Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche

Mesenchymal stem cells (MSC) establish close interactions with bone marrow sinusoids in a putative perivascular niche. These vessels contain a large storage pool of mature nonproliferating neutrophils. Here, we have investigated the effects of human bone marrow MSC on neutrophil survival and effecto...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2008-01, Vol.26 (1), p.151-162
Hauptverfasser:	Raffaghello, Lizzia, Bianchi, Giordano, Bertolotto, Maria, Montecucco, Fabrizio, Busca, Alessandro, Dallegri, Franco, Ottonello, Luciano, Pistoia, Vito
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Blotting, Western Bone Marrow Bone Marrow Cells - metabolism Cell Adhesion - physiology Cell Communication - physiology Cell Movement - physiology Flow Cytometry Humans Image Processing, Computer-Assisted Immunohistochemistry Interleukin-6 - metabolism Interleukin-8 - metabolism Interleukin‐6R/Interleukin‐6 fusion protein Mesenchymal stem cells Mesenchymal Stromal Cells - metabolism N-Formylmethionine Leucyl-Phenylalanine - metabolism Neutrophils Neutrophils - metabolism Reverse Transcriptase Polymerase Chain Reaction STAT3 Transcription Factor - physiology
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