Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR(mRen-2)27 rats
Abstract To establish the effect of dietary ω -3 PUFA on angiotensin II (ANG II)-mediated hypertension, male TGR (mRen-2)27 (Ren-2) rats (animals with high ANG II activity) were maintained on a diet either deficient or sufficient in ω -3 PUFA from conception. Half the animals on each diet were treat...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2008-01, Vol.78 (1), p.67-72 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Jayasooriya, A.P Begg, D.P Chen, N Mathai, M.L Sinclair, A.J Wilkinson-Berka, J Wark, J.D Weisinger, H.S Weisinger, R.S |
| description | Abstract To establish the effect of dietary ω -3 PUFA on angiotensin II (ANG II)-mediated hypertension, male TGR (mRen-2)27 (Ren-2) rats (animals with high ANG II activity) were maintained on a diet either deficient or sufficient in ω -3 PUFA from conception. Half the animals on each diet were treated with the angiotensin-converting enzyme inhibitor, perindopril, from birth. Ren-2 rats fed the ω -3 PUFA deficient diet were significantly more hypertensive than those fed the ω -3 PUFA sufficient diet. Perindopril reduced the blood pressure of both ω -3 PUFA-deficient and ω -3 PUFA-sufficient diet-fed Ren-2 rats. Body weight, body fat and plasma leptin were reduced by perindopril treatment but not affected by ω -3 PUFA supply. Given that the elevated blood pressure of the Ren-2 rat is mediated by ANG II, the data suggest that ω -3 PUFA may reduce hypertension via the renin–angiotensin system. |
| doi_str_mv | 10.1016/j.plefa.2007.11.001 |
| format | Article |
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Half the animals on each diet were treated with the angiotensin-converting enzyme inhibitor, perindopril, from birth. Ren-2 rats fed the ω -3 PUFA deficient diet were significantly more hypertensive than those fed the ω -3 PUFA sufficient diet. Perindopril reduced the blood pressure of both ω -3 PUFA-deficient and ω -3 PUFA-sufficient diet-fed Ren-2 rats. Body weight, body fat and plasma leptin were reduced by perindopril treatment but not affected by ω -3 PUFA supply. Given that the elevated blood pressure of the Ren-2 rat is mediated by ANG II, the data suggest that ω -3 PUFA may reduce hypertension via the renin–angiotensin system.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/j.plefa.2007.11.001</identifier><identifier>PMID: 18083506</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adipose Tissue - drug effects ; Advanced Basic Science ; Angiotensin II - blood ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Animals ; Antihypertensive Agents - pharmacology ; Antihypertensive Agents - therapeutic use ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Body Weight - drug effects ; Cardiology. Vascular system ; Eating - drug effects ; Endocrinology & Metabolism ; Experimental diseases ; Fatty Acids, Omega-3 - administration & dosage ; Fundamental and applied biological sciences. 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Half the animals on each diet were treated with the angiotensin-converting enzyme inhibitor, perindopril, from birth. Ren-2 rats fed the ω -3 PUFA deficient diet were significantly more hypertensive than those fed the ω -3 PUFA sufficient diet. Perindopril reduced the blood pressure of both ω -3 PUFA-deficient and ω -3 PUFA-sufficient diet-fed Ren-2 rats. Body weight, body fat and plasma leptin were reduced by perindopril treatment but not affected by ω -3 PUFA supply. Given that the elevated blood pressure of the Ren-2 rat is mediated by ANG II, the data suggest that ω -3 PUFA may reduce hypertension via the renin–angiotensin system.</description><subject>Adipose Tissue - drug effects</subject><subject>Advanced Basic Science</subject><subject>Angiotensin II - blood</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Eating - drug effects</subject><subject>Endocrinology & Metabolism</subject><subject>Experimental diseases</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypertension - blood</subject><subject>Hypertension - diet therapy</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Perindopril - therapeutic use</subject><subject>Rats</subject><subject>Renin - blood</subject><subject>Vertebrates: endocrinology</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2L1TAUhoMoznX0FwjSjaKLXs9J-pEuFGTQURgYGMelhDQ91VzbtJOkQv-9qfei4MZVIDzve8JzwthThD0CVq8P-3mgXu85QL1H3APgPbbDUvCcSy7usx00Jc8Fr-UZexTCAQA4YvGQnaEEKUqoduzr9UjfdC6yeRrWxQUdF68jdVmvY1wzbWyXhWVOk0ZyUUc7ucxTtxgK2fd1Jh_Jhe3Suuz28ubleEMu5694naWa8Jg96PUQ6MnpPGdfPry_vfiYX11ffrp4d5WbouAxN11JTQWiErIoqxaLrq2kaEzTtkWrTdVJQ1obLpsWNq7sq5QzKLFsTcFRnLMXx97ZT3cLhahGGwwNg3Y0LUHVwKHgskygOILGTyF46tXs7aj9qhDUZlUd1G-rarOqEFWymlLPTvVLO1L3N3PSmIDnJ0AHo4fea2ds-MOlLg418sS9OXKUZPy05FUwlpyhznoyUXWT_c9D3v6TN4N1No38QSuFw7R4lzwrVIErUJ-3D7DtH-qUrutG_ALP9Kqm</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Jayasooriya, A.P</creator><creator>Begg, D.P</creator><creator>Chen, N</creator><creator>Mathai, M.L</creator><creator>Sinclair, A.J</creator><creator>Wilkinson-Berka, J</creator><creator>Wark, J.D</creator><creator>Weisinger, H.S</creator><creator>Weisinger, R.S</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR(mRen-2)27 rats</title><author>Jayasooriya, A.P ; Begg, D.P ; Chen, N ; Mathai, M.L ; Sinclair, A.J ; Wilkinson-Berka, J ; Wark, J.D ; Weisinger, H.S ; Weisinger, R.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-cd5e9603638456b14db6839c9bb4bac6d8ceaac289b096035f6442c1815bc4213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adipose Tissue - drug effects</topic><topic>Advanced Basic Science</topic><topic>Angiotensin II - blood</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Animals</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Eating - drug effects</topic><topic>Endocrinology & Metabolism</topic><topic>Experimental diseases</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fundamental and applied biological sciences. 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| subjects | Adipose Tissue - drug effects Advanced Basic Science Angiotensin II - blood Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Body Weight - drug effects Cardiology. Vascular system Eating - drug effects Endocrinology & Metabolism Experimental diseases Fatty Acids, Omega-3 - administration & dosage Fundamental and applied biological sciences. Psychology Hypertension - blood Hypertension - diet therapy Hypertension - drug therapy Hypertension - therapy Male Medical sciences Perindopril - therapeutic use Rats Renin - blood Vertebrates: endocrinology |
| title | Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR(mRen-2)27 rats |
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