EXERCISE PERFORMANCE AND VENTILATORY EFFICIENCY IN PATIENTS WITH MILD AND MODERATE LIVER CIRRHOSIS
SUMMARY 1 The impact of ventilatory efficiency on reduced exercise capacity and recovery oxygen kinetics has not been addressed in cirrhotic patients. The aim of the present study was to investigate exercise performance and ventilatory efficiency in patients with mild and moderate liver cirrhosis (L...
Gespeichert in:
| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 2008-02, Vol.35 (2), p.135-140 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 140 |
|---|---|
| container_issue | 2 |
| container_start_page | 135 |
| container_title | Clinical and experimental pharmacology & physiology |
| container_volume | 35 |
| creator | Terziyski, K Andonov, V Marinov, B Kostianev, S |
| description | SUMMARY
1
The impact of ventilatory efficiency on reduced exercise capacity and recovery oxygen kinetics has not been addressed in cirrhotic patients. The aim of the present study was to investigate exercise performance and ventilatory efficiency in patients with mild and moderate liver cirrhosis (LC).
2
Nineteen male non‐hypoxic patients with LC (age 51.3 ± 9.1 years; body mass index (BMI) 25.6 ± 3.6 kg/m2) classified by the Child‐Pugh score as class A (n = 7) and class B (n = 12) and 19 age‐ and BMI‐matched controls participated in the study. Subjects undertook maximal incremental exercise testing on a treadmill using the Bruce protocol.
3
Patients with LC showed a reduced diffusion capacity (DL,CO%) compared with controls (74.6 ± 15.2 vs 95.6 ± 12.9%, respectively; P |
| doi_str_mv | 10.1111/j.1440-1681.2007.04751.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70207050</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70207050</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4051-d0be481bd110ae68fe6a5e0ee16ee669c8deb641bf6697235c4b7bbb3b646ab43</originalsourceid><addsrcrecordid>eNqNkM9v2jAUx62p1cra_QuVT7sle84P2xx6iIIBVyFBSdquJysORoJBYXHR6H9fp6DuOl_e8_P38yx9EMIEfOLOz7VPogg8QjnxAwDmQ8Ri4h-_oMHnwwUaQAixRziDK_TN2jUAxEDDr-iKcDJkfEgGSItfokxlJfBclOOinCV5KnCSj_CjyGuZJXVRPmMxHstUijx9xjLH86R2fV3hJ1lP8Uxmow9gVoxEmdQCZ_JRlDiVZTktKlndoMtls7Hm-7leo4exqNOplxUTmSaZ10YQE28B2kSc6AUh0BjKl4Y2sQFjCDWG0mHLF0bTiOilu7AgjNtIM6116Ia00VF4jX6c9u673Z-Dsa9qu7Kt2WyaF7M7WMUgAOYMuCA_BdtuZ21nlmrfrbZN96YIqN6vWqteo-o1qt6v-vCrjg69Pf9x0Fuz-AeehbrA3Snwd7Uxb_-9WKVi3neO9078yr6a4yffdL8VZSGL1VM-UfeTILgPeKVo-A6eeo-2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70207050</pqid></control><display><type>article</type><title>EXERCISE PERFORMANCE AND VENTILATORY EFFICIENCY IN PATIENTS WITH MILD AND MODERATE LIVER CIRRHOSIS</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Terziyski, K ; Andonov, V ; Marinov, B ; Kostianev, S</creator><creatorcontrib>Terziyski, K ; Andonov, V ; Marinov, B ; Kostianev, S</creatorcontrib><description>SUMMARY
1
The impact of ventilatory efficiency on reduced exercise capacity and recovery oxygen kinetics has not been addressed in cirrhotic patients. The aim of the present study was to investigate exercise performance and ventilatory efficiency in patients with mild and moderate liver cirrhosis (LC).
2
Nineteen male non‐hypoxic patients with LC (age 51.3 ± 9.1 years; body mass index (BMI) 25.6 ± 3.6 kg/m2) classified by the Child‐Pugh score as class A (n = 7) and class B (n = 12) and 19 age‐ and BMI‐matched controls participated in the study. Subjects undertook maximal incremental exercise testing on a treadmill using the Bruce protocol.
