Active dimer of Epratuzumab provides insight into the complex nature of an antibody aggregate

Understanding the intermolecular products of antibodies as a consequence of host-cell expression, aging, and heat-stress can be insightful especially when it involves the development of a stable biopharmaceutical product. The dimerized form of Epratuzumab (an IgG1 antibody) with a molecular mass of...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2006-01, Vol.95 (1), p.126-145
Hauptverfasser:	Remmele, Richard L., Callahan, William J., Krishnan, Sampathkumar, Zhou, Linda, Bondarenko, Pavel V., Nichols, Andrew C., Kleemann, Gerd R., Pipes, Gary D., Park, Sungae, Fodor, Szilan, Kras, Eva, Brems, David N.
Format:	Artikel
Sprache:	eng
Schlagworte:	adduct Antibodies, Monoclonal - chemistry Antibodies, Monoclonal, Humanized Antineoplastic Agents - chemistry Biological and medical sciences Dimerization General pharmacology glycoprotein Medical sciences Papain - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments physical stability preformulation protein aggregation protein formulation protein structure solvation structure-activity relationship Temperature
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