Structural Studies of the Alzheimer’s Amyloid Precursor Protein Copper-binding Domain Reveal How it Binds Copper Ions

Alzheimer's disease (AD) is the major cause of dementia. Amyloid β peptide (Aβ), generated by proteolytic cleavage of the amyloid precursor protein (APP), is central to AD pathogenesis. APP can function as a metalloprotein and modulate copper (Cu) transport, presumably via its extracellular Cu-...

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Veröffentlicht in:	J. Mol. Biol 2007-03, Vol.367 (1), p.148-161
Hauptverfasser:	Kong, Geoffrey K.-W., Adams, Julian J., Harris, Hugh H., Boas, John F., Curtain, Cyril C., Galatis, Denise, Masters, Colin L., Barnham, Kevin J., McKinstry, William J., Cappai, Roberto, Parker, Michael W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Copper - chemistry Copper - metabolism copper-binding protein Crystallography electron paramagnetic resonance Protein Conformation Protein Structure, Tertiary X-ray absorption spectroscopy
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