Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling
Contraction-induced production of reactive oxygen species has been shown to cause oxidative stress to skeletal muscle. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise. Nuclear factor κB and mitogen-activated protein kinase are two major oxidative-s...
Gespeichert in:
| Veröffentlicht in: | Free radical biology & medicine 2008-01, Vol.44 (2), p.142-152 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 152 |
|---|---|
| container_issue | 2 |
| container_start_page | 142 |
| container_title | Free radical biology & medicine |
| container_volume | 44 |
| creator | Ji, Li Li |
| description | Contraction-induced production of reactive oxygen species has been shown to cause oxidative stress to skeletal muscle. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise. Nuclear factor κB and mitogen-activated protein kinase are two major oxidative-stress-sensitive signal transduction pathways that have been shown to activate the gene expression of a number of enzymes and proteins that play important roles in maintenance of intracellular oxidant–antioxidant homeostasis. This mini-review will discuss the main mechanisms and gene targets for these signaling pathways during exercise and the biological significance of the adaptation. |
| doi_str_mv | 10.1016/j.freeradbiomed.2007.02.031 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70199767</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0891584907001839</els_id><sourcerecordid>70199767</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-f95c3f6cf8d11530ad93cd78634a220f2533ed142fb9369d3e867340387070793</originalsourceid><addsrcrecordid>eNqNkEFr3DAQhUVoSDbb_IUgKPRmZ2TZltSeSkibQEIgpL0KrTQK2nqtVLLD5t9Xyy6F3sIc3uG9N8N8hHxiUDNg_eW69gkxGbcKcYOubgBEDU0NnB2RBZOCV22n-g9kAVKxqpOtOiVnOa8BoO24PCGnTDLFRAcL8us-unkwU4gjjZ7m3zjgZAa6mbMdkJqxONvgilKHHseMdPVGcYvJhoxf6GMsqVJM6OKW5vA8miGMzx_JsTdDxvODLsnP79dPVzfV3cOP26tvd5VtWzFVXnWW-9566RjrOBinuHVC9rw1TQO-6ThHx9rGrxTvleMoe8Fb4FJAGcWX5PN-70uKf2bMk96EbHEYzIhxzloAU0qUzpJ83Qdtijkn9PolhY1Jb5qB3mHVa_0fVr3DqqHRBWtpXxzOzKud96974FgC1_sAlmdfAyadbcDRogsJ7aRdDO869BfRA5Cs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70199767</pqid></control><display><type>article</type><title>Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ji, Li Li</creator><creatorcontrib>Ji, Li Li</creatorcontrib><description>Contraction-induced production of reactive oxygen species has been shown to cause oxidative stress to skeletal muscle. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise. Nuclear factor κB and mitogen-activated protein kinase are two major oxidative-stress-sensitive signal transduction pathways that have been shown to activate the gene expression of a number of enzymes and proteins that play important roles in maintenance of intracellular oxidant–antioxidant homeostasis. This mini-review will discuss the main mechanisms and gene targets for these signaling pathways during exercise and the biological significance of the adaptation.</description><identifier>ISSN: 0891-5849</identifier><identifier>EISSN: 1873-4596</identifier><identifier>DOI: 10.1016/j.freeradbiomed.2007.02.031</identifier><identifier>PMID: 18191750</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adaptation, Physiological - genetics ; Adaptation, Physiological - physiology ; Aging - genetics ; Aging - physiology ; Animals ; Antioxidant ; Antioxidants - metabolism ; Antioxidants - physiology ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - physiology ; Exercise ; Exercise - physiology ; Gene Expression Regulation, Enzymologic ; Glutathione Peroxidase - genetics ; Glutathione Peroxidase - physiology ; Humans ; Inflammation Mediators - metabolism ; Inflammation Mediators - physiology ; MAPK ; Mitogen-Activated Protein Kinase Kinases - genetics ; Mitogen-Activated Protein Kinase Kinases - physiology ; Models, Biological ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiology ; NF-kappa B - genetics ; NF-kappa B - physiology ; NFκB ; Nitric Oxide Synthase Type II - genetics ; Nitric Oxide Synthase Type II - physiology ; Oxidation-Reduction ; Physical Conditioning, Animal - physiology ; Reactive oxygen species ; Signal Transduction - genetics ; Signal Transduction - physiology ; Signaling ; Superoxide Dismutase - genetics ; Superoxide Dismutase - physiology ; Transcription Factor AP-1 - genetics ; Transcription Factor AP-1 - physiology</subject><ispartof>Free radical biology & medicine, 2008-01, Vol.44 (2), p.142-152</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-f95c3f6cf8d11530ad93cd78634a220f2533ed142fb9369d3e867340387070793</citedby><cites>FETCH-LOGICAL-c447t-f95c3f6cf8d11530ad93cd78634a220f2533ed142fb9369d3e867340387070793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0891584907001839$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18191750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ji, Li Li</creatorcontrib><title>Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling</title><title>Free radical biology & medicine</title><addtitle>Free Radic Biol Med</addtitle><description>Contraction-induced production of reactive oxygen species has been shown to cause oxidative stress to skeletal muscle. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise. Nuclear factor κB and mitogen-activated protein kinase are two major oxidative-stress-sensitive signal transduction pathways that have been shown to activate the gene expression of a number of enzymes and proteins that play important roles in maintenance of intracellular oxidant–antioxidant homeostasis. This mini-review will discuss the main mechanisms and gene targets for these signaling pathways during exercise and the biological significance of the adaptation.</description><subject>Adaptation, Physiological - genetics</subject><subject>Adaptation, Physiological - physiology</subject><subject>Aging - genetics</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Antioxidant</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - physiology</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Glutathione Peroxidase - genetics</subject><subject>Glutathione Peroxidase - physiology</subject><subject>Humans</subject><subject>Inflammation Mediators - metabolism</subject><subject>Inflammation Mediators - physiology</subject><subject>MAPK</subject><subject>Mitogen-Activated Protein Kinase Kinases - genetics</subject><subject>Mitogen-Activated Protein Kinase Kinases - physiology</subject><subject>Models, Biological</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - physiology</subject><subject>NFκB</subject><subject>Nitric Oxide Synthase Type II - genetics</subject><subject>Nitric Oxide Synthase Type II - physiology</subject><subject>Oxidation-Reduction</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Reactive oxygen species</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - physiology</subject><subject>Signaling</subject><subject>Superoxide Dismutase - genetics</subject><subject>Superoxide Dismutase - physiology</subject><subject>Transcription Factor AP-1 - genetics</subject><subject>Transcription Factor AP-1 - physiology</subject><issn>0891-5849</issn><issn>1873-4596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFr3DAQhUVoSDbb_IUgKPRmZ2TZltSeSkibQEIgpL0KrTQK2nqtVLLD5t9Xyy6F3sIc3uG9N8N8hHxiUDNg_eW69gkxGbcKcYOubgBEDU0NnB2RBZOCV22n-g9kAVKxqpOtOiVnOa8BoO24PCGnTDLFRAcL8us-unkwU4gjjZ7m3zjgZAa6mbMdkJqxONvgilKHHseMdPVGcYvJhoxf6GMsqVJM6OKW5vA8miGMzx_JsTdDxvODLsnP79dPVzfV3cOP26tvd5VtWzFVXnWW-9566RjrOBinuHVC9rw1TQO-6ThHx9rGrxTvleMoe8Fb4FJAGcWX5PN-70uKf2bMk96EbHEYzIhxzloAU0qUzpJ83Qdtijkn9PolhY1Jb5qB3mHVa_0fVr3DqqHRBWtpXxzOzKud96974FgC1_sAlmdfAyadbcDRogsJ7aRdDO869BfRA5Cs</recordid><startdate>20080115</startdate><enddate>20080115</enddate><creator>Ji, Li Li</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080115</creationdate><title>Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling</title><author>Ji, Li Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-f95c3f6cf8d11530ad93cd78634a220f2533ed142fb9369d3e867340387070793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adaptation, Physiological - genetics</topic><topic>Adaptation, Physiological - physiology</topic><topic>Aging - genetics</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Antioxidant</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - physiology</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Adhesion Molecules - physiology</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Glutathione Peroxidase - genetics</topic><topic>Glutathione