Influence of PDE5 inhibitor on MRI measurement of clitoral volume response in women with FSAD: a feasibility study of a potential technique for evaluating drug response
The purpose of this study was to determine if magnetic resonance imaging (MRI) could quantify a difference in clitoral response following administration of a vasoactive medication, in 12 women with female sexual arousal disorder (FSAD). Subjects were entered into a double-blind, randomized two-way c...
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Veröffentlicht in: | International journal of impotence research 2008-01, Vol.20 (1), p.105-110 |
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creator | Yang, C C Cao, Y Y Guan, Q Y Heiman, J R Kuffel, S W Peterson, B T Maravilla, K R |
description | The purpose of this study was to determine if magnetic resonance imaging (MRI) could quantify a difference in clitoral response following administration of a vasoactive medication, in 12 women with female sexual arousal disorder (FSAD). Subjects were entered into a double-blind, randomized two-way crossover study of sildenafil 50 mg vs placebo administered 1 h prior to genital MRI. Each subject underwent two MR studies, performed while subjects viewed alternating segments of nonerotic and erotic video. MR images were analyzed for change in clitoral volume during each session. The mean change in clitoral volume for the entire group was higher in the sildenafil MRI session (1282 mm
3
) compared with placebo (849 mm
3
) but did not reach statistical significance (
P
=0.064). Comparison using analysis of variance between the two sessions for each individual subject revealed a significant increase in clitoral volume following sildenafil compared with placebo in 6 of 12 subjects, no significant change in either imaging session in three subjects and in three subjects, there was a robust clitoral response in both MR sessions. In conclusion, MR measurements of clitoral volume can provide an objective measure of engorgement change following a vasoactive medication in women with FSAD. |
doi_str_mv | 10.1038/sj.ijir.3901625 |
format | Article |
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3
) compared with placebo (849 mm
3
) but did not reach statistical significance (
P
=0.064). Comparison using analysis of variance between the two sessions for each individual subject revealed a significant increase in clitoral volume following sildenafil compared with placebo in 6 of 12 subjects, no significant change in either imaging session in three subjects and in three subjects, there was a robust clitoral response in both MR sessions. In conclusion, MR measurements of clitoral volume can provide an objective measure of engorgement change following a vasoactive medication in women with FSAD.</description><identifier>ISSN: 0955-9930</identifier><identifier>EISSN: 1476-5489</identifier><identifier>DOI: 10.1038/sj.ijir.3901625</identifier><identifier>PMID: 18059502</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biological and medical sciences ; Clitoris ; Clitoris - drug effects ; Clitoris - physiopathology ; Diagnosis ; Dosage and administration ; Double-Blind Method ; Drug therapy ; Feasibility Studies ; Female ; Genital diseases, Female ; Gynecology. Andrology. Obstetrics ; Health aspects ; Humans ; Magnetic Resonance Imaging ; Medical examination ; Medical sciences ; Medicine ; Medicine & Public Health ; original-article ; Phosphodiesterase Inhibitors - pharmacology ; Piperazines - pharmacology ; Purines - pharmacology ; Reproductive Medicine ; rology ; Sexual Dysfunctions, Psychological - drug therapy ; Sildenafil ; Sildenafil Citrate ; Sulfones - pharmacology ; Urology ; Vasodilator Agents - pharmacology</subject><ispartof>International journal of impotence research, 2008-01, Vol.20 (1), p.105-110</ispartof><rights>Springer Nature Limited 2008</rights><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2008</rights><rights>Nature Publishing Group 2008.