3
Patients with LC showed a reduced diffusion capacity (DL,CO%) compared with controls (74.6 ± 15.2 vs 95.6 ± 12.9%, respectively; P < 0.001), but a comparable volume standardized diffusion coefficient (1.33 ± 0.22 vs 1.45 ± 0.18 mmol/min per kPa per L, respectively; P = 0.74). Patients with LC had a significantly lower exercise capacity compared with controls (VO2max 23.8 ± 3.8 vs 30.6 ± 4.4 mL/min per kg, respectively; P < 0.001). Recovery oxygen kinetics were also impaired in LC patients compared with controls (104.6 ± 19.3 vs 84.4 ± 22.7 s, respectively; P = 0.012). The chronotropic index was significantly lower in the LC group compared with controls (0.67 ± 0.19 vs 0.82 ± 0.17, respectively; P = 0.030) and LC patients showed higher ventilatory equivalents (30.4 ± 3.8 vs 26.3 ± 2.3, respectively; P < 0.001) and lower oxygen uptake efficiency slope values (2187 ± 445 vs 2745 ± 473 mL/min per log10L, respectively; P < 0.001) compared with controls, which is indicative of decreased ventilatory efficiency. Patients with LC also had a higher standardized maximal exercise perception score (SMEPS) compared with controls (0.62 ± 0.18 vs 0.46 ± 0.15, respectively; P = 0.011). Moderate negative correlations were found between Child‐Pugh score and VO2max% (r = –0.496; P = 0.031).
4
In conclusion, patients with mild and moderate LC have reduced exercise capacity, which correlates with Child‐Pugh score, as well as reduced chronotropic index and prolonged recovery oxygen uptake kinetics. The results suggest worsened ventilatory efficiency during exercise and cardiopulmonary reasons for the higher SMEPS in these patients.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.2007.04751.x</identifier><identifier>PMID: 18197891</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adult ; Case-Control Studies ; exercise ; Exercise Test ; Exercise Tolerance ; Humans ; Kinetics ; Liver Cirrhosis - physiopathology ; Male ; Middle Aged ; Oxygen Consumption ; oxygen uptake efficiency slope ; perceived exertion ; Pulmonary Diffusing Capacity ; Pulmonary Gas Exchange ; Pulmonary Ventilation ; recovery oxygen kinetics ; Severity of Illness Index ; Spirometry ; time constant</subject><ispartof>Clinical and experimental pharmacology & physiology, 2008-02, Vol.35 (2), p.135-140</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4051-d0be481bd110ae68fe6a5e0ee16ee669c8deb641bf6697235c4b7bbb3b646ab43</citedby><cites>FETCH-LOGICAL-c4051-d0be481bd110ae68fe6a5e0ee16ee669c8deb641bf6697235c4b7bbb3b646ab43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.2007.04751.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.2007.04751.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18197891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terziyski, K</creatorcontrib><creatorcontrib>Andonov, V</creatorcontrib><creatorcontrib>Marinov, B</creatorcontrib><creatorcontrib>Kostianev, S</creatorcontrib><title>EXERCISE PERFORMANCE AND VENTILATORY EFFICIENCY IN PATIENTS WITH MILD AND MODERATE LIVER CIRRHOSIS</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1
The impact of ventilatory efficiency on reduced exercise capacity and recovery oxygen kinetics has not been addressed in cirrhotic patients. The aim of the present study was to investigate exercise performance and ventilatory efficiency in patients with mild and moderate liver cirrhosis (LC).
2
Nineteen male non‐hypoxic patients with LC (age 51.3 ± 9.1 years; body mass index (BMI) 25.6 ± 3.6 kg/m2) classified by the Child‐Pugh score as class A (n = 7) and class B (n = 12) and 19 age‐ and BMI‐matched controls participated in the study. Subjects undertook maximal incremental exercise testing on a treadmill using the Bruce protocol.
