CCR1 Acts Downstream of NFAT2 in Osteoclastogenesis and Enhances Cell Migration

We found that a chemokine receptor gene, CCR1, acts downstream of NFAT2 in RANKL‐stimulated RAW264 and bone marrow cells. The upstream regulatory region of CCR1 showed RANKL‐dependent and CsA‐suppressible promoter activity. Downregulation of the expression and function of CCR1 suppressed cell migrat...

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Veröffentlicht in:	Journal of bone and mineral research 2006-01, Vol.21 (1), p.48-57
Hauptverfasser:	Ishida, Norihiro, Hayashi, Koji, Hattori, Asuka, Yogo, Keiichiro, Kimura, Toru, Takeya, Tatsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences bone marrow cells Bone Marrow Cells - cytology Bone Marrow Cells - metabolism CCR1 Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line cell migration Cell Movement - drug effects Cell Movement - physiology Cyclosporine - pharmacology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Mice NFAT2 NFATC Transcription Factors - metabolism Osteoclasts - cytology Osteoclasts - metabolism Pertussis Toxin - pharmacology RAW264 cells Receptors, CCR1 Receptors, Chemokine - metabolism RNA, Small Interfering - pharmacology Signal Transduction - drug effects Signal Transduction - physiology Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
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