Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11beta-hydroxysteroid dehydrogenase type 2

Although rat is the most widely used model of glucocorticoid programming of the fetus, the role of rat placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in the transplacental pharmacokinetics of the naturally occurring glucocorticoid, corticosterone, has not yet been fully elucidate...

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Veröffentlicht in:	Placenta (Eastbourne) 2006-02, Vol.27 (2-3), p.171-180
Hauptverfasser:	Staud, F, Mazancová, K, Miksík, I, Pávek, P, Fendrich, Z, Pácha, J
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 2 - antagonists & inhibitors 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism Animals Biological Transport Carbenoxolone - pharmacology Corticosterone - metabolism Female In Vitro Techniques Perfusion Placenta - enzymology Placenta - metabolism Placenta - physiology Pregnancy - metabolism Rats
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