Isolation and characterization of degradation impurities in docetaxel drug substance and its formulation

The degradation of docetaxel drug substance and its injection formulation has been investigated. The majority of impurities were observed in a base degradation study and all five degradation products were characterized. These impurities were isolated, enriched and were subjected to mass and NMR spec...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2007-03, Vol.43 (4), p.1228-1235
Hauptverfasser:	Kumar, Dinesh, Tomar, Rajesh Singh, Deolia, Santosh Kumar, Mitra, Moloy, Mukherjee, Rama, Burman, Anand C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Antineoplastic Agents - analysis Antineoplastic Agents - chemistry Biological and medical sciences Characterization Chromatography Chromatography, High Pressure Liquid Degradation impurity Docetaxel Drug Contamination Fundamental and applied biological sciences. Psychology General pharmacology HPLC Identification Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Molecular Structure Pharmacology. Drug treatments Spectroscopy Taxoids - analysis Taxoids - chemistry
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