Chronic morphine exposure during puberty induces long-lasting changes in opioid-related mRNA expression in the mediobasal hypothalamus

Abstract Substance abuse in developing females may have significant long-term effects on reproductive competency. Chronic morphine exposure during puberty has been shown to reduce prolactin secretion in lactating rats. Opioid activity within the mediobasal hypothalamus (MBH) regulates suckling-induc...

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Veröffentlicht in:	Brain research 2008-01, Vol.1190, p.186-192
1. Verfasser:	Byrnes, Elizabeth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Drug abuse Drug Administration Schedule Estrous Cycle - metabolism Female Hypothalamus, Middle - drug effects Hypothalamus, Middle - metabolism Kappa opioid receptor Lactation - metabolism Male Morphine - administration & dosage Morphine - pharmacology Mu opioid receptor Narcotics - administration & dosage Narcotics - pharmacology Neurology Opiates POMC Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Prolactin Prolactin - metabolism Rats Receptors, Opioid, kappa - genetics Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - genetics Receptors, Opioid, mu - metabolism Reproduction - physiology RNA, Messenger - analysis Sexual Maturation - drug effects Sexual Maturation - physiology
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