Design and Synthesis of Cyclic RGD Pentapeptoids by Consecutive Ugi Reactions
A new strategy for the synthesis of cyclic peptoids was developed. The approach is based on the use of consecutive Ugi reactions for the assembly of the acyclic peptoid and for the ring closure. Cyclopentapeptoid analogues of the RGD peptides were designed and synthesized using this methodology. The...
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| Veröffentlicht in: | Organic letters 2008-01, Vol.10 (2), p.205-208 |
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| container_title | Organic letters |
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| creator | Vercillo, Otilie E Andrade, Carlos Kleber Z Wessjohann, Ludger A |
| description | A new strategy for the synthesis of cyclic peptoids was developed. The approach is based on the use of consecutive Ugi reactions for the assembly of the acyclic peptoid and for the ring closure. Cyclopentapeptoid analogues of the RGD peptides were designed and synthesized using this methodology. The results confirm the versatility and efficiency of the method for the preparation of cyclic oligopeptoids. |
| doi_str_mv | 10.1021/ol702521g |
| format | Article |
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The approach is based on the use of consecutive Ugi reactions for the assembly of the acyclic peptoid and for the ring closure. Cyclopentapeptoid analogues of the RGD peptides were designed and synthesized using this methodology. 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Lett</addtitle><description>A new strategy for the synthesis of cyclic peptoids was developed. The approach is based on the use of consecutive Ugi reactions for the assembly of the acyclic peptoid and for the ring closure. Cyclopentapeptoid analogues of the RGD peptides were designed and synthesized using this methodology. 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| ispartof | Organic letters, 2008-01, Vol.10 (2), p.205-208 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70204922 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Cyclization Models, Molecular Molecular Structure Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptoids - chemical synthesis Peptoids - chemistry |
| title | Design and Synthesis of Cyclic RGD Pentapeptoids by Consecutive Ugi Reactions |
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