Neoplasms - diagnosis ; Urinary Bladder Neoplasms - surgery ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland ; Urology</subject><ispartof>Urology (Ridgewood, N.J.), 2007-02, Vol.69 (2), p.260-264</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-a0e69960c47c0b65ddcd28539dbeea2300afbf66b8ece41d1db25d60262eff823</citedby><cites>FETCH-LOGICAL-c448t-a0e69960c47c0b65ddcd28539dbeea2300afbf66b8ece41d1db25d60262eff823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.urology.2006.10.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18565324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17320660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hungerhuber, Edwin</creatorcontrib><creatorcontrib>Stepp, Herbert</creatorcontrib><creatorcontrib>Kriegmair, Martin</creatorcontrib><creatorcontrib>Stief, Christian</creatorcontrib><creatorcontrib>Hofstetter, Alfons</creatorcontrib><creatorcontrib>Hartmann, Arndt</creatorcontrib><creatorcontrib>Knuechel, Ruth</creatorcontrib><creatorcontrib>Karl, Alexander</creatorcontrib><creatorcontrib>Tritschler, Stefan</creatorcontrib><creatorcontrib>Zaak, Dirk</creatorcontrib><title>Seven Years’ Experience with 5-Aminolevulinic Acid in Detection of Transitional Cell Carcinoma of the Bladder</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>Objectives Photodynamic diagnosis (PDD) using 5-aminolevulinic acid has proved to be a procedure with an outstanding sensitivity for the detection of transitional cell carcinoma of the bladder, in particular in the detection of flat urothelial lesions. We report on our clinical results with 875 patients (1713 PDD procedures) between March 1995 and March 2002. Methods A total of 1713 PDD procedures were done in 875 patients. Fluorescence imaging was performed 2 to 3 hours after instillation of 50 mL of a 3% solution of 5-aminolevulinic acid into the bladder by an incoherent light source. In total, specimens from 4630 lesions (2.7 lesions/PDD) were taken. Results In 34.8% of all biopsies, the histologic finding was malignant; 23.7% of these biopsies had been taken only because of positive fluorescence. In 28.5% of the positive biopsies, flat lesions had been identified. Also, 43.4% of carcinoma in situ and 30.7% of dysplasia II° were detected only by positive fluorescence. Of all tumor lesions, 92.0% were detected by PDD compared with 76.3% detected by white light endoscopy. Conclusions PDD has proved to be an effective detection device for superficial bladder cancer.</description><subject>Administration, Intravesical</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aminolevulinic Acid</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Transitional Cell - diagnosis</subject><subject>Carcinoma, Transitional Cell - surgery</subject><subject>Cohort Studies</subject><subject>Cystoscopy - methods</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Photosensitizing Agents</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Sensitivity and Specificity</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder Neoplasms - diagnosis</subject><subject>Urinary Bladder Neoplasms - surgery</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><subject>Urology</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkr2O1DAQgC0E4paDRwC5gS7L2ImdpAEty_EjnURxR0FlOfaE85LEi50sbMdr8Ho8Cc5tpJNoaPz7jT36Zgh5ymDNgMmXu_UUfOe_HtccQKazNTBxj6yY4GVW17W4T1YANWQFr8UZeRTjDhIoZfmQnLEy52kNK-Kv8IAD_YI6xD-_ftOLn3sMDgeD9Icbb6jINr0bfIeHqXODM3RjnKVuoG9xRDM6P1Df0uugh-jmne7oFrs06GBSXK_n6_EG6ZtOW4vhMXnQ6i7ik2U-J5_fXVxvP2SXn95_3G4uM1MU1ZhpQFnXEkxRGmiksNZYXom8tg2i5jmAbptWyqZCgwWzzDZcWAlccmzbiufn5MXp3X3w3yeMo-pdNCkzPaCfoiqBQ8lEnUBxAk3wMQZs1T64XoejYqBm02qnFtNqNj0fJ9Mp7tnywdT0aO-iFrUJeL4AOhrdtUmRcfGOq4QUOS8S9_rEYdJxcBhUNLcFsC4kw8p6999UXv3zgrmtle6-4RHjzk8h1SUqpiJXoK7mtpi7ApKvXHCW_wX71rYG</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Hungerhuber, Edwin</creator><creator>Stepp, Herbert</creator><creator>Kriegmair, Martin</creator><creator>Stief, Christian</creator><creator>Hofstetter, Alfons</creator><creator>Hartmann, Arndt</creator><creator>Knuechel, Ruth</creator><creator>Karl, Alexander</creator><creator>Tritschler, Stefan</creator><creator>Zaak, Dirk</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Seven Years’ Experience with 5-Aminolevulinic Acid in