Synovial fluid macrophages are capable of osteoclast formation and resorption

To determine whether synovial fluid (SF) macrophages isolated from the SF of osteoarthritis (OA), rheumatoid arthritis (RA) and pyrophosphate arthropathy (PPA) joints are capable of osteoclast formation, and to investigate the cellular and humoral factors required for this to occur, SF macrophages (...

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Veröffentlicht in:	The Journal of pathology 2006-01, Vol.208 (1), p.35-43
Hauptverfasser:	Adamopoulos, IE, Sabokbar, A, Wordsworth, BP, Carr, A, Ferguson, DJ, Athanasou, NA
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - physiopathology Biological and medical sciences Bone Resorption - immunology Bone Resorption - physiopathology Carrier Proteins - immunology Carrier Proteins - physiology Cell Differentiation - immunology Cell Differentiation - physiology Cells, Cultured Chondrocalcinosis - immunology Chondrocalcinosis - physiopathology Diseases of the osteoarticular system Female Humans Interleukin-1 - immunology Interleukin-1 - physiology Investigative techniques, diagnostic techniques (general aspects) Knee Joint - immunology Knee Joint - physiopathology Lipopolysaccharide Receptors - immunology macrophages Macrophages - immunology Macrophages - physiology Male Medical sciences Membrane Glycoproteins - immunology Membrane Glycoproteins - physiology Middle Aged Osteoarthritis Osteoarthritis, Knee - immunology Osteoarthritis, Knee - physiopathology osteoclasts Osteoclasts - immunology Osteoclasts - physiology Osteogenesis - immunology Osteogenesis - physiology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phenotype pyrophosphate RANK Ligand Receptor Activator of Nuclear Factor-kappa B rheumatoid arthritis synovial fluid Synovial Fluid - immunology Synovial Fluid - physiology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - physiology
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