3
Patients with LC showed a reduced diffusion capacity (DL,CO%) compared with controls (74.6 ± 15.2 vs 95.6 ± 12.9%, respectively; P < 0.001), but a comparable volume standardized diffusion coefficient (1.33 ± 0.22 vs 1.45 ± 0.18 mmol/min per kPa per L, respectively; P = 0.74). Patients with LC had a significantly lower exercise capacity compared with controls (VO2max 23.8 ± 3.8 vs 30.6 ± 4.4 mL/min per kg, respectively; P < 0.001). Recovery oxygen kinetics were also impaired in LC patients compared with controls (104.6 ± 19.3 vs 84.4 ± 22.7 s, respectively; P = 0.012). The chronotropic index was significantly lower in the LC group compared with controls (0.67 ± 0.19 vs 0.82 ± 0.17, respectively; P = 0.030) and LC patients showed higher ventilatory equivalents (30.4 ± 3.8 vs 26.3 ± 2.3, respectively; P < 0.001) and lower oxygen uptake efficiency slope values (2187 ± 445 vs 2745 ± 473 mL/min per log10L, respectively; P < 0.001) compared with controls, which is indicative of decreased ventilatory efficiency. Patients with LC also had a higher standardized maximal exercise perception score (SMEPS) compared with controls (0.62 ± 0.18 vs 0.46 ± 0.15, respectively; P = 0.011). Moderate negative correlations were found between Child‐Pugh score and VO2max% (r = –0.496; P = 0.031).
4
In conclusion, patients with mild and moderate LC have reduced exercise capacity, which correlates with Child‐Pugh score, as well as reduced chronotropic index and prolonged recovery oxygen uptake kinetics. The results suggest worsened ventilatory efficiency during exercise and cardiopulmonary reasons for the higher SMEPS in these patients.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>exercise</subject><subject>Exercise Test</subject><subject>Exercise Tolerance</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen Consumption</subject><subject>oxygen uptake efficiency slope</subject><subject>perceived exertion</subject><subject>Pulmonary Diffusing Capacity</subject><subject>Pulmonary Gas Exchange</subject><subject>Pulmonary Ventilation</subject><subject>recovery oxygen kinetics</subject><subject>Severity of Illness Index</subject><subject>Spirometry</subject><subject>time constant</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9v2jAUx62p1cra_QuVT7sle84P2xx6iIIBVyFBSdquJysORoJBYXHR6H9fp6DuOl_e8_P38yx9EMIEfOLOz7VPogg8QjnxAwDmQ8Ri4h-_oMHnwwUaQAixRziDK_TN2jUAxEDDr-iKcDJkfEgGSItfokxlJfBclOOinCV5KnCSj_CjyGuZJXVRPmMxHstUijx9xjLH86R2fV3hJ1lP8Uxmow9gVoxEmdQCZ_JRlDiVZTktKlndoMtls7Hm-7leo4exqNOplxUTmSaZ10YQE28B2kSc6AUh0BjKl4Y2sQFjCDWG0mHLF0bTiOilu7AgjNtIM6116Ia00VF4jX6c9u673Z-Dsa9qu7Kt2WyaF7M7WMUgAOYMuCA_BdtuZ21nlmrfrbZN96YIqN6vWqteo-o1qt6v-vCrjg69Pf9x0Fuz-AeehbrA3Snwd7Uxb_-9WKVi3neO9078yr6a4yffdL8VZSGL1VM-UfeTILgPeKVo-A6eeo-2</recordid><startdate>200802</startdate><enddate>200802</enddate><creator>Terziyski, K</creator><creator>Andonov, V</creator><creator>Marinov, B</creator><creator>Kostianev, S</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200802</creationdate><title>EXERCISE PERFORMANCE AND VENTILATORY EFFICIENCY IN PATIENTS WITH MILD AND MODERATE LIVER CIRRHOSIS</title><author>Terziyski, K ; Andonov, V ; Marinov, B ; Kostianev, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4051-d0be481bd110ae68fe6a5e0ee16ee669c8deb641bf6697235c4b7bbb3b646ab43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>exercise</topic><topic>Exercise Test</topic><topic>Exercise Tolerance</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen Consumption</topic><topic>oxygen uptake efficiency slope</topic><topic>perceived exertion</topic><topic>Pulmonary Diffusing Capacity</topic><topic>Pulmonary Gas Exchange</topic><topic>Pulmonary Ventilation</topic><topic>recovery oxygen kinetics</topic><topic>Severity of Illness Index</topic><topic>Spirometry</topic><topic>time constant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terziyski, K</creatorcontrib><creatorcontrib>Andonov, V</creatorcontrib><creatorcontrib>Marinov, B</creatorcontrib><creatorcontrib>Kostianev, S</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terziyski, K</au><au>Andonov, V</au><au>Marinov, B</au><au>Kostianev, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EXERCISE PERFORMANCE AND VENTILATORY EFFICIENCY IN PATIENTS WITH MILD AND MODERATE LIVER CIRRHOSIS</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2008-02</date><risdate>2008</risdate><volume>35</volume><issue>2</issue><spage>135</spage><epage>140</epage><pages>135-140</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1
The impact of ventilatory efficiency on reduced exercise capacity and recovery oxygen kinetics has not been addressed in cirrhotic patients. The aim of the present study was to investigate exercise performance and ventilatory efficiency in patients with mild and moderate liver cirrhosis (LC).