Peroxidase - physiology</topic><topic>Humans</topic><topic>Inflammation Mediators - metabolism</topic><topic>Inflammation Mediators - physiology</topic><topic>MAPK</topic><topic>Mitogen-Activated Protein Kinase Kinases - genetics</topic><topic>Mitogen-Activated Protein Kinase Kinases - physiology</topic><topic>Models, Biological</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>NF-kappa B - genetics</topic><topic>NF-kappa B - physiology</topic><topic>NFκB</topic><topic>Nitric Oxide Synthase Type II - genetics</topic><topic>Nitric Oxide Synthase Type II - physiology</topic><topic>Oxidation-Reduction</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Reactive oxygen species</topic><topic>Signal Transduction - genetics</topic><topic>Signal Transduction - physiology</topic><topic>Signaling</topic><topic>Superoxide Dismutase - genetics</topic><topic>Superoxide Dismutase - physiology</topic><topic>Transcription Factor AP-1 - genetics</topic><topic>Transcription Factor AP-1 - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ji, Li Li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Free radical biology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ji, Li Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling</atitle><jtitle>Free radical biology & medicine</jtitle><addtitle>Free Radic Biol Med</addtitle><date>2008-01-15</date><risdate>2008</risdate><volume>44</volume><issue>2</issue><spage>142</spage><epage>152</epage><pages>142-152</pages><issn>0891-5849</issn><eissn>1873-4596</eissn><abstract>Contraction-induced production of reactive oxygen species has been shown to cause oxidative stress to skeletal muscle. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise. Nuclear factor κB and mitogen-activated protein kinase are two major oxidative-stress-sensitive signal transduction pathways that have been shown to activate the gene expression of a number of enzymes and proteins that play important roles in maintenance of intracellular oxidant–antioxidant homeostasis. This mini-review will discuss the main mechanisms and gene targets for these signaling pathways during exercise and the biological significance of the adaptation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18191750</pmid><doi>10.1016/j.freeradbiomed.2007.02.031</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0891-5849 |
| ispartof | Free radical biology & medicine, 2008-01, Vol.44 (2), p.142-152 |
| issn | 0891-5849 1873-4596 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70199767 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adaptation, Physiological - genetics Adaptation, Physiological - physiology Aging - genetics Aging - physiology Animals Antioxidant Antioxidants - metabolism Antioxidants - physiology Cell Adhesion Molecules - genetics Cell Adhesion Molecules - physiology Exercise Exercise - physiology Gene Expression Regulation, Enzymologic Glutathione Peroxidase - genetics Glutathione Peroxidase - physiology Humans Inflammation Mediators - metabolism Inflammation Mediators - physiology MAPK Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - physiology Models, Biological Muscle, Skeletal - metabolism Muscle, Skeletal - physiology NF-kappa B - genetics NF-kappa B - physiology NFκB Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - physiology Oxidation-Reduction Physical Conditioning, Animal - physiology Reactive oxygen species Signal Transduction - genetics Signal Transduction - physiology Signaling Superoxide Dismutase - genetics Superoxide Dismutase - physiology Transcription Factor AP-1 - genetics Transcription Factor AP-1 - physiology |
| title | Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T21%3A13%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modulation%20of%20skeletal%20muscle%20antioxidant%20defense%20by%20exercise:%20Role%20of%20redox%20signaling&rft.jtitle=Free%20radical%20biology%20&%20medicine&rft.au=Ji,%20Li%20Li&rft.date=2008-01-15&rft.volume=44&rft.issue=2&rft.spage=142&rft.epage=152&rft.pages=142-152&rft.issn=0891-5849&rft.eissn=1873-4596&rft_id=info:doi/10.1016/j.freeradbiomed.2007.02.031&rft_dat=%3Cproquest_cross%3E70199767%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70199767&rft_id=info:pmid/18191750&rft_els_id=S0891584907001839&rfr_iscdi=true |