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c582t-99c5093b5607a58c72d2d49c1222549dba5b76b97ac8ce6645cc59756ee09ae83</citedby><cites>FETCH-LOGICAL-c582t-99c5093b5607a58c72d2d49c1222549dba5b76b97ac8ce6645cc59756ee09ae83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20110256$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18059502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, C C</creatorcontrib><creatorcontrib>Cao, Y Y</creatorcontrib><creatorcontrib>Guan, Q Y</creatorcontrib><creatorcontrib>Heiman, J R</creatorcontrib><creatorcontrib>Kuffel, S W</creatorcontrib><creatorcontrib>Peterson, B T</creatorcontrib><creatorcontrib>Maravilla, K R</creatorcontrib><title>Influence of PDE5 inhibitor on MRI measurement of clitoral volume response in women with FSAD: a feasibility study of a potential technique for evaluating drug response</title><title>International journal of impotence research</title><addtitle>Int J Impot Res</addtitle><addtitle>Int J Impot Res</addtitle><description>The purpose of this study was to determine if magnetic resonance imaging (MRI) could quantify a difference in clitoral response following administration of a vasoactive medication, in 12 women with female sexual arousal disorder (FSAD). Subjects were entered into a double-blind, randomized two-way crossover study of sildenafil 50 mg vs placebo administered 1 h prior to genital MRI. Each subject underwent two MR studies, performed while subjects viewed alternating segments of nonerotic and erotic video. MR images were analyzed for change in clitoral volume during each session. The mean change in clitoral volume for the entire group was higher in the sildenafil MRI session (1282 mm
3
) compared with placebo (849 mm
3
) but did not reach statistical significance (
P
=0.064). Comparison using analysis of variance between the two sessions for each individual subject revealed a significant increase in clitoral volume following sildenafil compared with placebo in 6 of 12 subjects, no significant change in either imaging session in three subjects and in three subjects, there was a robust clitoral response in both MR sessions. In conclusion, MR measurements of clitoral volume can provide an objective measure of engorgement change following a vasoactive medication in women with FSAD.</description><subject>Biological and medical sciences</subject><subject>Clitoris</subject><subject>Clitoris - drug effects</subject><subject>Clitoris - physiopathology</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Double-Blind Method</subject><subject>Drug therapy</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Genital diseases, Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical examination</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>original-article</subject><subject>Phosphodiesterase Inhibitors - pharmacology</subject><subject>Piperazines - pharmacology</subject><subject>Purines - pharmacology</subject><subject>Reproductive Medicine</subject><subject>rology</subject><subject>Sexual Dysfunctions, Psychological - drug therapy</subject><subject>Sildenafil</subject><subject>Sildenafil Citrate</subject><subject>Sulfones - pharmacology</subject><subject>Urology</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0955-9930</issn><issn>1476-5489</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kl1v0zAUhiMEYmVwzRXIAm137ewkjmPuqn1ApSEQH9eR45y0rhK72M6m_iN-5k7U0jHE5AtLPs_7nmP7TZLXjM4YzcqzsJ6ZtfGzTFJWpPxJMmG5KKY8L-XTZEIl51MpM3qUvAhhTSkdsefJESspl5ymk-T3wrbdAFYDcS35enHJibErU5voPHGWfP62ID2oMHjowcYR0t1YVB25cd3QA_EQNs4GQCG5dUiRWxNX5Or7_OIDUaRFNfqhaEtCHJrt6KHIxkX0M2gTQa-s-TUAabEn3KhuUNHYJWn8sDy4v0yetaoL8Gq_Hyc_ry5_nH-aXn_5uDifX081L9OIt9WcyqzmBRWKl1qkTdrkUrM0TXkum1rxWhS1FEqXGooi51pzKXgBQKWCMjtOTne-G-9wphCr3gQNXacsuCFUgjIp80wg-P4fcO0Gb3G2KkXbLMuFYEi9e5RiklJB8X8OVkvVQWVs66JXeuxbzRFilOVspGb_oXA10BvtLLQGzx8ITv8SrEB1cRXwz6LBB30Inu1A7V0IHtpq402v_LZitBpzVoV1Neas2ucMFW_31xrqHpp7fh8sBE72gApada1XVptw4FLKGE15gRzdcQFLdgn-_n0e7_1mJ7EqYiwPnn_qd5KD9IM</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Yang, C C</creator><creator>Cao, Y Y</creator><creator>Guan, Q Y</creator><creator>Heiman, J R</creator><creator>Kuffel, S W</creator><creator>Peterson, B T</creator><creator>Maravilla, K R</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Influence of PDE5 inhibitor on MRI measurement of clitoral volume response in women with FSAD: a feasibility study of a potential technique for evaluating drug response</title><author>Yang, C C ; Cao, Y Y ; Guan, Q Y ; Heiman, J R ; Kuffel, S W ; Peterson, B T ; Maravilla, K