2
Nineteen male non‐hypoxic patients with LC (age 51.3 ± 9.1 years; body mass index (BMI) 25.6 ± 3.6 kg/m2) classified by the Child‐Pugh score as class A (n = 7) and class B (n = 12) and 19 age‐ and BMI‐matched controls participated in the study. Subjects undertook maximal incremental exercise testing on a treadmill using the Bruce protocol.
3
Patients with LC showed a reduced diffusion capacity (DL,CO%) compared with controls (74.6 ± 15.2 vs 95.6 ± 12.9%, respectively; P < 0.001), but a comparable volume standardized diffusion coefficient (1.33 ± 0.22 vs 1.45 ± 0.18 mmol/min per kPa per L, respectively; P = 0.74). Patients with LC had a significantly lower exercise capacity compared with controls (VO2max 23.8 ± 3.8 vs 30.6 ± 4.4 mL/min per kg, respectively; P < 0.001). Recovery oxygen kinetics were also impaired in LC patients compared with controls (104.6 ± 19.3 vs 84.4 ± 22.7 s, respectively; P = 0.012). The chronotropic index was significantly lower in the LC group compared with controls (0.67 ± 0.19 vs 0.82 ± 0.17, respectively; P = 0.030) and LC patients showed higher ventilatory equivalents (30.4 ± 3.8 vs 26.3 ± 2.3, respectively; P < 0.001) and lower oxygen uptake efficiency slope values (2187 ± 445 vs 2745 ± 473 mL/min per log10L, respectively; P < 0.001) compared with controls, which is indicative of decreased ventilatory efficiency. Patients with LC also had a higher standardized maximal exercise perception score (SMEPS) compared with controls (0.62 ± 0.18 vs 0.46 ± 0.15, respectively; P = 0.011). Moderate negative correlations were found between Child‐Pugh score and VO2max% (r = –0.496; P = 0.031).
4
In conclusion, patients with mild and moderate LC have reduced exercise capacity, which correlates with Child‐Pugh score, as well as reduced chronotropic index and prolonged recovery oxygen uptake kinetics. The results suggest worsened ventilatory efficiency during exercise and cardiopulmonary reasons for the higher SMEPS in these patients.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>18197891</pmid><doi>10.1111/j.1440-1681.2007.04751.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-1870 |
| ispartof | Clinical and experimental pharmacology & physiology, 2008-02, Vol.35 (2), p.135-140 |
| issn | 0305-1870 1440-1681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70207050 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Case-Control Studies exercise Exercise Test Exercise Tolerance Humans Kinetics Liver Cirrhosis - physiopathology Male Middle Aged Oxygen Consumption oxygen uptake efficiency slope perceived exertion Pulmonary Diffusing Capacity Pulmonary Gas Exchange Pulmonary Ventilation recovery oxygen kinetics Severity of Illness Index Spirometry time constant |
| title | EXERCISE PERFORMANCE AND VENTILATORY EFFICIENCY IN PATIENTS WITH MILD AND MODERATE LIVER CIRRHOSIS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T12%3A02%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=EXERCISE%20PERFORMANCE%20AND%20VENTILATORY%20EFFICIENCY%20IN%20PATIENTS%20WITH%20MILD%20AND%20MODERATE%20LIVER%20CIRRHOSIS&rft.jtitle=Clinical%20and%20experimental%20pharmacology%20&%20physiology&rft.au=Terziyski,%20K&rft.date=2008-02&rft.volume=35&rft.issue=2&rft.spage=135&rft.epage=140&rft.pages=135-140&rft.issn=0305-1870&rft.eissn=1440-1681&rft_id=info:doi/10.1111/j.1440-1681.2007.04751.x&rft_dat=%3Cproquest_cross%3E70207050%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70207050&rft_id=info:pmid/18197891&rfr_iscdi=true |