Influence of PDE5 inhibitor on MRI measurement of clitoral volume response in women with FSAD: a feasibility study of a potential technique for evaluating drug response

The purpose of this study was to determine if magnetic resonance imaging (MRI) could quantify a difference in clitoral response following administration of a vasoactive medication, in 12 women with female sexual arousal disorder (FSAD). Subjects were entered into a double-blind, randomized two-way c...

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Veröffentlicht in:International journal of impotence research 2008-01, Vol.20 (1), p.105-110
Hauptverfasser: Yang, C C, Cao, Y Y, Guan, Q Y, Heiman, J R, Kuffel, S W, Peterson, B T, Maravilla, K R
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container_issue 1
container_start_page 105
container_title International journal of impotence research
container_volume 20
creator Yang, C C
Cao, Y Y
Guan, Q Y
Heiman, J R
Kuffel, S W
Peterson, B T
Maravilla, K R
description The purpose of this study was to determine if magnetic resonance imaging (MRI) could quantify a difference in clitoral response following administration of a vasoactive medication, in 12 women with female sexual arousal disorder (FSAD). Subjects were entered into a double-blind, randomized two-way crossover study of sildenafil 50 mg vs placebo administered 1 h prior to genital MRI. Each subject underwent two MR studies, performed while subjects viewed alternating segments of nonerotic and erotic video. MR images were analyzed for change in clitoral volume during each session. The mean change in clitoral volume for the entire group was higher in the sildenafil MRI session (1282 mm 3 ) compared with placebo (849 mm 3 ) but did not reach statistical significance ( P =0.064). Comparison using analysis of variance between the two sessions for each individual subject revealed a significant increase in clitoral volume following sildenafil compared with placebo in 6 of 12 subjects, no significant change in either imaging session in three subjects and in three subjects, there was a robust clitoral response in both MR sessions. In conclusion, MR measurements of clitoral volume can provide an objective measure of engorgement change following a vasoactive medication in women with FSAD.
doi_str_mv 10.1038/sj.ijir.3901625
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Subjects were entered into a double-blind, randomized two-way crossover study of sildenafil 50 mg vs placebo administered 1 h prior to genital MRI. Each subject underwent two MR studies, performed while subjects viewed alternating segments of nonerotic and erotic video. MR images were analyzed for change in clitoral volume during each session. The mean change in clitoral volume for the entire group was higher in the sildenafil MRI session (1282 mm 3 ) compared with placebo (849 mm 3 ) but did not reach statistical significance ( P =0.064). Comparison using analysis of variance between the two sessions for each individual subject revealed a significant increase in clitoral volume following sildenafil compared with placebo in 6 of 12 subjects, no significant change in either imaging session in three subjects and in three subjects, there was a robust clitoral response in both MR sessions. In conclusion, MR measurements of clitoral volume can provide an objective measure of engorgement change following a vasoactive medication in women with FSAD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18059502</pmid><doi>10.1038/sj.ijir.3901625</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Biological and medical sciences
Clitoris
Clitoris - drug effects
Clitoris - physiopathology
Diagnosis
Dosage and administration
Double-Blind Method
Drug therapy
Feasibility Studies
Female
Genital diseases, Female
Gynecology. Andrology. Obstetrics
Health aspects
Humans
Magnetic Resonance Imaging
Medical examination
Medical sciences
Medicine
Medicine & Public Health
original-article
Phosphodiesterase Inhibitors - pharmacology
Piperazines - pharmacology
Purines - pharmacology
Reproductive Medicine
rology
Sexual Dysfunctions, Psychological - drug therapy
Sildenafil
Sildenafil Citrate
Sulfones - pharmacology
Urology
Vasodilator Agents - pharmacology
title Influence of PDE5 inhibitor on MRI measurement of clitoral volume response in women with FSAD: a feasibility study of a potential technique for evaluating drug response
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