R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-99c5093b5607a58c72d2d49c1222549dba5b76b97ac8ce6645cc59756ee09ae83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Clitoris</topic><topic>Clitoris - drug effects</topic><topic>Clitoris - physiopathology</topic><topic>Diagnosis</topic><topic>Dosage and administration</topic><topic>Double-Blind Method</topic><topic>Drug therapy</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Genital diseases, Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical examination</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>original-article</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Piperazines - pharmacology</topic><topic>Purines - pharmacology</topic><topic>Reproductive Medicine</topic><topic>rology</topic><topic>Sexual Dysfunctions, Psychological - drug therapy</topic><topic>Sildenafil</topic><topic>Sildenafil Citrate</topic><topic>Sulfones - pharmacology</topic><topic>Urology</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, C C</creatorcontrib><creatorcontrib>Cao, Y Y</creatorcontrib><creatorcontrib>Guan, Q Y</creatorcontrib><creatorcontrib>Heiman, J R</creatorcontrib><creatorcontrib>Kuffel, S W</creatorcontrib><creatorcontrib>Peterson, B T</creatorcontrib><creatorcontrib>Maravilla, K R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of impotence research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, C C</au><au>Cao, Y Y</au><au>Guan, Q Y</au><au>Heiman, J R</au><au>Kuffel, S W</au><au>Peterson, B T</au><au>Maravilla, K R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of PDE5 inhibitor on MRI measurement of clitoral volume response in women with FSAD: a feasibility study of a potential technique for evaluating drug response</atitle><jtitle>International journal of impotence research</jtitle><stitle>Int J Impot Res</stitle><addtitle>Int J Impot Res</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>20</volume><issue>1</issue><spage>105</spage><epage>110</epage><pages>105-110</pages><issn>0955-9930</issn><eissn>1476-5489</eissn><abstract>The purpose of this study was to determine if magnetic resonance imaging (MRI) could quantify a difference in clitoral response following administration of a vasoactive medication, in 12 women with female sexual arousal disorder (FSAD). Subjects were entered into a double-blind, randomized two-way crossover study of sildenafil 50 mg vs placebo administered 1 h prior to genital MRI. Each subject underwent two MR studies, performed while subjects viewed alternating segments of nonerotic and erotic video. MR images were analyzed for change in clitoral volume during each session. The mean change in clitoral volume for the entire group was higher in the sildenafil MRI session (1282 mm
3
) compared with placebo (849 mm
3
) but did not reach statistical significance (
P
=0.064). Comparison using analysis of variance between the two sessions for each individual subject revealed a significant increase in clitoral volume following sildenafil compared with placebo in 6 of 12 subjects, no significant change in either imaging session in three subjects and in three subjects, there was a robust clitoral response in both MR sessions. In conclusion, MR measurements of clitoral volume can provide an objective measure of engorgement change following a vasoactive medication in women with FSAD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18059502</pmid><doi>10.1038/sj.ijir.3901625</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Biological and medical sciences Clitoris Clitoris - drug effects Clitoris - physiopathology Diagnosis Dosage and administration Double-Blind Method Drug therapy Feasibility Studies Female Genital diseases, Female Gynecology. Andrology. Obstetrics Health aspects Humans Magnetic Resonance Imaging Medical examination Medical sciences Medicine Medicine & Public Health original-article Phosphodiesterase Inhibitors - pharmacology Piperazines - pharmacology Purines - pharmacology Reproductive Medicine rology Sexual Dysfunctions, Psychological - drug therapy Sildenafil Sildenafil Citrate Sulfones - pharmacology Urology Vasodilator Agents - pharmacology |
title | Influence of PDE5 inhibitor on MRI measurement of clitoral volume response in women with FSAD: a feasibility study of a potential technique for evaluating drug response |
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