Detection of Transitional Cell Carcinoma of the Bladder</title><author>Hungerhuber, Edwin ; Stepp, Herbert ; Kriegmair, Martin ; Stief, Christian ; Hofstetter, Alfons ; Hartmann, Arndt ; Knuechel, Ruth ; Karl, Alexander ; Tritschler, Stefan ; Zaak, Dirk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-a0e69960c47c0b65ddcd28539dbeea2300afbf66b8ece41d1db25d60262eff823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Administration, Intravesical</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aminolevulinic Acid</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Transitional Cell - diagnosis</topic><topic>Carcinoma, Transitional Cell - surgery</topic><topic>Cohort Studies</topic><topic>Cystoscopy - methods</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Photosensitizing Agents</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Sensitivity and Specificity</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder Neoplasms - diagnosis</topic><topic>Urinary Bladder Neoplasms - surgery</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hungerhuber, Edwin</creatorcontrib><creatorcontrib>Stepp, Herbert</creatorcontrib><creatorcontrib>Kriegmair, Martin</creatorcontrib><creatorcontrib>Stief, Christian</creatorcontrib><creatorcontrib>Hofstetter, Alfons</creatorcontrib><creatorcontrib>Hartmann, Arndt</creatorcontrib><creatorcontrib>Knuechel, Ruth</creatorcontrib><creatorcontrib>Karl, Alexander</creatorcontrib><creatorcontrib>Tritschler, Stefan</creatorcontrib><creatorcontrib>Zaak, Dirk</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hungerhuber, Edwin</au><au>Stepp, Herbert</au><au>Kriegmair, Martin</au><au>Stief, Christian</au><au>Hofstetter, Alfons</au><au>Hartmann, Arndt</au><au>Knuechel, Ruth</au><au>Karl, Alexander</au><au>Tritschler, Stefan</au><au>Zaak, Dirk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seven Years’ Experience with 5-Aminolevulinic Acid in Detection of Transitional Cell Carcinoma of the Bladder</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>69</volume><issue>2</issue><spage>260</spage><epage>264</epage><pages>260-264</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>Objectives Photodynamic diagnosis (PDD) using 5-aminolevulinic acid has proved to be a procedure with an outstanding sensitivity for the detection of transitional cell carcinoma of the bladder, in particular in the detection of flat urothelial lesions. We report on our clinical results with 875 patients (1713 PDD procedures) between March 1995 and March 2002. Methods A total of 1713 PDD procedures were done in 875 patients. Fluorescence imaging was performed 2 to 3 hours after instillation of 50 mL of a 3% solution of 5-aminolevulinic acid into the bladder by an incoherent light source. In total, specimens from 4630 lesions (2.7 lesions/PDD) were taken. Results In 34.8% of all biopsies, the histologic finding was malignant; 23.7% of these biopsies had been taken only because of positive fluorescence. In 28.5% of the positive biopsies, flat lesions had been identified. Also, 43.4% of carcinoma in situ and 30.7% of dysplasia II° were detected only by positive fluorescence. Of all tumor lesions, 92.0% were detected by PDD compared with 76.3% detected by white light endoscopy. Conclusions PDD has proved to be an effective detection device for superficial bladder cancer.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17320660</pmid><doi>10.1016/j.urology.2006.10.015</doi><tpages>5</tpages></addata></record> |
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| subjects | Administration, Intravesical Adolescent Adult Aged Aged, 80 and over Aminolevulinic Acid Biological and medical sciences Carcinoma, Transitional Cell - diagnosis Carcinoma, Transitional Cell - surgery Cohort Studies Cystoscopy - methods Female Fluorescence Humans Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Photosensitizing Agents Retrospective Studies Risk Assessment Sensitivity and Specificity Tumors of the urinary system Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - surgery Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Urology |
| title | Seven Years’ Experience with 5-Aminolevulinic Acid in Detection of Transitional Cell Carcinoma of the Bladder |
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